فهرست مطالب
ماهنامه برزگر
پیاپی 1039 (نیمه اول خرداد 1389)
- 50 صفحه، بهای روی جلد: 30,000ريال
- تاریخ انتشار: 1389/04/15
- تعداد عناوین: 19
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صفحه 4
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صفحه 6Introduction: Hyperthyroidism is a relatively common disorder caused by different etiologies. Graves’ disease, and toxic-nodular goiter (Plummer’s disease) are among the most common causes. Treatment with radioiodine is considered to be the treatment of choice in many of the patients. Higher biological half-life of 131I in hyperthyroid patients as compared with patients with differentiated thyroid carcinoma who have undergone thyroidectomy, may lead to a higher frequency of complications with radioiodine at similar dosage. Therefore gonadal dysfunction in hyperthyroid patients treated with radioactive iodine is not unlikely. Material and Methods: Hyperthyroid patients with the clinical diagnosis of Graves’ disease, toxic multinodular goiter and toxic adenoma were entered the study. Their age distribution was 16-40 years in women and 17-60 years in men (Reproductive years). Patients were euthyroid at the time of radioiodine treatment. FSH, LH, testosterone and semen analysis in men; and FSH, LH, estrogen and progesterone in women were measured before and 3 months after radioiodine therapy. All patients with previous history of radioiodine treatment, those with known sexual hormone abnormalities, women with a history of tube ligation and men with a history of vasectomy, as well as those women who were receiving OCP contraception were excluded from the study. Results: From 104 enrolled patients, 40 (38.5%) were men and 64 (61.5%) were women. The cause of hyperthyroidism was Graves’ disease in 66 cases (63.5%), toxic multinodular goiter in 28 cases (26.9%) and toxic adenoma in 10 others (9.6%). Hormonal status was normal in all patients before therapy while this became abnormal in 20 (19.2%) of patients after treatment. Semen analysis became abnormal in 8/20 (40%) of the patients after treatment. Conclusion: Among different variables which were analyzed during study, meaningful correlation was found in the following situations: FSH values in men and women were found to be increased after radioiodine treatment (P<0.0001), sperm count decreased from 124000000 to 62000000 (P<0.0001), the difference in semen analysis changes was also meaningful in men among two different age groups (=<35, >35) (P=0.003) and changes in hormonal status in women in two different age groups (=<30, >30) were found to be statistically significant (P=0.015).
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صفحه 9Scientimammography (SMM) is a new non-invasive method of imaging breast tumors which in various studies the overall sensitivity of 83%-95.8% and specificity of 52%-95% is reported. The purpose of our study was to evaluate the usefullness of 99mTc-MIBI SMM in our environment in detecting breast cancer and in reducing the rate of biopsy. 65 patients aged 23-70 years were included in this study. The overall sensitivity and specificity of SMM were 84.6% and 71.8% respectively. The PPV of 66.6% and NPV of 87.5% were similar to that obtained by others. These results showed that, SMM did not increase the specificity and PPV of mammography. However SMM is a useful method for evaluating patients with low suspicion or indeterminate mammographic or palpable findings or lesions larger than 1.5 cm.
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صفحه 12Radionuclide shuntography is a safe and simple method to determine shunt patency and analyze changes in CSF (Cerebro-Spinal-Fluid) flow. We present a case of complicated CSF shunt, in which radioisotopic scan correctly identified disconnection of the shunt tubing system localizing the site of extravasation accurately. The findings were confirmed by surgery performed for correction of the shunt system.
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صفحه 16Human nonspecific polyclonal IgG was labeled with125I through direct and indirect labeling methods using chloramine-T and a non-Phenolic radioiodinated intermediate N-Succinimidyl-4-[125I] iodobenzoate (125I-SIB), respectively. Tissue distribution of radioiodinated IgG was assessed in normal and induced inflammation mice. Although, radioiodinated IgG accumulated in the inflammatory area, results showed decreased thyroid and stomach activity and improved inflammatory thigh-to-normal tissue ratios with the indirect labeling method (125I-IB-IgG) compared with direct labeling method (125I-IgG), indicating reduced in vivo deiodination. These results indicate that the 125I-SIB is probably a preferable approach for labeling antibodies with iodine radioisotopes.
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صفحه 21Although, most of the abnormal structures of human brain do not alter the shape of outer envelope of brain (surface), some abnormalities can deform the surface extensively. However, this may be a major problem in a surface-based registration technique, since two nearly identical surfaces are required for surface fitting process. A type of verification known as the circularity check for the shape of the detected head contours was defined based on the curvature measurement. Any unacceptable deformity (or hole) existing in the brain surface can be detected by the circularity check and ''reformed'' by a type of interpolation process. Two techniques were suggested to ''reform'' the abnormal regions and holes on the surfaces: one based on median filtering and another based on contour reflection.
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صفحه 36
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نیازمندی های برزگرصفحه 50