فهرست مطالب

Iranian Journal Of Dermatology
Volume:20 Issue: 1, Spring 2017

  • تاریخ انتشار: 1396/03/10
  • تعداد عناوین: 8
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  • Saman Ahmad Nasrollahi, Taraneh Yazdanparast, Setareh Ameri, Shadi Marami Zonouz, Mansour Nassiri-Kashani, Alireza Firooz Page 1
    Background
    Various fillers have been used for the correction of nasolabial folds. This study investigated the efficacy and safety assessment of two hyaluronic acid (HA) fillers on moderate nasolabial folds.
    Methods
    This study randomized 10 volunteers, aged 35 to 49 years, with moderate nasolabial folds. Volunteers received injections of HA A and HA B gels into the right or left skin folds. The volume and surface of nasolabial folds were analyzed using CSI computer software and high frequency ultrasonography of these folds before, and 2, 12, and 24 weeks after the injection. The obtained data were analyzed using SPSS software version 20. P≤0.05 was considered significant.
    Results
    Evaluation of the nasolabial folds before and after treatment showed significant reduction in volume of wrinkles 24 weeks after injection in both the HA gel A (-29.93±32%, P=0.022) and gel B (-23.60±26%, P=0.019). The surfaces of the wrinkles significantly decreased 24 weeks after injection of HA gel A (-29.90±31%, P=0.012) and gel B (-21.96±26%, P=0.026).
    Conclusion
    These HA fillers provided a significant, long-lasting correction of moderate nasolabial folds. Overall, we observed no statistically significant differences in any of the measurements between the 2 gels. However, there were more observed changes made by gel A compared to gel B.
    Keywords: clinical assessment, hyaluronic acid, nasolabial fold, filler, aging
  • Maryam Ghiasi, Maryam Daneshpazhooh, Kamran Balighi, Fatemeh Ghiasi Page 6
    Background
    Intravenous immunoglobulin (IVIG) is used to treat many autoimmune and immunodeficiency disorders. The main indications of IVIG in dermatology include treatment for resistant autoimmune bullous diseases, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Although generally welltolerated, various adverse effects can occur.
    Methods
    We designed a retrospective study to investigate the adverse effects of IVIG in all patients who received this drug in Razi Hospital from 2005-2016. Information was gathered from patients’ medical records.
    Results
    During the study period, 67 patients received 94 IVIG infusions. The most common underlying dermatologic disease was pemphigus vulgaris (54 patients). The most frequent adverse effect of IVIG therapy was an increase in blood pressure for 17 patients and in 21 infusions of IVIG. Other adverse reactions included fatigue and generalized weakness, fever, chills, tachycardia, dizziness, a decrease in blood pressure, headache, flushing, chest discomfort, hemolysis, leukopenia, and deep vein thrombosis.
    Conclusions
    Adverse events associated with IVIG therapy are usually mild and self-limiting. The incidence of serious adverse events is low. Identification of risk factors and close monitoring of high risk patients are essential to decrease the occurrence of serious adverse events.
    Keywords: intravenous immunoglobulin, adverse reaction, dermatologic disease, pemphigus vulgaris
  • Reza Yaghoobi, Nader Pazyar, Hooman Kalantari Page 11
    Background
    Lichen planus (LP) is a chronic inflammatory skin condition which leads to changes in lipid metabolism. It may cause chronic atherosclerosis and metabolic syndrome. The objective of this study is to compare lipid levels of patients with LP to healthy controls.
    Methods
    This case-control study recruited 100 total participants, 50 (25 male and 25 female) patients with LP and 50 healthy controls admitted to the Dermatology Clinic of Imam Hospital, Ahvaz, Iran. Serum triglyceride, total cholesterol, HDL cholesterol, and LDL cholesterol levels were measured in samples drawn after a 12-hour fasting period.
    Results
    Patients with LP had significantly higher triglycerides (147.7 vs. 118.4 mg/dl, P
    Conclusion
    This study showed an association between LP and dyslipidemia. Screening of serum lipids in patients with LP might be valuable to prevent cardiovascular diseases.
    Keywords: cardiovascular, cholesterol, dyslipidemia, lichen planus, triglyceride
  • Nessa Aghazadeh, Nooshin Rahnama, Saman Ahmad Nasrollahi, Ali Komeili, Alireza Firooz, Yahya Dowlati Page 15
    Background
    Iran has achieved rapid scientific growth in the past two decades. Considerable growth in scientific publications by Iranian dermatologists matches the pace of Iran’s scientific publications in the previous decade. In this study, we aim to identify the current trends in Iranian dermatology publications and authorship over the past decade.
    Methods
    We compared papers indexed in the MEDLINE database at two time points, 2004 and 2014, using the PubMed Search engine.
    Results
    We found 145 dermatology papers from Iran in 2014 compared to 31 papers in 2004, with an annual growth rate of 36.8%. There was a highly significant increase in the mean number of authors per article from 3.1 to 5.02 (P
    Conclusion
    The number of international publications by the Iranian dermatologist has proliferated during the past decade. Encouragement of international collaborations, production of high-quality and novel research, improvements to the standards and visibility of national journals, and higher adherence to authorship and publication ethics are essential perquisites for a more productive future for dermatology research in Iran.
    Keywords: publications, dermatology, research
  • Azita Nikoo, Zahra Naraghi, Kambiz Kamyab, Alireza Ganadan, Zohre Khodashenas, Azadeh Goodarzi, Fatemeh Mohaghegh Page 21
    Background
    Basal cell carcinomas (BCC) are the most prevalent among non-melanoma skin cancers (NMSC), which correspond to the most common skin cancers. BCC histopathological subtyping is a problem in therapeutic management. Therefore, we have decided to perform a histopathologic study for better classification of BCCs based on interobserver diagnostic judgment.
    Methods
    We conducted this cross-sectional study on 100 randomly selected pathologically confirmed BCC cases of various subtypes at Razi Hospital, Tehran, Iran during 2013 and 2014. A total of four dermatopathologists independently reviewed each pathology slide to evaluate the interobserver concordance rate.
    Results
    The overall Fleiss’ kappa statistic (kappa) for the BCC subtypes was 0.18 (P
    Conclusion
    Overall, we found that the dermatopathologists had inconsistent nomenclature for the BCC subtypes, however they had better agreement for the diagnosis of superficial, nodular, and infiltrative subtypes and the high risk growth pattern.
    Keywords: basal cell carcinomas, diagnostic concordance, histopathology subtyping, interobserver study
  • Nafiseh Esmaeli, Alireza Ghanadan, Parvin Mansouri, Forugh Ghaedi Page 26
    Necrobiotic xanthogranuloma (NXG) is a rare, progressive, non- Langerhans cell histiocytosis characterized by multiple yellowish indurated plaques and subcutaneous nodules that frequently involve the face, trunk, and extremities. Extracutaneous manifestations and paraproteinemia are common. Here, we report the case of a 47-year-old female who referred
    to the Dermatology Clinic of Razi Hospital, Tehran, Iran with complaints of a yellowish swelling on her right buttock after an intramuscular injection of penicillin. A similar lesion gradually developed on her supraorbital areas after several months. Histopathological findings included granulomatous inflammation of subdermal tissue with necrobiotic foci, which confirmed the diagnosis of NXG.
    The patient was treated with an intralesional injection of triamcinolone and oral prednisolone. After 12 months of treatment, the plaques became considerably flatter and smaller.
    Keywords: necrobiotic xanthogranuloma, injection, penicillin
  • Maryam Khalili, Saman Mohammadi, Mahin Aflatoonian, Hoda Badaksh, Fahameh Fadaei Resketi, Simin Shamsi Meymandi Page 29
    Darier’s disease results from abnormal keratinization of skin and is characterized by numerous keratotic papules that preferentially involve seborrheic areas. Kaposi’s varicelliform eruption (KVE) occurs by viral infections such as herpes simplex virus (HSV) in some inflammatory skin disorders like Darier’s disease. Herein, we describe a 68-year-old man, a known case of Darier’s disease, who presented with a sudden appearance of umbilicated vesiculopustular lesions on the face, trunk, and extremities.
    Diagnosis of KVE was confirmed by Tzanck smear and skin biopsy. Although the lesions resolved after oral acyclovir administration, the patient had recurrent episodes of KVE less
    than one month later.
    Keywords: Kaposi's varicelliform eruption, Dariers disease, viral infections
  • Rouhullah Dehghani, Rezvan Talaee, Javad Rafeenejad, Roya Seydi Rezvani, Fatemeh Karimi Page 32
    A 48-year-old woman who worked as a cleaner in a Kashan University of Medical Sciences dormitory received a spider bite while collecting garbage on a summer afternoon. She felt immediate irritation on her arm. She noticed a spider, which she removed and killed. The irritation, itching, and redness on her arm continued. Her hand became edematous and painful after four days and she suffered from insomnia. Her situation became worse to the extent that she was not able to move her fingers.
    The patient was hospitalized at Shahid Beheshti Hospital for four days due to the seriousness of her condition. During hospitalization, she received treatments that consisted of normal saline, corticosteroids, antibiotics, antihistamines, and analgesics after performance of any relevant tests. A tetanus vaccine and tetabulin were also prescribed. She had complaints of ongoing pain, swelling, itching, and redness for four days after which the patient was discharged with a prescription. The spider parts were sent to the laboratory for species analysis. The laboratory results diagnosed this spider as a member of the Loxosceles species. In most cases the cause of the bite disappears and is rarely detected. Here, although damaged, the laboratory could identify the spider.
    Keywords: spider bite, loxoscelism, brown widow spider