نشریه ارمغان دانش
سال بیست و سوم شماره 2 (پیاپی 127، خرداد و تیر 1397)

Tissue engineering is a new method for replacing tissue fragments degraded by biodegradable polymers, which is provided as a three-dimensional scaffold for the growth and propagation of stem cells. In this study, chitosan was used to evaluate the migration and proliferation of fibroblasts in the presence of hyaluronic acid.
Material and In this study, scaffold chitosan was prepared for the growth of fibroblastic cells. Then, for further studies, scaffolds were divided into the following groups: Group 1: Chitosan scaffold with hyaluronic acid
Group 2: Chitosan without hyaluronic acid scaffold
Group 3 (control 1): Hyaluronic acid fibroblast cell
Control group 2: Hyaluronic acid-free fibroblastic cell
The human foreskin was prepared and the fibroblast cells in the dermal layer were centrifuged after separation, and the cells were transferred to the culture flasks with DMEM medium and stored in a CO2-encoded incubator. After several passage cells, 10,000 cells were transferred to 96 wells containing DMEM medium and MTT and DAPI staining were investigated and the fibroblasts were infiltrated on the chitosan scaffold. The obtained results were analyzed by SPSS software, ANOVA and post hoc Tukey test.
The results showed that the mean survival rate of chitosan without hyaluronic acid scaffold in 24 hours was significantly higher than hyaluronic acid and chitosan groups with hyaluronic acid (P The results of this study showed that chitosan scaffolds with regard to hydrophilicity, better biocompatibility with fibroblast cells, suggest that chitosan may be synthesized in structures that are synthesized to repair affected areas of skin. Have a proper and complementary role.

Gentamicin is an aminoglycoside antibiotic used to treat a variety of bacterial infections particularly Gram-negative ones. However, the nephrotoxicity and oxidative damage caused by gentamicin limit its long-term clinical use. Grean tea contains some phenol compounds called catechins which have antioxidant and anti-inflammatory effects. AQP1 is a protein that make a water channel in renal tubules that transported water during the appical and baso-lateral of the renal tubuls. To cheching the protective effect of Grean tea extract(GTE) in AQP1 gene expression in Gentamicin treated rat kidney, this search has prepared.
In this experimental study,30 Wistar male rats 6-4 weeks 160 - 200g were used and divided into 5 groups (n=6) to receive saline; gentamicin 20 mg/kg ; GTE 200 mg/kg/B.W. ; GM GTE 200 mg/kg/B.W. ;intraperitoneal for 10 days and control group. Biochemical changes in blood urea and creatinine levels evaluated Based on the reaction of Bertolt and Chlorometric and Gaffa method and renal changes were evaluated by means of histochemistry and immunohistochemistry. The Data was analyzed with using of one-way ANOVA, followed by Tukey's HSD tests using SPSS 21.
The mean of Levels of creatinine and blood urea increased significantly in the First group compared to the control group (P From the findings of this study, it can be concluded that green tea extract in this dose and duration can not have a protective effect against the renal toxicity of gentamicin

introdution: The aim of this study was investigating the effect of different endurance training intensity on the expression of FSP27 protein in visceral adipose tissue and insulin resistance in male diabetic Wistar rats.
40 male Wistar rats were divided into five groups of eight, including diabetic group and low intensity endurance training (DLE), diabetic group and moderate intensity endurance training (DME), diabetic group and high intensity endurance training (DHE), diabetic control group (DC) and healthy control group (HC). After diabetic injection with streptozotocin, an endurance training (low, moderate, and high) was performed for eight weeks, three sessions per week and each session for 30 minutes. serum levels of insulin , glucose and insulin resistance index and also the relative expression of FSP27 protein was measured. One-way ANOVA and Tukey and Games-Howell post hoc tests were used to determine the difference between groups.
The results indicated a significant effect of Endurance training with three intensities (low, medium and high) on serum levels of insulin and glucose and insulin resistance values (p = 0.001). Reduction serum levels of insulin and glucose in high intensity training group and moderate intensity training group compared to diabetic control group and low intensity training group were significant (P≤0.05). Insulin resistance values were significant between moderate and high intensity training groups compared to low intensity training group, diabetic control group, and healthy control group (P≤0.05). FSP27 expression was not significantly different in endurance training groups with three intensities compared with diabetic control and healthy control groups.
Although in this study, none of the endurance training interventions made a significant difference in FSP27. Considering the desire to increase the FSP27 with increasing intensity endurance training, It seems that endurance training with an appropriate intensity can be increase insulin sensitivity and improve insulin resistance in diabetic rats.

Marital adjustment is one of the most important factors affecting family performance. According to Communicational approaches having and teaching of communication skills, play a great role in enhancing marital adjustment and decreasing of intimate relationships problems. The purpose of this study was to investigate the effect of the practical application of intimacy relationship skills (PAIRS) on the marital adjustment.
The research method was semi-experimental and its design was a pretest-posttest with the control group. The statistical population consisted of women who were referred to intervention the center of individual, familial and sociological crises of the Bojnord city in 2017 due to maladjustment and marital conflicts The sample consisted of 26 volunteers who were selected using available sampling method and randomly assigned to two experimental and control groups (each group of 13). Information gathering instrument was Spanier dyadic questionnaire that completed by each two group in before and after the intervention. Experiment group participated in eight two-hour sessions of PAIRS and the control group no received the intervention. Multivariate analysis of covariance (MANCOVA) and Analysis of covariance (ANCOVA) was used to analyze the data. Data analysis was performed using the SPSS-24 software.
Research findings show PAIRS is effective in enhancing the marital adjustment (F=108.72) and dimensions of satisfaction (F=35.84), cohesion (F=80.60), consensus (F=36.48) and affection expression (F=12.35), (p PAIRS improves the marital adjustment. Accordingly, suggested that take advantage of PAIRS to improving the marital relationships and enhancing their marital adjustment.

Ginger has antioxidant properties that improve oxidative indices. The use of high-fat diet is one of the reasons for the prevalence of liver disease. Therefore, the aim of the present study was to investigate the effect of ginger and treadmill walking on serum levels of hepatic enzymes and tissue changes induced by high-fat diet in mature male rats.
In this experimental study, 56 mature male rats were divided into control (without treatment), control (treatment with high-fat diet 10 ml/kg) and 5 experimental groups receiving high-fat diet (10 ml/kg) with 200 and 100 mg/kg ginger extract alone and with treadmill walking. Ginger was administered as gavage in 28 consecutive days. At the end, after anesthetizing the animals and collecting blood from their hearts the AST, ALT and ALP enzymes were measured, and their liver was removed and after preparing the tissue sections, the results of hepatic enzymes measurements were analyzed by ANOVA and Duncan tests and P≤0.05 was considered significant.
The results showed that high-fat diet increased AST, ALT and ALP enzymes and tissue damage of the liver compared to the control group at the level of p The results showed that high-fat diet increased the levels of ALT, AST and ALP, and hepatic tissue damage. Treadmill walking and ginger extract alone and together reduce ALT, AST and ALP and improve the hepatic tissue structure.

Regarding that, the disturbance in testicular blood circulation and consequently testis ischemia can disrupt fertility. In this study, the protective effect of bone marrow mesenchymal cells on the testicular histomorphometry following spermatic cord Torsion-Detorsion was investigated comparatively
In this experimental study, 30 adult mice were randomly divided into three groups. In Con-sham group, the laparotomy has been done without the torsion-detorsion (T-D). T-D group, in this group torsion-detorsion was created in the left testicular cord and after repefusion, 10µl PBS injected into the rete testis. In (T-D㋇) group, after left testicular cord torsion-detorsion mesenchymal cells (5×105 in 10µL) was injected into rete-testis. At the end of the treatment period, (35 days) the left testis were fixed and paraffin sections stained with H&E and Masson-trichrom for the number of blood vessels. The different histomorphometric parameters were calculated. Obtained data were analyzed by SPSS software and ANOVA statistic method and Tukey post hoc test.( P This study showed that the different histomorphometric parameters such as spermatogenesis indices, mean number of active Sertoli and Lydig cells, seminiferous tubules diameter, thickness of germinal epithelium and testicular capsule, in the treatment group (T-D㋇), significantly increased in comparison to the T-D group (P Histomorphometrical studies have shown that the use of mesenchymal cells in the process of improvement of the impact due to testicular cord torsion-detorsion can be effective by increasing angiogenesis and tissue repairing.

The Effect of a Course of Exercise Training in Water on Glycated Hemoglobin and C-Reactive Protein in Type2 Diabetic Women.
Mohammadi A*1, Khajehlandi A1, Derakhshan K2
1: Department of Physical Education, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran.2- Student of Physical Education.( Exercise Physiology)
Abstract: Diabetes has been known as the most common metabolic- endocrine disorder, which causes unpleasant effects of the eye, kidney, nervous and heart. Thus the purpose of this study was to examine the effect of water exercise training on Glycated hemoglobin and C-reactive protein in type 2 diabetic women.
This is a semi-experimental study so 30 women with type 2 diabetes were selected purposefully and randomly assigned to either control (n = 15) or experimental (n = 15) groups. The exercise protocol was performed for 8 weeks, each week for 3 sessions and 60-70 minutes for each session in the indoor swimming pool. No intervention was conducted on the control group during this study. Independent t-test and paired t-test were used to evaluate changes in variables.For statistical analysis using SPSS-21 software at a significant level of P The results showed that body mass index (P it seems that 8 weeks of water exercise training can prevent type 2 diabetic women by decreasing changes in anthropometric indices, CRP levels, Glycated Hemoglobin and Insulin Resistance (HOMA-IR).

Substance abuse has led to a reduction in productivity and inefficiency in psychological issues, including psychological well-being among drug users. The aim of this study is to evaluate the effectiveness of group Cognitive Hypnotherapy on psychological well-being of residential and semi-residential addiction treatment centers in the city of Yasuj.
This study was quasi-experimental with pretest and post-test and control group. Number 40 patients were selected and sampling method was experimental and control groups. The instrument used in this research were the Ryff Psychological well-being intervention group Cognitive Hypnotherapy was conducted on the experimental group, But no intervention control group received nothing. Cognitive Hypnotherapy intervention model was carried out on the experimental group for 8 sessions for one hour once a week, but there was no intervention on control group. After the end of the intervention, both groups test was taken. In order to analyze the data collected from of the was used analysis covariance.
Results showed that group Cognitive Hypnotherapy, psychological well-being leads to an increase in the experimental group compared with the control group at the significant level (p Group cognitive hypnotherapy can play-based an important role psychological well-being in promoting Take over Substance Abuse Patients.

Brucellosis is a serious problem in many regions of the world including Iran. The aim of this study is to investigate the epidemiologiclal Features of reported cases in Children and Teens with brucellosis in Kohgilouyeh and Boyerahmad.

Material & This cross-sectional (descriptive-analytic) study consisted of all Children and Teens 1 to 18 years diagnosed with Brucellosis between 2009 and 2015, whose information was available in the health centers of Kohgilouyeh and Boyerahmad province.Data analysis was performed using SPSS software (version 19) after data entry.
The total number of people infected with brucellosis was 81 patients, of whom 40 patients (49.4%) were male and (50.6%) were female others. A total of 67 patients (82.7%) were residents of the rural and tribal areas, and the 14 others(17.3%) lived in the urban areas. The mean age of the patients was 11.30 ± 4.73 years and the most prevalent age groups were 11-18 years old With 61.7%. The disease was more common among students (48.1%) and in the first six months of the year it was more common (79 %). The most common way of transmission is through suspected dairy products and close contact with infected livestock with (85.2%) and (81.5%) respectively. Approximately, 82.8% of all patients had a diagnosis to treatment time between 0 and 3 months (acute brucellosis) and about 17.2% between three months to one year (subacute brucellosis). The most commonly observed clinical symptoms included pain, specifically bone pain (74.1%), fever (58%), low back pain (55.6%), weakness and anorexia (42), weight loss (32.1%), weakness and lethargy (2.5%),and depression (1.2%). There was a significant difference between incidence Brucellosis and history of vaccination of livestock(p Due to the prevalence of the disease in children and students in the nomadic areas, the timely control and detection of this groups who are among the active groups of society is essential. Further livestock vaccination, training this community and physicians can be helpful.

The schema therapy model emphasis’s on early maladaptive schemas in psychological disorder. This study aimed to determine effectiveness of Schema Therapy on severity of depression and Suicide ideation in patient whit treatment resistance depression.
This research was a semi experimental study using pre-test and post-test with control group. among all patients with treatment resistance depression visited in Naft and Sadooghi hospital of Tehran, 30 patients were selected through inclusion-exclusion criteria and availability sampling method then randomly were assigned into two equal experimental (15 persons) and control (15 persons) groups. Experimental group experienced 12 weeks of schema therapy, while control group were just followed. Beck depression inventory (BDI-II) and Beck suicide scale ideation (BSSI) were used in pre-test and post-test as the. Data were analyzed by Mancova via SPSS19 software.
The results of this research showed that the means of depression and suicide ideation in experimental group were reduced significantly in comparison with control group in post-test (P The study findings proposed that schema therapy can be used as an effective intervention in order to reduce of depression and suicide ideation in people with treatment resistance depression. It is recommended that psychologist and psychiatrist across the country use the schema therapy to reduce psychological problems of treatment resistance depression patients.