فهرست مطالب

Sciences, Islamic Republic of Iran - Volume:29 Issue: 4, Autumn 2018

Journal of Sciences, Islamic Republic of Iran
Volume:29 Issue: 4, Autumn 2018

  • تاریخ انتشار: 1397/06/21
  • تعداد عناوین: 6
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  • E. Darabi, N. Ebadi, S. Mehrabi, A. Shakoori *, M.R. Noori Daloii Pages 305-309
    The aim of this study was to examine the feasibility of using an economic and practical method in order to perform non-invasive prenatal testing of thalassemia as a sing gene disorder.Sixteen (16) pregnant mothers in the 11th week of pregnancy who were referred for prenatal diagnosis of thalassemia were selected. The parents had one of IVSII-1, IVSI-5 or FR codon 8/9 mutations. Enrichment of cffDNA was performed by a modified whole genome amplification. Based on the relative mutation dosage assay, wild and mutant alleles were compared by allele specific and Taqman allele specific real time PCR. The results obtained were compared with the results of invasive CVS. When both paternal and maternal mutations were identical IVSII-1 or FR codon 8/9, all three major thalassemic fetuses were detected by significant minus ∆Cts (Ct M-CtW) but no different ∆Cts was observed in seven cases in which fetuses were normal or carrier. In two cases with identical IVSI-5 parental mutations, the two major thalassemic fetuses could not be detected. In four cases with different paternal and maternal mutations, all three carrier fetuses were detected and in one major fetus, only paternal mutation was detected.This innovative method showed the detection of three of the five major thalassemic fetuses when the parental mutations were identical. Furthermore, paternal mutation inheritance could be determined in carrier or major thalassemic fetuses when the parental mutations were different. Further studies on fetuses in late gestational age may have more successful results.
    Keywords: Non-invasive prenatal testing, Beta-thalassemia, Enrichment, Modified whole genome amplification, Relative mutation dosage
  • F. Farzaneh *, E. Rashtizadeh Pages 311-319
    The Fe3O4@SiO2@APTMS@Glu-His@V complex was prepared with modification of iron oxide magnetic nanoparticles with (3-aminopropyl) trimethoxysilane (APTMS) and glutaraldehyde-L-histidine Schiff base followed by complexation with VOSO4. Characterization of the Fe3O4@SiO2@APTMS@Glu-His@V complex was carried out by means of FTIR, XRD, SEM, EDX, TEM, AAS and VSM techniques. It was found that Fe3O4@SiO2@APTMS@Glu-His@V complex successfully catalyze the epoxidation of allyl alcohols with tert-butylhydroperoxide (TBHP) in moderate to high yields. The epoxidation of geraniol with 100 % conversion and 100% selectivity within 15 min is remarkable. Short reaction time, high activity, selectivity, stability, reusability and easily magnetic separation of the catalyst with no leaching during the course of reactions are some advantages of this research.
    Keywords: Nanoparticles, Epoxidation, Vanadium complex, Allylic alcohols
  • J. Farzanfar, R. Rezvani * Pages 321-333
    The present study examined the effect of three methods of preparation on the properties and catalytic performance of Cu-Mn/SiO2 catalysts for the water gas shift reaction (WGSR). Impregnation and coprecipitation and the new approach of thermal decomposition of [Cu(H2O)6][Mn(dipic)2].2H2O/SiO2 inorganic precursor complex were used for the synthesis of the silica-supported copper-manganese mixed oxide catalysts. The calcined catalysts and the precursors used for their preparation were characterized by XRD, SEM, BET, TGA, DSC, and FTIR spectroscopy. The WGSR was assessed at 180 to 320 °C. The results showed that thermal decomposition of inorganic precursor complex is more convenient than impregnation and coprecipitation for preparing active and stable Cu-Mn/SiO2 catalysts for the WGSR.
    Keywords: Thermal decomposition, Complex, Bimetallic nanocatalyst, Low-temperature water-gas shift reaction
  • L. Firoozpour, A. Mokhtari, S. Moghimi, M. Safavi, A. Foroumadi * Pages 335-340
    Cancer is a leading cause of death worldwide. Many heterocyclic cores are present in the structures of clinically approved anticancer drugs. Meanwhile, benzothiazoles have been reported as one of the most important heterocyclic scaffolds in previously reported anticancer agents in the literature. Therefore, in this report, a novel series of 2-phenyl benzothiazole derivatives was synthesized, biologically evaluated against breast cancer cell line (T47D) and compared with etoposide as a reference drug. The anticancer activities were evaluated by MTT colorimetric assay. Among all tested compounds, N-(4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)acetamide illustrated the most potent cytotoxic activity.
    Keywords: Phenyl benzothiazole, Thiobenzanilides, Jacobson synthesis, Cancer
  • M. Noorizadeh *, A. Moradian, H. Ahmadipour, M. R. Ghassemi, J. F. Santos Pages 341-359
    The Hezar Igneous Complex (HIC) in the south-eastern part of Urumieh-Dokhtar magmatic arc, is the most prominent magmatic feature in the Kerman Porphyry Copper Belt, that understanding magmatic evolution of which may shed light on the tectonomagmatic development of this less-studied part of an important magmatic arc in the Neotethys realm. The HIC has been developed in the the intersection of the NS-striking Sabzevaran fault and the NW-SE striking Rafsanjan-Rayen fault. It is indicated that the possible place of the conduit and vent is in Jalas Mountain which has been splitted later by the Sabzevaran fault into Minor and Major Jalas. The current summit had been constructed by ascending magma chamber under the HIC that constitutes the Kamali Mountain at the south of the summit. Some plutonic rocks of the HIC are exposed at Kamali Mountain. The subalkaline rocks of this complex mainly are composed of different pyroclastic and lava flow rocks, acidic to basic in composition, showing the evidences of fractional crystallization and mineral segregation. Sequential explosive and effusive eruptions with Strombolian to Vulcanian types are evident in the successive volcanic layers. The compositional trend shows the melting of spinel lherzolite, not garnet lherzolite. The subduction-related mechanism of the magma genesis has been indicated by IAB nature of the magma formation in geochemical diagrams.
    Keywords: Hezar Igneous Complex (HIC), Rayen, Urumieh-Dokhtar magmatic arc, Tectonomagmatic evolution, Whole-rock
  • A. Khatoon Abadi, K. Yahya, M. Amini * Pages 361-368
    Wavelets and radial basis functions (RBF) have ubiquitously proved very successful to solve different forms of partial differential equations (PDE) using shifted basis functions, and as with the other meshless methods, they have been extensively used in scattered data interpolation. The current paper proposes a framework that successfully reconciles RBF and adaptive wavelet method to solve the Perona-Malik equation in terms of locally shifted functions. We take advantage of the scaling functions that span multiresolution subspaces to provide resilient grid comprising centers. At the next step, the derivatives are computed and summed over these local feature collocations to generate the solution. We discuss the stability of the solution and depict how convergence could be granted in this context. Finally, the numerical results are provided to illustrate the accuracy and efficiency of the proposed method.
    Keywords: Adaptive wavelet method, Radial basis functions, Perona-Malik equation