فهرست مطالب mohammad reza pishnamaz

Graft Versus Host Disease (GVHD) is an inflammatory immune disease, mediated by the donor’s immune cells and can arise after allogeneic Hematopoietic Stem Cell Transplantation (HSCT) for the treatment of hematologic malignancies. It can lead to destructive manifestations in various tissues, particularly dermatological, gastrointestinal, and ocular tissues. The most common ocular morbidity is dry eyes, which is often the first manifestation of GVHD. Regulatory T cells (Tr) can be broadly classified as natural or adaptive (induced). After Bone-Marrow Transplantation (BMT), excessively increased levels of type 1 Tr (Tr1) are generally observed with absence of a GVHD, while low levels are seen with severe GVHD. Treatment of patients, undergoing BMT with Interleukin-10 (IL-10)-anergized donor T cells, led to immune reconstitution without the development of GVHD, which resulted in protection against infection and against the return of the cancer. Surprisingly, in both naive syngeneic mouse models of skin and cardiac allografts, graft retention was augmented after infusion of in vitro generated double-negative Tr (DN Tr). In addition, GVHD was reduced in mice with a genetic deficiency in the IL-27 receptor (IL-27R-/-) and in mice treated with anti-IL-27p28–specific antibody. Considering above mentioned findings we would suggest carrying out experiments, using animal models of GVHD, in order to evaluate the potential role of Tr, as an innovative approach to overcome severe ocular morbidity caused by ocular GVHD.

Measurement of Visual Acuity (VA) has been used for eye examinations under various clinical conditions. In addition, because of changes in VA with a range of eye diseases, its measurement is used to screen, diagnose, and evaluate response to treatment in numerous eye diseases and predict the patient's visual function. VA and the likelihood of astigmatism could be evaluated simultaneously using a newly designed Stripped Circle (SC) VA chart. This chart has been developed based on the standard VA measurement scale chart, and the Landolt-C (LC) VA chart and all the standards for a VA chart design were implemented during its development. However, to publicize the clinical application of this VA measurement chart, further studies are required to evaluate its sensitivity, specificity, and repeatability compared with a similar standard VA chart.