فهرست مطالب

Hormozgan Medical Journal - Volume:20 Issue: 4, Oct-Nov 2016

Hormozgan Medical Journal
Volume:20 Issue: 4, Oct-Nov 2016

  • تاریخ انتشار: 1395/08/18
  • تعداد عناوین: 8
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  • Sahereh Rouzbahan, Soheila Moein, Ahmad Homaei Pages 245-254
    Introduction
    Medicinal plants belong to Lamiaceae family are potential sources of new drugs to improve the treatment of diseases which its treatment is linked to anti-oxidative agents. In this paper, antioxidant potentials of some Lamiaceae species have been evaluated by two methods.
    Methods
    phosphomolybdate assay for total antioxidant capacity and ferric reducing antioxidant potential (FRAP) were used for evaluation of the antioxidant potentials of Zataria multiflora, Otostegia Persica and Salvia mirzayanii extracts and their fractions.
    Results
    The extracts and their fractions showed noteworthy activities in all antioxidant assays which compared to the reference antioxidant, ascorbic acid in a dose dependent manner. In FRAP method, ethyl acetate fraction of Salvia mirzayanii (SMA) and petroleum ether fraction of otostegia persica (OPP) possessed the highest and the lowest antioxidant potentials, respectively. In total antioxidant capacity, butanol fraction of Zataria multiflora and chloroform fraction of Otostegia persica were the in activist and the activist samples, respectively.
    Conclusion
    These results may show that these plants act as free radicals scavengers and antioxidant compounds.
    Keywords: Free Radical, Otostegia persica, Salvia Mirzayanii, Total Antioxidant Capacity
  • Fatah Moradi * Pages 255-262
    Introduction
    Interleukin-18 (IL-18) is a proinflammatory cytokine that is produced in adipose tissue and skeletal muscle. The circulating levels of IL-18 increases in obesity and some metabolic and cardiorespiratory diseases. The aim of the present study is to investigate the relationship between circulating levels of IL-18 and leptin, high-sensitivity C-reactive protein (HsCRP), blood pressure and cardiovascular function in obese and lean men.
    Methods
    In a descriptive-analytical study, 19 obese men (Body Mass Index (BMI)≥30 kg/m2) and 19 lean men (BMI≤18) were selected as subjects. After 12 hours of fasting, blood samples were collected and general characteristics of the subjects were measured. The Pearson’s correlation coefficient at a significance level of P
    Results
    Serum IL-18 levels in obese men were directly correlated with BMI and body fat percentage (BFP), but no significant correlation was observed in lean men. IL-18 in obese and lean men was directly correlated with leptin and HsCRP. But, it was inversely correlated with cardiorespiratory function (VO2max). IL-18 levels in obese men were directly correlated with systolic blood pressure (SBP), but no significant correlation was found between IL-18 levels and diastolic blood pressure (DBP). No significant correlation was observed between IL-18 levels and SBP and DBP in lean men.
    Conclusion
    It seems that changes in anthropometric characteristics, blood pressure, cardiorespiratory function and hormones such as leptin and HsCRP can be effective in IL-18 changes. These findings reveal the role of IL-18 in some inflammatory, metabolic (including diabetes and metabolic syndrome) and cardiovascular (hypertension pressure and atherosclerosis) disorders, especially in obese patients.
    Keywords: Interleukin-18_Leptin_C - Reactive Protein (CRP)_Blood Pressure_Obese
  • Sara Noshadi, Vali Alipour *, Mohsen Heidari, Kavoos Dindarloo Inaloo Pages 263-271
    Introduction
    Due to environmental and human health concerns related to humic acid (HA), mainly leading to disinfection by-products creation, removal or reduction of this matters is a necessary for drinking water suppliers. Based on resistive economy map road and move to self-sufficiency, it is necessary to produce our need in water treatment industry. One of the main consumed material is activated carbon that mainly imported to the country. In order to qualifying the produced activated carbon in HA adsorption, the present study was conducted to determine the capacity of powdered activated carbon (PAC).
    Methods
    A type of PAC was provided, then to finding the effective parameters in adsorption process, the tests of BET were done on samples; to determine special surface area (SSA), total pore volume (TVP) and mean pore diameter (MDP) of PAC pores. In a batch system, the experimental parameters were studied on 48 samples using the PAC which include; contact time (5-120 min), initial HA concentration (0.5-10 mg/L), initial adsorbent dose (0.5–20 g/L) and pH (3-11). Then the most conventional models for adsorption isotherm (Freundlich and Langmuir) and kinetic (pseudo first and -second-order) were evaluated.
    Results
    Based on BET test, the SSA was 161.53 m2/g, TVP and MDP were 0.2016 cm3/g and 4.9919 nm respectively. The maximum removal rate for HA was 97.65%, and the optimum conditions were as; equilibrium time of 10 min, initial HA concentration of 5 mg/L, adsorbent dose of 10 g/L and pH 7. The fittest adsorption isotherm and kinetic model were Freundlich isotherm (R2=0.963) and pseudo-second-order kinetic model (R2=0.999) respectively.
    Conclusion
    The results showed that produced PAC is able to remove HA as much as 97.65% in a reasonable time and dose range. Thus we can relying on production of this carbon, so it was no need of import of similar foreign products.
    Keywords: Natural Organic Matter, Powdered Activated Carbon, Adsorption
  • Mohammad Jebraeily *, Bahlol Rahimi, Khadijeh Makhdoomi, Farid Khorami Pages 273-279
    Introduction
    The hemodialysis patients face with multiple physical problems and psychosocial and social challenges. The proper interventions in the field of their education have a positive impact on the reduction of complications and improvement of the quality of their life. Despite the potential benefits of patient education, its success depends on various factors. The purpose of this study was determined present situation and factors affecting success of patient education in hemodialysis centers of Urmia University of Medical Sciences.
    Methods
    This is a cross-sectional descriptive study conducted in 2015. The study population included 420 patients in hemodialysis centers in Urmia University of Medical Sciences. Data were collected using a self-structured questionnaire which was estimated as both reliable and valid. The data were analyzed by SPSS 20 software descriptive statistics and analytical statistics.
    Results
    The most common of patients education methods in hemodialysis centers under study included handout-pamphlet (37%), oral conversation (26%) and workshop (18%). The most factors affective in hemodialysis patients education were related to patient education based on learning needs (4.85), ease of learning educational content (4.77), Proper communication between providers and patients (4.61), Skills of educators (4.50) and patient participation in the planning and implementation of education (4.44) respectively).
    Conclusion
    The hemodialysis patients need education in order to adapt to their condition and perform self-care behavior. So, physicians and nurses should provide education based on learning needs of patient through effectively communicating with patients and applying various methods. It is necessary that continuing education for healthcare provider conducted and also the quality of patient education evaluated and motivation of health care providers increased.
    Keywords: Patient Education, Factors Affecting, Success, Hemodialysis
  • Nooshin Taghinejad, Ahmad Alipoor *, Alireza Agha Yousefi, Farahnaz Mohammadi Pages 281-287
    Introduction
    Adolescence is associated with a change in self-concept made up of social interactions and experiences. Recent researches indicate the possible role of aggressive computer games on adolescents’ self-concept. The aim of this study is to evaluate the impact of violent computer games on the self-concept of second grade junior high school students in Bandar Abbas.
    Methods
    This is a quasi-experimental design study with pretest-posttest and control group. The sampling method is accidental sampling. 40 junior high school girls and boys as the clients of “KLICK” game net IN Bandar Abbas were selected as the control group. Participants responded to CSCS (Ahlo valiya) inventory and the experimental group played the aggressive game of Good nd evil. The obtained data were analyzed using SPSS software at the 0.05 significant level with t-test and multivariate analysis of variance with repeated measures and single variate analysis of variance.
    Results
    Multivariate analysis of variance showed that there is a difference between the boys and girls in the effects of computer games on self-concept (P
    Conclusion
    Due to the fact that adolescence is the period of evolution and growth of intellectual processes and given the fact that the intellectual and educational status of adolescents increases after doing the game, it is made clear that doing these games is beneficial for the academic and intellectual achievement of adolescents. In addition, due to the decrease of happiness among girls and increase of fame among boys after these games, it is recommended to give more notifications in line with more acquaintance of adolescents with the effects of these games.
    Keywords: Play, Aggressive Computer Games, Self-Concept
  • Meysam Rezaeishahmirzadi, Neda Motamedi Rad, Seyed Hamid Moosavy, Mohammad Shekari * Pages 289-294
    Introduction
    Peptic ulcer is a common problem in medicine with serious impacts on the quality of life of patients. It has been shown that Helicobacter pylori infection is related with inflammatory responses of gastric mucosa. However, some patients remain asymptomatic. Sustained colonization and chronic inflammation increase the risk of gastritis and peptic ulcer. The aim of this study is to investigate the genetic polymorphisms of inflammatory cytokine IL-10 and its relationship with peptic ulcer and gastric inflammation.
    Methods
    In this study, 107 people with symptoms of stomach pain and indigestion referred to a doctor with an indication for endoscopy were selected as the patient group. 107 healthy people without complications such as stomach pain and indigestion were selected as the control group. IL-10-592A/C polymorphism was examined by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP).
    Results
    No significant difference was found between the patients with peptic ulcer and chronic inflammation and healthy people in the control group in terms of the C allele in the IL-10 gene (P=0.99; 0.48-1.80, CI 95%, OR 0.93, and P=0.26; 0.57-1.13, CI 95%, OR 0.81, respectively).
    Conclusion
    The results showed no significant correlation between the inflammatory cytokine IL-10 gene polymorphisms and peptic ulcer disease and chronic inflammation.
    Keywords: Polymorphism, Interleukin, 10, Peptic Ulcer, Chronic Gastritis
  • Maliheh Morshedi, Ali Gol *, Aghileh Mohammadzadeh Pages 295-300
    Introduction
    Formation of gastric ulcer is a multifactorial process so that vascular changes, mucous secretion, gastric acid and gastrointestinal tract mucous biochemistry are involved in gastric ulcers. Despite therapeutic properties, ibuprofen as a non-steroidal anti-inflammatory drug (NSAID) can cause mucosal lesions in the stomach. In this study, the effect of Matricaria Chamomilla on the treatment of ibuprofen-induced gastric ulcers in animal models was examined.
    Methods
    In this experimental study, 18 male Wistar rats were divided into three groups of six rats. The gastric ulcer group received normal saline after inducing ulcers. Two experimental groups received Matricaria Chamomilla powder dissolved in normal saline after inducing ulcers. The animals were starved for 48 hours and then a single dose of ibuprofen (400mg/kg) was administrated orally. The animals were followed for two weeks to induce gastric ulcers. After inducing ulcers, the animals were treated orally with two doses of Matricaria Chamomilla (250 and 500mg/kg) for 10 days. At the end of the study, the animals were evaluated in terms of the number and extent of gastric ulcer. The data were analyzed with the help of SPSS using ANOVA and the nonparametric Kruskal-Wallis H test. P≤0.05 was considered as the significance level.
    Results
    The results showed that the mean number and surface area of gastric ulcers in the group receiving 500mg/kg of Matricaria Chamomilla were significantly decreased in comparison with the gastric ulcer group (P
    Conclusion
    Matricaria Chamomilla caused a dose-dependent gastric ulcer healing effect in animals
    Keywords: Matricaria Chamomilla, Ibuprofen, Gastric Ulcers, Rat
  • Seyedeh Parya Barzanjeh, Valiollah Dabidi Roshan* Pages 301-310
    Introduction
    Previous studies have confirmed the sidelong effects of Doxorubicin (DOX) on healthy tissues, but pretreatment effect of regular Aerobic exercise in restrain of hepatotoxicity induced by doxorubicin is not clear. The aim of this study was to investigate the pretreatment effect of regular aerobic exercise on hepatic oxidative stress induced with doxorubicin of Wistar rats in different age groups.
    Methods
    In the experimental study, Forty-eight male wistar rats divided into three groups of age (three and 29 months) were again randomly separated into subgroups: control೥ (20 mg/kg, n=8), and Training೥ (T೥栿, n=8) Training Saline (T) groups. The training protocol included treadmill running progressively between 25 to 54 min/day and 15 to 20m/min, 5 days/week for six weeks. DOX and saline injection was performed 24 h after the last exercise session, and tissue collection was done 24 h after the injections.
    Results
    The results showed that the DOX-induced did not significant effect on HSP70 of liver tissue of rats in different ages (young, middle-aged and elderly) (P=0.272). DOX-induced had a significant effect on MDA (P=0.002), PC (P=0.002) and GPx (P=0.001) of liver tissue of rats in different ages (young, middle-aged and elderly). Pre-treatment with aerobic exercise had a significant effect on changes of HSP70 (P=0.001), MDA (P=0.001), PC (P=0.001) and GPx (P=0.001) in DOX-induced liver in different ages rats (young, middle-aged and elderly. There was any significant difference between the levels of HSP70 (P=0.741), MDA (P=0.539), PC (P=0.075) and GPx (P=0.071) liver tissue in different ages (young, middle-aged and elderly) with pre-treatment and aerobic exercise.
    Conclusion
    Our study suggests that liver protection induced by chronically exercise in DOX treated rats is associated with inhibition of oxidative stress and increase in the efficiency of antioxidant system.
    Keywords: Exercise Training, Doxorubicin, Hepatic Oxidative Stress, Rats