فهرست مطالب

Iranian Journal Of Dermatology
Volume:7 Issue: 4, 2004

  • تاریخ انتشار: 1383/02/15
  • تعداد عناوین: 10
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  • Firooz Ar, Khatami Ar, Khamesipour A., Nassiri Kashani M., Nilforoushzadeh Ma, Behnia F., Pazoki Toroudi Hr, Dowlati Y Page 209
    Background
    Several treatment modalities have been used for cutaneous leishmaniasis (CL) with various results. In vitro and in vivo studies have shown inhibitory effects of zinc sulfate (ZnSO4) on Leishmania parasites.
    Objective
    To compare the efficacy of intralesional injections of 2% ZnSO4 solution with meglumine antimonate (Glucantime) in the treatment of acute Old World CL. Patients and
    Methods
    Seventy-two patients with CL with a duration of less than 8 weeks were recruited in a randomized, double-blind, clinical trial in Isfahan province – an area endemic for Leishmania major – after giving written informed consent. They were treated with 6 weekly intralesional injections of either 2% sterile ZnSO4 solution or Glucantime prepared in identical vials. The primary outcome measure was complete re-epithelialization of CL lesions.
    Results
    Among 36 patients with 53 lesions treated with ZnSO4 and 36 patients with 53 lesions treated with Glucantime, 13 patients with 19 lesions and 22 patients with 31 lesions completed the trial, respectively. Inadequacy of treatment was the main reason for drop-out in 12 (33.3%) and 2 (5.5%) patients in ZnSO4 and Glucantime groups, respectively (P<0.05). Complete re-epithelialization was observed in 2 (10.5%) and 19 (61.3%) lesions 1 week after the end of treatment in the ZnSO4 and Glucantime groups, respectively (P<0.05).
    Conclusion
    A six-week course of weekly intralesional injections of 2% ZnSO4 solution was less effective than Glucantime in the treatment of acute Old World CL.
    Keywords: Clinical trial, Leishmania major, Cutaneous leishmaniasis
  • Pourpak Z., Mesdaghi M., Zarinara Ar, Shahabi Sh, Rajabi B., Heidar Zadeh M., Kazemnejad A., Kouhkan A., Kardar Gh.A Page 219
    Background
    Latex allergy is a major occupational disease with prevalence nearly 5-17% among the health care workers.
    Objective
    To determine the prevalence of latex glove allergy and its contributing factors among operation room staff. Patients and
    Methods
    In this study, 512 operation room staff were evaluated for latex allergy, using a complete questionnaire. Those suspected to have latex allergy underwent these tests: Eosinophils counting, measurement of serum total and latex specific IgE, latex skin prick test, latex and glove additives patch test.
    Results
    From evaluated staff, 178 (34.8%) had a history of sensitivity to latex gloves, from which 59 persons underwent the tests voluntarily. According to the results of the tests, 13 (22%) had type I allergy to latex, 3 (5.1%) had type IV allergy to latex and 9 (15.3%) had both allergies. There were no significant relationship between latex allergy and age, sex, job, season, family and personal history of allergies. Significant relationship was found between type I allergy to latex and allergy to kitchen gloves and also between type IV allergy and allergy to other plastic clothing.
    Conclusion
    Prevalence of latex allergy in this study is much higher than similar studies, which demands more evaluation to determine the contributing factors.
    Keywords: Allergy, Occupational diseases, Latex
  • Pourpak Z., Mesdaghi M., Zarinara Ar, Shahabi Sh, Rajabi B., Heidar Zadeh M., Kazemnejad A., Kouhkan A., Kardar Gh.A Page 231
    Background
    Latex allergy is a major occupational disease with prevalence nearly 5-17% among the health care workers.
    Objective
    To determine the prevalence of latex glove allergy and its contributing factors among operation room staff. Patients and
    Methods
    In this study, 512 operation room staff were evaluated for latex allergy, using a complete questionnaire. Those suspected to have latex allergy underwent these tests: Eosinophils counting, measurement of serum total and latex specific IgE, latex skin prick test, latex and glove additives patch test.
    Results
    From evaluated staff, 178 (34.8%) had a history of sensitivity to latex gloves, from which 59 persons underwent the tests voluntarily. According to the results of the tests, 13 (22%) had type I allergy to latex, 3 (5.1%) had type IV allergy to latex and 9 (15.3%) had both allergies. There were no significant relationship between latex allergy and age, sex, job, season, family and personal history of allergies. Significant relationship was found between type I allergy to latex and allergy to kitchen gloves and also between type IV allergy and allergy to other plastic clothing.
    Conclusion
    Prevalence of latex allergy in this study is much higher than similar studies, which demands more evaluation to determine the contributing factors.
    Keywords: Allergy, Occupational diseases, Latex
  • Barzegari M., Ghaninejad H., Shizarpoor M Page 237
    Background
    Psoriasis treatment is very important regard to mental sequeler and creating morbidity. First line treatment of generalized plaque type psoriasis includes methotrexate, phototherapy and retinoids.
    Objective
    To compare bath-PUVA and acitretin in the treatment of generalized plaque type psoriasis. Patients and
    Methods
    40 patients with generalized plaque type psoriasis with PASI scores of 15-20 in Razi Hospital in Tehran were randomly divided into 2 groups after giving consent. Each group included 20 patients. The first group was treated three times a week with bath-PUVA and the second group was treated with acitretin 0.7 mg/kg/day. The efficacy of 2 treatment regimens were determined and compared using PASI scores.
    Results
    The clearance rate was 65% in bath-PUVA group and 75% in acitretin group. Patients in bath-PUVA needed 29 sessions and accumulative dose of 105.46 J/cm² for clearance.
    Conclusion
    Psoriasis patients responded to bath-PUVA treatment but this response required more sessions and higher total dose. The inherent differences and distinctive responses to light in the patients under study (In Iran) compared with patients with skin phototypes I, II might explain these differences.
    Keywords: Psoriasis, Bath PUVA, Retinoids
  • Seylanian Toosi M., Homaiee F., Raziee Hr Page 242
    Background
    Neurofibromatosis 1 (NF1) is a relatively common autosomal dominant condition. Among the complications of the disease, such as neurological disorders, hypertension and skeletal deformities, malignancy is the most serious one and is the main cause of early death in these patients.
    Objective
    Review of cases of NF-1 associated with malignancies.Patents and
    Methods
    In a retrospective, descriptive study, 17 patients with malignancy and NF1 disease referred to oncology department of Qaem and Omid Hospitals (Mashhad) in a 10-year-period between 1993 and 2003 were reviewed.
    Results
    11 patients were male and 6 were female. The median age of patients was 23 years. We observed 9 cases with malignant peripheral nerve sheath tumors, 4 with CNS malignancies, 2 with rhabdomyosarcoma and one case with breast carcinoma.
    Conclusion
    Regarding the importance of early diagnosis of these malignancies, and especially considering the young age of involved patients, it is logical to plot a schedule to examine the NF1 patients periodically. Physicians who are in contact with these patients should educate them to be aware of any suspicious signs and symptoms of malignancy.
    Keywords: Neurofibromatosis type I, Malignancy, Autosomal dominant
  • Nabaie L., Shirzadian Kebria A., Gachkar L Page 247
    Background
    The need for a rapid, non-invasive method for unwanted hair removal has led to the development of various light sources for this purpose.
    Objective
    To evaluate the efficacy of Intense Pulsed Light Source (IPLS) on unwanted hairs. Patients and
    Methods
    In this open, uncontrolled clinical trial, 77 different anatomical areas in 34 referred patients to “Novin Didegan Clinic” in Tehran in 1380-1381, were treated by IPLS at fluences ranging from 22 to 34 J/cm² after their demographic data and the number of hairs were recorded. The 3 to 7 treatment sessions were accomplished 4 to 6 weeks apart. All of the patients were followed 6 months after the last therapy. The quantitative data were analyzed by paired t test.
    Results
    Six months after the last therapy, more than 50% reduction in number of hairs were noted in 80% of the treated areas; with mean reduction of 72±23 percent. Side effects were mild and reversible and occurred in ten patients.
    Conclusion
    The IPLS appears to provide an effective and safe method for long-term excess hair removal in various skin types.
    Keywords: Intense pulsed light source, Unwanted hair, Hair removal
  • Alizadeh N., Sadr Ashkevary Sh, Golchai J., Maboodi A., Falahati Aa Page 255
    Background
    In spite of prevention and control programs, dermatophyte infections have a high prevalence worldwide.
    Objective
    To do a descriptive study of dermatophytosis in Guilan. Patients and
    Methods
    217 patients whom were visited in Razi Hospital in Rasht in 1381 were screened for dermatophytosis and if had suspicious lesions, direct smear with KOH and culture were done.
    Results
    93 patients had positive smear (KOH 10%) and culture for dermatophytes. 50 patients were women and 43 patients were men. The most common patterns of dermatophytosis were tinea cruris (47.2%), tinea pedis (14%), tinea capitis (12.9%), onychomycosis, tinea manum, and tinea facei. Trichophyton mentagrophytes was the most common causative agent of tinea cruris that occurred more significantly in hot seasons.
    Conclusion
    Tinea cruris was the most common type of dermatophytosis in this study. High prevalence of tinea cruris specially in women in comparison to the previous studies, may be due to occupational activity (Agriculture) and clothing of women in north of Iran.
    Keywords: Tinea cruris, Dermatophytosis, Epidemiology
  • Barzegari M., Shams Davachi Sh, Kianfar A Page 261
    Background
    Prolactin, a neurohormone, can act as a stimulator of immunity in a number of autoimmune diseases and its high levels have been shown in these diseases.
    Objective
    This study was designed to discover the possible role of prolactin in autoimmune blistering skin diseases. The main goal was to compare the serum prolactin levels and the frequency of hyperprolactinemia in autoimmune skin patients with a control group. Patients and
    Methods
    Serum prolactin levels were measured in 44 patients with autoimmune blistering skin diseases and 44 age and sex matched normal persons.
    Results
    The mean serum prolactin level was higher in the patients group than the control group (13.7 ng/ml vs. 8.4 ng/ml). Seven of 44 patients (16%) had hyperprolactinemia, which was significantly higher than control group (P=0.006).
    Conclusion
    According to this study a higher frequency of hyperprolactinemia was observed in patients suffering from autoimmune blistering diseases in comparison with a control group.
    Keywords: Prolactin, Autoimmunity, Blistering skin disease
  • Rasi A., Soltani Arabshahi R., Safaie Naraghi Z Page 264
    Circumscribed juvenile pityriasis rubra pilaris (PRP) is a form of PRP that manifests with well-defined erythematous scaly plaques with follicular keratosis mainly over knees and elbows. There are several reports of the association of PRP with other conditions. We report a boy with scattered erythematosquamous skin lesions and follicular hyperkeratotic papules since the age of six years. Skin biopsy was compatible with PRP. He also had hypoparathyroidism and brachyonychia. To our knowledge, this association has not been reported so far.
    Keywords: Pityriasis rubra pilaris, Hypoparathyroidism, Brachyonychia
  • Akbari D., Balighi K Page 271
    Cutaneous larva migrans is a self-limited cutaneous eruption caused by larva of roundworms that do not normally parasitize humans. Ankylostoma brazielensis, the dog and cat hookworm, is the most common agent. The disease is found in tropical and subtropical regions and may be seen in travelers from these regions. We report a case of a 37-year-old Iranian man who had cutaneous larva migrans after traveling to Mexico. The patient was successfully treated with oral thiabendazole.
    Keywords: Cutaneous larva migrans, Foot, Thiabendazole