مجله دانشگاه علوم پزشکی قم
سال سوم شماره 1 (پیاپی 9، بهار 1388)

Background and Objectives The aim of this study was to investigate the effect of isolated soy protein on prevention of rheumatoid arthritis in collagen-induced rats. Methods A total of 24 female Sprague-Dawley rats (body weights: 180-200g) were randomly divided into four equal groups including normal; control of rheumatoid arthritis; rheumatoid arthritis + isolated soy protein (7g/kg); rheumatoid arthritis + dexamethasone (1mg/kg). Experimentally rheumatoid arthritis in rats was induced by subcutaneous injection of collagen ΙΙ emolsified in Incomplete Frund s Adjuvant in days 1 and 7. Treatments were gavaged to animals for 30 days once a day. The severity of rheumatoid arthritis symptoms in paws were daily measured in double blind format by standard method. The statistical comparison between the experimental groups was performed by Independent -samples t- test and One-Way ANOVA using SPSS software. Results The clinical symptoms of rheumatoid arthritis started from day 17.4±2.4 20±4 and 14.1±1.9 in isolated soy protein dexamethasone and control groups respectively (P

Background and Objectives Immunosuppression is regarded among the risk factors for bacterial infection. But in recent studies anemia was considered a predisposing factor for bacterial infections. The main goals of this study was to assess the rate of anemia in hospitalized patients with acute bacterial infection and to determine the relationship between anemia and bacterial infection as a predisposing factor. Methods 311 hospitalized patients whose bacterial infection was well documented based on the files present in Kamkar Arabnia Fatemi and Sahamieh hospitals in Qom Iran were selected for the present study. They were categorized into various age groups from newborns to the elderly. The data included age sex Hb of the patients the first third and discharge day HCT in the first third and discharge day MCV MCH MCHC WBC in the first third fourth day Diff in the first and fourth days ESR CRP maximum of fever and disease chronic disease smoking. A P

Article abstract:Background and Objectives As clinical improvement of patients surviving stroke is frequently incomplete and is followed by residual neurologic deficit evaluation of the consequent function of these patients in three respects i.e; physical social and emotional which are considered as quality of life is useful in decision making for health care providers. Since few studies have been carried out in this regard the aim of the present study was to obtain the average life quality score in four levels in aphasic stroke patients and comparing it with the quality of life score of the healthy population which is 5. Methods This study was a deh1ive-cross sectional research carried out on 105 aphasic stroke patients referring to medical centers in Hamadan Iran. Their diagnoses were confirmed by clinical and radiological findings. These patients were eligible for the study and had survived the stroke for at least six months. Sampling was non randomized and goal-oriented. Dependent variables included psychological communicational energy and physical status of the patients measured quantitatively. Data were gathered using the SAQOL-39 questionnaire. Results In this study the female population (58.1%) was greater than the male. The greater number of the aphasic patients (42%) was between 71 to 85 years old and the smallest number (6.7%) was between 39 to 50 years old. The greatest average score of life quality in the studied patients was related to the psychological state (2.17) while the smallest was related to the energy state (1.49). Average score of the life quality in the total population of the studied patients was calculated to be (1.88). Conclusion The findings of the present study can lead to special supportive measures with the aim of improving life quality in aphasic stroke patients. We suggest that life quality of the patient after stroke should be compared to his/her own quality of life before stroke. Because there is no special service for care providers of stroke patients an international program should be planned so that by reducing stress they could have a better relation with the patients.

Background and Objectives Autonomic system changes during ERCP lead to increased blood pressure(BP) and heart rate (HR) and decrease in arterial O2 saturation(SPO2). This study was carried out with the objective of evaluating the clonidine pre-medication effects on systolic BP HR and SPO2 during ERCP. Methods This randomized clinical trial study was conducted on 40 ERCP candidates. Patients were classified into two groups. The first group did not receive any premediacation. The patients of second group were given 0.2 mg clonidine 2 hours before ERCP. BP HR and SPO2 of all patients were recorded before during and after ERCP. The collected data were analyzed using chi-square t-test and repeated measures ANOVA (P0.05). Analysis of variance of systolic BP HR and SPO2 showed that SBP and HR changes were significantly lower in the clonidine group at different times (during and after endoscopy) {in the order P

Background and Objectives There has so far been controversy among researches about the effect of unilateral blunt testis trauma on structure and function of contra lateral testis. This study was designed to evaluate the effect of unilateral blunt testicular trauma after a time span of spermatogenesis (40 days) on the number of round and elongated spermatic cells spermatogonia primary spermatocyte sertoli and leydig cells of contra-lateral testis as well as to assess the protective effect of zinc on unilateral blunt testicular trauma. Methods In this experimental study 30 pre-pubertal male Wistar rats (age 7 weeks) were divided into three equal groups (n=10). Group 1(control) underwent a sham operation of the left testis under general anesthesia. Rats in group II and group III (with blunt testicular trauma) were subjected to left blunt testicular trauma to rupture the tunica albuginea. In group III just after the trauma 30 mg/kg zinc sulfate were given intra-peritoneally followed by admission of Zn for 40 days at a dose of 500 parts per million (ppm) /day orally. Later on all rats were sacrificed and their right testes were removed and after histological processing and staining by H & E method the samples were evaluated by counting round and elongated spermatid cells spermatogonia primary spermatocyte sertoli and leydig cells and also by cell structures study. Data were analyzed using ANOVA Tukey and Duncan's tests and pvalue of 0.05). Histological changes in sertoli and leydig cell were seen. Therefore the protective effect of zinc was not significant on germ cell proliferation and structure. Conclusion The results suggest that unilateral blunt testis trauma after time course of 40 days has no effect on germ cell layers and leydig and sertoli cells proliferation. This study suggests long term evaluation of testes after blunt trauma with use of electron microscope.

Background and Objectives Exercise seems to be a simple and widely practiced behavior that activates molecular and cellular signaling cascades involved in various central nervous system processes. There has been more attention to the effects of exercise on nervous system and memory during recent years. So we decided to examine the effects of treadmill exercise on memory consolidation and retrieval in young rats by passive avoidance learning. Methods In this study fifty male Wistar rats (3-4 months old) were randomly divided into five groups (n=10). Those in the control group were trained in passive avoidance box and tested 10 min 24 hrs 10 days and 3 months later. Two groups exercised in treadmill one hour at 17 m/min for 10 days and 3 months respectively and then were trained in passive avoidance box and tested 10 min and 24 hrs later. Data were analyzed using T and paired T tests. The other two groups for research effects of exercise in memory retrieval first were trained and tested 10 days and 24 hrs later and then exercised in treadmill like the other two groups; the latter groups were tested after exercise. Results The obtained results showed that short–term (10 days) and long – term(3 months) exercise before training had significant (P

Background and Objectives Experience with vesicoureteral reflux (VUR) differs in different centers and there are lots of controversies surrounding this issue. The aim of this study was to evaluate Spontaneous resolution and prognosis of the disease among Iranian children. Methods In this case series study 1278 children with urinary tract infection and visited at pediatric nephrology clinic in Tehran Iran during 1999-2007 were studied. Primary VUR was found in 533 Patients. Following the diagnosis the patients received prophylactic antibiotic and were annually followed with radionucleo cystography (RNC). Patients underwent surgery in case the medical treatment failed (breakthrough infection) or new renal scar formation. Results 533 patients with VUR were studied. Patients mean age with VUR was 3.7±2.4 years (range: 2 days to 18 years old). During an average follow-up duration of 3.3+2.2 years spontaneous resolution was observed in 40% of 279 patients who had follow-up RNCs. The mean interval between VUR diagnosis and spontaneous resolution was 1.5+ 1 years (range: 2 months to 6 years). The resolution rate was decreased with increment of reflux grade so that for grades I to V VUR was resolved in 63% 57% 27% 22% and 10% of the cases respectively. Anti reflux surgery was performed in 27(10%) of patients during follow-up. Conclusion Based on the excellent results obtained from clinical therapy using low dose antibiotics it is recommended that VUR grades 1 to 4 be managed medically with low-dose oral antibiotic prophylaxis and close follow-ups

Background and Objectives Adrenal myelolipoma is a rare benign condition. Most of these tumors are diagnosed as incidental findings during imaging. The asymptomatic patient with small lesion should be followed but the symptomatic patient with functional tumor and large lesion requires surgery. Case Report The 45 year-old male patient referred to the hospital. He was obese and suffering from back and left flank ache. He had also a history of hyper-lipidemia. He was sent for an Abdominal Sonogram and CT scan. Quite accidentally a huge mass with the dimensions of 22Í16cm and fat density within was observed in the right adrenal. Then the required investigations regarding hormonal activity were conducted. Finally due to the big size of the mass in order to prevent it from spontaneous rupture he underwent the right adrenalectomy operation