جستجوی مقالات مرتبط با کلیدواژه « Solanum nigrum » در نشریات گروه « پزشکی »

Carbon tetrachloride (CCl4) is extensively used in various industries and induces oxidative stress in humans. Unfortunately, it is one of the neglected potent male reproductive toxicants.

The present research reports the testicular histopathology of CCl4 and ameliorations by four medicinal fruit pulp extracts (FPEs) in mice.

Sixty male albino mice were divided into six groups (10/group) as per the following: 1. Vehicle control (Vc); 2. CCl4 (C); 3-6. CCl4+Basella alba (CBa), CCl4+Solanum nigrum (CSn), CCl4+Ficus carica (CFc) and CCl4+Grewia asiatica (CGa). Except for the control group, CCl4 (0.1 mL of 0.2 mL kg-1) was given to the animals in corn oil. The four plant extracts (0.1 mL each) were respectively given to the relevant FPE group animals for the next five consecutive days, while the animals in the Vc and CCl4 groups received water instead of FPE.

The CCl4 exposure led to various histometric and histological alterations (loss of interstitial tissue and various dislodged tailless spermatids with enlarged heads) that were recovered in all except Solanum nigrum FPE mice post-treatment. The micrometric data of testicular sections also indicated significant decline in the number of spermatogonia, while the cross-sectional area of the sperm heads remained significantly higher in the CSn and C groups.

Except for Solanum nigrum, the three FPEs, especially Ficus carica, showed rehabilitative properties against CCl4 exposure-related modifications in testicular histopathologies.

Solanum nigrum (S. nigrum) is a species of flowering plant from the Solanaceae family and one of the indigenous plants of Eurasia. Given the biological activities of this plant, like antimicrobial, antioxidant, and anti-inflammatory ones, this study assessed its effects on the healing process of second-degree burn wounds in rats. We also evaluated its antibacterial activity against common pathogens of burn wound infection (i.e., Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter baumanni).

S. nigrum fruit extract was prepared by percolation and reflux methods. The extract was applied for the treatment of animal models with second-degree burn wounds. Parameters of wound healing and maturation, including collagen deposition, epithelialization, reduction of neutrophil migration, and angiogenesis, were evaluated. The antimicrobial activity of S. nigrum fruit extract against common pathogens of burn wound infection was assessed by the agar well diffusion method via measurement of zones of microbial growth inhibition.

Histological analysis showed a significant reduction in neutrophil migration by the 20% hydroalcoholic extract vs. control group (normal saline). In addition, we found that the 20% hydroalcoholic extract was more efficient than silver sulfadiazine in augmenting collagen deposition. S. nigrum hydro alcoholic extract also showed an inhibitory effect on S. aureus.

S. nigrum 20% hydroalcoholic extract improved some of the wound healing parameters such as collagen deposition and inflammation. It also shows an inhibitory effect on S. aureus. So, it may have therapeutic effects on burns.

Acinetobacter baumannii is a non-fermentative gram-negative bacterium that is common in nosocomial infections. As an opportunistic pathogen in hospitals, it is resistant to a large number of antibiotics and responsible for numerous infections such as bacteremia, pneumonia, meningitis, urogenital infections, and surgical wound infections.

We isolated 10 strains of Acinetobacter baumannii from urine samples of patients referring to Zabol Hospital. Solanum nigrumandSaponaria officinalis plants were harvested from Zabol city, dried in shade, milled, placed in a solvent solution (96% ethanol) for 24 h, and extracted using a rotary machine. The minimum inhibitory concentration (MIC) and the least bactericidal concentration were determined by the microdilution method.

The results of the antibiotic resistance testing showed that 100% of the strains were susceptible to antibiotics ceftazidime, gentamycin, and azithromycin while only 16.6% were resistant to ampicillin. The results of antimicrobial activity analysis showed that the leastminimuminhibitory concentration of Saponaria officinalis leaves extract was 25ppmagainst A. baumannii. Nine strains were inhibited at this concentration and one strain survived at all concentrations. The lowest minimum inhibitory concentration of Solanum nigrum extract was 12.5, with two strains being inhibited at this concentration and seven strains being inhibited at 25.

This study showed antimicrobial effects of Solanum nigrum and Saponaria officinalis extracts against A. baumannii. Therefore, they can be proposed as treatments for infections caused by this bacterium.

Solanum section Solanum has been extensively used in traditional medicine in Iran for many ailment treatments. The plant contains some substances such as total alkaloid, steroid alkaloid, steroidal saponins and glycoprotein, exhibiting anti-tumor activity.

In this research, wild species of Solanum section Solanum has been studied in Iran in the field of ethnobotanical investigation such as interviews, questionnaires, scientific articles, authentic books and ancient documents in traditional medicine. The anthropological uses of the plant have also been taken into consideration.

The wild species of these plants in Iran were studied using field and library methods. In the first method, to determine the distribution of Solanum and its related plants, numerous trips were carried out and many samples were collected. The anthropological use of these plants has been examined through interviews and questionnaires from 39 local people. In the second method, traditional Iranian books and published articles on the subject were also studied.  

According to this survey, these plants are commonly used for food digestion and constipation in traditional as well as current local medicine. In addition, we identified 180 different growing locations in Iran to illustrate their distribution maps.

These plants are being used as fever-reducing agent, pain-reliever, softener, laxative, diarrhea, anticoagulant and anti-asthma. Some outstanding results are obtained in the treatments of analgesic and sedative, anemia, burns, carminative, constipation, cough, cut restoration, food digestion, infections, mouth disinfection, skin diseases, toothache etc.

 The purpose of this study was to evaluate the antimicrobial effects of zinc oxide nanoparticale and extract of Solanum nigrum on Pseudomonas aeruginosa bacteria isolated from clinical specimens. Zinc oxide was purchased from the market. 20g of the dried and pounded leaves of S. nigrum was used and its extract was prepared in rotary device. 12 isolates of P. aeruginosa were isolated from referred patients to hospital Zabol. Finally, 12 isolates were used to growth inhibitory activity assay. Minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC) of Zinc oxide and extract plant against P.aeruginosa were evaluated using micro broth dilution method.The highest inhibitory concentration for P. aeruginosa is 1500 μg/ml, with four bacterial strains being inoculated. Also, the results showed that the highest drainage concentration was 3000 μg/ml, which two strains were inhibited in this concentration and the lowest trap concentration was 93 μg/ml. The lowest inhibitory concentration of extract plant was 0.62 mg / ml, with only one strain being inhibited in this concentration. The highest inhibitory concentration for P. aeruginosa is 40 mg / ml, with four bacterial strains being inoculated.The results showed that zinc oxide and extract of Solanum nigrum have a good antimicrobial activity on the bacterium and increases the concentration of antimicrobial activity.

The purpose of this study was to evaluate the antimicrobial effects of zinc oxide nanoparticale and extract of Solanum nigrum on Pseudomonas aeruginosa bacteria isolated from clinical specimens.
Zinc oxide was purchased from the market. 20g of the dried and pounded leaves of S. nigrum was used and its extract was prepared in rotary device. 12 isolates of P. aeruginosa were isolated from referred patients to hospital Zabol. Finally, 12 isolates were used to growth inhibitory activity assay. Minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC) of Zinc oxide and extract plant against P.aeruginosa were evaluated using micro broth dilution method.
The highest inhibitory concentration for P. aeruginosa is 1500 μg/ml, with four bacterial strains being inoculated. Also, the results showed that the highest drainage concentration was 3000 μg/ml, which two strains were inhibited in this concentration and the lowest trap concentration was 93 μg/ml. The lowest inhibitory concentration of extract plant was 0.62 mg / ml, with only one strain being inhibited in this concentration. The highest inhibitory concentration for P. aeruginosa is 40 mg / ml, with four bacterial strains being inoculated.
The results showed that zinc oxide and extract of Solanum nigrum have a good antimicrobial activity on the bacterium and increases the concentration of antimicrobial activity.

Nowadays, plants have been considered as powerful agents for treatment of disorders regarding to their traditional use. In Iranian Traditional Medicine (ITM), plants have a special role in the treatment of various diseases. Burns with their devastating outcomes have been discussed in ITM as well. In the present study, a polyherbal ointment (PHO), retrieved from ITM, was formulated for burn healing and it’s HPTLC fingerprint was prepared. Aqueous extracts of Malva sylvestris and Solanum nigrum leaves and oily extract of Rosa damascena petals (4.85%, 4.85% and 33%, respectively) were added to white beeswax, eucerin and white petrolatum as ointment base. In addition to the microbiological tests, physical stability and rheological behavior of the product were assessed. Fingerprinting of phytochemical constituents of PHO was performed by using silica gel plates and toluene: ethyl acetate: acetic acid (60: 40: 1) and ethyl acetate: formic acid: acetic acid: water (100: 11: 11: 10) as mobile phases. The results showed that PHO was stable towards physical changes and successfully passed microbiological tests. Moreover, PHO exhibited plastic behavior which is in favor of a topical burn product. In addition, HPTLC fingerprinting of PHO demonstrated the presence of several phenolic constituents corresponding to the plant extracts. Regarding to the role of phenolic compounds in wound healing process, PHO could be an appropriate candidate for burn healing with respect to its traditional use in ITM. Moreover, HPTLC fingerprinting could be utilized as an applicable method for quality control of the prepared formulation.

Burns are known as one of the most common and destructive forms of injury with a vast spectrum of consequences. Despite the discovery of various antibacterial and antiseptic agents, burn wound healing still has remained a challenge to modern medicine. Plants, with a valuable traditional support, have been considered as potential agents for prevention and treatment of disorders in recent years. However, modern scientific methods should be applied to validate the claims about the therapeutic effects of the herbal products.. This study was conducted to evaluate the wound-healing activity of a poly herbal cream (PHC), retrieved from Iranian Traditional Medicine (ITM), in a rat burn wound model in Iran.. In this experimental study, PHC containing aqueous extracts of Malva sylvestris and Solanum nigrum leaves and oily extract of Rosa damascena petals was used. Second-degree burn wounds were induced in four groups of five rats each. Group 1 received no treatment while groups 2, 3 and 4 were given cream base, silver sulfadiazine (SS) 1% and PHC, respectively to compare the efficacy of PHC with the negative and positive control groups. The percentage of wound healing on days 2, 6, 10 and 14 and histopathological parameters of healed wounds on the 14th day were assessed. Antioxidant and antimicrobial activities of PHC were evaluated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and micro-dilution methods, respectively.. There was a significant improvement in healing percentage of PHC-treated rats in comparison to the other groups at the end of the treatment period (87.0% ± 2.1% for PHC in comparison to 32.2% ± 1.6%, 57.0% ± 5.3% and 70.8% ± 3.5% for the control, cream base and SS groups, respectively). Moreover, the healed wounds in PHC-treated animals contained less inflammatory cells and had desirable re-epithelialization with remarkable neovascularization. In addition to the antioxidant activity, PHC exhibited antibacterial effect against Staphylococcus aureus.. Poly herbal cream experimentally and histopathologically revealed a burn wound healing activity probably due to the antioxidant, anti-inflammatory and antimicrobial activities of its phytochemical contents. Therefore, this study confirms the use of M. sylvestris, S. nigrum and R. damascena in burn prescriptions in ITM..

The methanolic extract of whole plants of Solanum nigrum L. was investigated for anti-inflammatory activity on the experimental animal models. The methanolic extract at a concentration of 100 mg.kg-1 and 200 mg.kg-1, p.o. showed the significant dose dependent anti-inflammatory activity in carrageenin and egg white induced hind paw oedema in rats. Anti-inflammatory activity of the tested extract was comparable with that of the standard drug indomethacin (10 mg.kg-1) and cyproheptadine (8 mg.kg-1). The results lend support to the traditional use of Solanum nigrum in the treatment of inflammatory diseases.