فهرست مطالب

Iranian Journal Of Dermatology
Volume:3 Issue: 2, 2000

  • 64 صفحه، بهای روی جلد: 5,000ريال
  • تاریخ انتشار: 1378/10/20
  • تعداد عناوین: 12
|
|
  • M Eslami Danesh Pajooh, F Jafari, M Farivar Sadri, M Valikhani Page 10
    Background

    Oral ivermectin is recently introduced for the treatment of scabies.

    Objective

    The objective of this clinical trial was to compare the efficacy and safety of oral ivermectin and topical Gamma Benzene Hexachloride (GBH) 1% for the treatment of scabies. Patients and

    Methods

    Fifty-eight cases were randomly assigned in the two treatment groups. In the ivermectin group, patients received a single oral dose of the drug (200 µg/kg). In the case of any signs of active disease, a second dose was administered one week later. All the patients in the GBH group received two topical applications of the drug, one week apart. The patients were seen after 48 hours, 1, 2, and 4 weeks.

    Results

    Of the 37 patients treated with ivermectin, 27 (73%) showed clinical cure with a single dose and 10 (27%) required a second dose one week later. In the 21 patients treated with GBH, 18 (85.7%) received two applications of GBH, and three cases (14.3%) were cured by an additional curse of precipitated sulfur 6%. No serious side effects were seen in either group. The mean time for the drop of pruritus, the sense of well being and the healing of lesions, were each shorter with ivermectin than GBH, and the differences were statistically significant.

    Conclusion

    Although all of the patients treated with ivermectin or topical GBH were cured, ivermectin cured faster than topical treatment.

    Keywords: Scabies, Ivermectin, Gamma benzene hexachloride
  • N Darvishi Zadeh Page 16
    Background

    Non-melanocytic skin cancers (NMSC) including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are mostly induced by long life sun ultraviolet radiation (UVR). Although many etiological factors are known in skin cancer, the role of sunlight is the most prominent. Khuzestan is one of the southern provinces of Iran, which has sunny sky and long summer. So it is presumed that skin cancers are common in Khuzestan.

    Objective

    To study non-melanocytic skin cancers in Ahwaz. Patients and

    Methods

    In this retrospective study, pathological diagnosis of NMSC in an educational hospital of the province has been analyzed.

    Results

    During years 1994-1998, total of 636 patients have been diagnosed, 40% female and 60% male. 83% of female patients had BCC and 17% had SCC. 71.5% of male patients had BCC and 26.5% had SCC. BCC to SCC ratio in male and female patients were 2.7 and 5 respectively, and 3.4 in whole. In both sexes the most common age of the diagnosis was the seventh decade. Most of the patients had outdoor occupations.

    Conclusion

    The results of this study indicate that NMSC is more common in male who have outdoor occupations and proper education and protective measures for individuals at high risk must be considered.

    Keywords: Non melanocytic skin cancer, Ultraviolet Radiation, Khuzestan
  • M Bayat Page 23
    Introduction

    Positive effects of topical application of honey on open skin wounds have been observed, Mast cell are playing role in normal wound healing and its disturbances but the role of mast cells in wound healing in existence of honey is uncertain.

    Objective

    The aim of this investigation was to study the effects of two times per day topical application of honey on the number of mast cells in skin wounds.

    Materials and Methods

    33 male rats were randomly divided into experimental and control groups. Under general anesthesia and sterile conditions, one round full thickness skin wound was made on the dorsum of neck of each rat. The diameter of wounds was about 3cm. Unboiled honey was applied topically on wounds twice per day from surgery day until certain days. On the fourth, seventh, and fourteenth days after surgery according to inflammation, proliferation and remodeling phases of wound healing process, samples were obtained from wound tissue and adjacent skin after rats were killed with ether. Samples were prepared for routine histological study and stained with 1% aqueous toluidine blue. Mast cells of wounds were counted and analyzed by Mann Whitney U test.

    Results

    The mean of mast cells was lower in experimental group in three above-mentioned days. The differences were statistically significant on days 4 and 7 (P<0.05 for fourth day, P<0.01 for seventh day, and P>0.05 for fourteenth day).

    Conclusion

    Twice per day application of honey on open full thickness skin wounds could reduce the number of mast cells significantly, in inflammatory and proliferative phases of wound healing.

    Keywords: wound healing, honey, mast cell
  • S Shamsoddini* Page 27

    Here are our meditation on the art of attracting, keeping, and helping patients. It contains some sections including “Be professional”, “Be reassuring”, “Be confident”, “Be informative”, “Be smart” and “Be responsive”.

    Keywords: Patient, History taking, Physical exam, Skin lesions
  • MA Mapar Page 35

    Cheilitis granulomatosa is a rare disorder of unknown etiology. The condition produces chronic and persistent swelling of one or both lips. The treatment of cheilitis granulomatosa is usually ineffective. Various forms of treatment have been used with variable success. Here I report a 40-year old woman from suburbs of Ahwaz, with persistent swelling of lower lip from 8 months ago, who had not responded to several therapies. She was treated with oral chloroquin 150 mg 3 times a day and topical ointment of Zinc oxide. The swelling of her lip subsided completely after 4 weeks of treatment. In follow up at 6 months, the disease was still in remission.

    Keywords: Cheilitis granulomatosa, Chloroquin, treatment
  • A Kiani, F Iraji, F Shariati Page 39

    Cutaneous leishmaniasis may present as unusual manifestations in renal transplant patients receiving immunosuppressive therapy. This misleading presentation, may delay the diagnosis and treatment. Moreover special caution must be taken in renal transplant recipients because of possible interactions between antimony compounds and cyclosporine metabolites. We report a 45-year old man with 5 years history of kidney transplantation receiving immunosuppressive drugs who had an extensive, painful ulcer on the left and upper side of his chest. Laboratory evaluation confirmed the diagnosis of cutaneous leishmaniasis. The patient was treated successfully with a 3-week period of intramuscular Glucantime.

    Keywords: Cutaneous leishmaniasis, Kidney transplant recipient, Immunosuppression