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فصلنامه گوارش
Govaresh
ISSN 2008-756x
فصلنامه پزشكي، پيراپزشكي داراي رتبه علمي - پژوهشي (پزشکي) به زبان فارسي - انگليسي
سال بيست و يكم، شماره 4 (پياپي 97)، زمستان 1395
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 | Endoscopic Findings in Patients with Upper Gastrointestinal Bleeding Referred to Taleghani Hospital, Tehran, Iran
Afsaneh Sharifian , Esmaeil Tavakoli , Sara Ashtari * , Mohammad Reza Zali Page 193
 Abstract  Full Text [PDF 632KB] | | Background: Upper gastrointestinal bleeding (UGIB) remains a common medical problem worldwide. It is an emergency medical condition، which may require hospital admission. UGIB also increases the risk of morbidity، and mortality and uses health care resources. The aim of this study was to determine the endoscopic findings and their frequencies in patients with UGIB with regard to age in Tehran’s Taleghani Hospital.
Materials and Methods: The medical records and endoscopy reports of 990 patients، who underwent endoscopy for UGIB in Tehran’s Taleghani Hospital over a period of 2 years from 2010 to 2012، were retrospectively analyzed.
Results: A total of 990 patients consisted of 594 (60%) men and 396 (40%) women had endoscopy for UGIB. Mean (±SD) age of the patients was 54 (±17.2) years. The commonest (45.5%) cause of UGIB was peptic ulcer disease، which included; duodenal ulcer (26.4%)، gastric ulcer (19.1%)، followed by esophageal and gastric varices (19.5%). Malignant conditions (cancers) contributed to 14.7%، which included gastric cancer (7.2%)، esophageal cancer (5.5%)، and duodenal cancer (2%). Other less frequent causes of UGIB were esophageal ulcer (6.7%)، erosive gastritis (6.3%)، Mallory-Weiss syndrome (5.4%)، and Dieulafoy’s lesion (1.2%). Normal endoscopic findings were recorded in 0.7% of the patients with UGIB.
Conclusion:Peptic ulcer diseases are the commonest cause of UGIB followed by esophageal and gastric varices.
Keywords: Upper gastrointestinal bleeding, Endoscopy, Iran
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| Pitfalls in Estimation of Celiac Disease Prevalence Using Serology: A Cross-Sectional Study
Mohammad Taghi Shakeri , Azita Ganji * , Majid Ghayuor Mobarhan , Vahid Ghavami Ghanbarabadi , Leili Rahimi Page 194
Abstract Full Text [PDF 661KB] | | Background: Celiac disease (CD) is an auto-immune disorder. The prevalence of CD has been estimated mainly based on serological tests. The aim of this study was to evaluate the seroprevalence of celiac disease in the adult general population of Mashhad، northeast of Iran and pitfall of serology in epidemiological studies considering the importance of serology titer.
Materials and Methods: 1558 subjects aged 35 to 65 years and 1025 individuals aged between 15 to 35 years were selected randomly from multistage cluster sampling papulation for this cross sectional study. Anti-tissue transglutaminase (tTG)-IgA assay was performed by ELISA(Enzyme-Linked Immunosorbent Assay). The manufacture’s cut-off point of anti tTG was 20 IU/mL and the prevalence of positive serology was estimated based on being just above the upper limit of normal (20 IU/mL)، twice or three times above the normal value at 40 and 60 IU/mL، respectively.
Results: In both age group 35-65 year-old and 15 to 35 years adults، the prevalence of positive serology was 1.2% for anti-tTG level more than 60 IU/mL، which was three times of the kit references (95% CI: 0.7- 1.9) and (95% CI: 0.7-2.1)، and based on our previous study in Mashhad if we consider the cut-off point as 76 IU/mL anti–tTG for mucosal atrophy، the prevalence of CD would be 0.69.
Conclusion: Epidemiological data of CD is mainly based on serology and as these tests are to some extent non-specific at lower levels، the accuracy of the previous reported prevalence of CD in some studies are questionable and level of anti-tTG is important.
Keywords: Celiac disease, Tissue transglutaminase, Prevalence, Serology
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| ژنتيك و رويكرد آن در تشخيص بيماريهاي با سابقه فاميلي
اشرف محمدخاني* ص 220
چکيده مشاهده متن [PDF 366KB] | | بطور كلي هر دو شكل بيماري هاي رايج و بيماري هاي نادر مي توانند در افراد خانواده ها بروز نمايند، بنابراين، جمع آوري سابقه خانوادگي مي تواند يك ابزار غربالگري قدرتمند براي شناسايي اين بيماري ها بشمار رود كه بايد درهربارمراجعه افراد به روزشده و افراد بيماربايد ازاهميت آن درحفظ سلامت خود و بستگان آگاه شوند. براي آگاهي بيشتر در مشخص نمودن الگوي وراثتي بيماري ها، دراين مقاله درابتدا شواهد موجود درشباهت ژنتيكي درون و بين جمعيت هاي انساني و تنوع ژنتيكي بشر را به اختصار توضيح خواهيم داد و سپس به اهميت انجام مشاوره پزشكي و رسم شجره نامه و لزوم جمع آوري نمونه هاي بيولوژي براي انجام مطالعات ژنتيكي خواهيم پرداخت.
کليدواژگان: ژنتيك، وراثت، سابقه خانوادگي، شجره نامه، مشاوره ژنتيك
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| بررسي ارتباط انواع منابع چربي رژيم غذايي با خطر ابتلا به سرطان پانگراس در قالب مطالعه كوهورت استان گلستان
زينب قرباني، آزيتا حكمت دوست، حسين پوستچي، اكرم پورشمس، اكبر فاضل تبار ملكشاه، مريم شرفخواه، رضا ملك زاده* ص 229
مشاهده متن [PDF 364KB] | | |
| بررسي شيوع هليكو باكتر پيلوري و متاپلازي روده اي در بيماران مشكوك به گاستريت در يك بازه زماني هفت ساله
سارا اشتري، محمدامين پورحسينقلي*، مهسا مولايي، محمدرضا زالي ص 237
مشاهده متن [PDF 344KB] | | |
| گزارش يك مورد پارگي مري در اثر بلع جسم شيشه اي
احمد حرمتي*، محمدرضا قدير، سيدسعيد سركشيكيان، ابوالفضل ايراني خواه، سجاد رضوان ص 238
مشاهده متن [PDF 365KB] | | |
| ترجمه و بررسي روايي و پايايي پرسشنامه مقياس سوء هاضمه نپين در بيماران سوء هاضمه عملكردي در ايران
محمدرضا شيخيان، سهيلا ميسمي بناب*، شقايق عشقي، ليدا جراحي ص 243
مشاهده متن [PDF 705KB] | | |
تاريخ انتشار: 4/12/95
تلفن: 88335061 (021)
تاريخ درج در سايت: 4/12/95
شمار بازديدکنندگان اين شماره: 193
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