فهرست مطالب

Hormozgan Medical Journal - Volume:20 Issue: 5, Dec-Jan 2017

Hormozgan Medical Journal
Volume:20 Issue: 5, Dec-Jan 2017

  • تاریخ انتشار: 1395/09/18
  • تعداد عناوین: 8
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  • Maryam Azizi, Minoo Rajaei, Aida Najafian, Shahram Zare, Maryam Iranfar*, Maryam Abbasian Pages 311-316
    Introduction
    The rate of cesarean delivery is increasing. Infection is one of the most frequent and important complications of emergency cesarean section. Infection prophylaxis has an important role to reduce post-cesarean delivery complication. The aim of this study was to compare the effectiveness of broad spectrum antibiotic prophylaxis (Azithromycin৪慪娭) with single agent antibiotic prophylaxis (Cephalotin) to prevent post-cesarean section infection in Shariati hospital patient since August 2012 to August 2013.
    Methods
    This clinical trial study was carried out in Shariati hospital of Bandar Abbas, Iran. 424 pregnant women were recruited and divided to two groups. Group 1 received Azithromycin and Cephalotin as a preoperative antibiotic prophylaxis and group 2 receives routine antibiotic regime (Cephalotin and placebo). To find any signs or symptoms of post-cesarean infection, patients were visited one mount after discharge. Collected data entered to SPSS software version 16 and descriptive and comparative test were performed.
    Results
    Our findings show that during one month after cesarian, in 4.3% (10 cases) of group 1 patients and 25.5% (55 cases) of group 2 patients, symptoms and signs of infection were observed. The difference between two groups was significant (P=0.000). We found no significant difference between demographic and other medical details.
    Conclusion
    Azithromycin have a significant effect on prevention of post-cesarean infection. Increasing the use of this broad spectrum agent as a part of antibiotic prophylaxis can decrease wound infection and other infectious complications of cesarean delivery.
    Keywords: Antibiotic, Section, Infection
  • Aida Najafian, Minoo Rajaei, Mojhgan Rahbar *, Amin Ghanbarnejad, Mehrdad Solati, Maryam Azizi Pages 317-324
    Introduction
    Gestational Diabetes Mellitus (GDM) is one of the complications of pregnancy that has some maternal and neonatal outcomes. Some drugs such as insulin and oral agents (metformin, ...) are used for management of GDM. The aim of this study was to compare metformin and insulin in treatment of GDM
    Methods
    This clinical trial was carried out in 2009-2011. Sample size was 201 patients. Patients were selected with Block permutation and divided to two groups, including 156 women treated with insulin and 51 with metformin. Single-blind for physicians, women treated with metformin, (500mg one or two times in a day). Insulin administration was according to multi day injection program and starts with NPH and regular Insulin. Blood sugar status of mothers and neonates and neonatal complications in both groups were followed up after discharge by telephone or direct interview.
    Results
    There were no statistically significant differences between both groups in maternal oral glucose tolerance test and FBS, and risk factors. No significant differences were seen in birth weight, head circumference, chest circumference, height, neonatal trauma, incidence of dystocia, neonatal trauma, respiratory distress, sepsis, fetus anomaly. The prevalence of first six months and second six months were similar in both groups but the prevalence of third six months and fourth six months were significantly increased in the group of women treated with insulin compared to women treated with metformin (P
    Conclusion
    Metformin therapy is clinically effective control of blood sugar in most of the women with GDM without any significant side-effects in the mother or in the fetus-neonate and it can be a safe alternative to insulin therapy.
    Keywords: Diabetes, Gestational, Insulin, Metformin
  • Aida Najafian, Minoo Rajaei, Saghar Beheshti* Pages 325-330
    Introduction
    This study was conducted to evaluate the efficacy of 800µg vaginal misoprostol after wetting alkaline PH vagina with 3% acetic acid in comparison with 800µg vaginal misoprostol alone in the alkaline PH vagina in terminating first trimester pregnancies.
    Methods
    In this clinical trial, a total of 100 healthy women between 20 and 40 years old requesting legal termination of pregnancy before 12 weeks gestation (98 missed cases 50 in group A and 48 in group B and 2 fetus with great anomaly in group B) were randomly assigned to either of the treatment groups to receive 800µg vaginal misoprostol after wetting vagina with three pieces of cotton soaked in 3ml of 3% acetic acid or 800µg vaginal misoprostol alone for induction abortion. Pregnant women with active vaginal bleeding, rupture of membrane, coagulopathy, corticosteroid consumption, previous cesarean section and any contraindication of misoprostol using were excluded. Duration of extraction or expulsion of the pregnancy product, complications, and treatment failure were collected. Data was analyzed using SPSS 19 by descriptive statistics and statistical tests comprising independent t-test and chi-square.
    Results
    Totally 14 patients had complete abortion (7 subjects in each group) and 86 had incomplete abortion (43 patients in each group). The success rate was not significantly different between both groups. The overall median induction-abortion interval was 19±14 hour.
    Conclusion
    Vaginal misoprostol in alkaline PH vagina wetted with 3% acetic acid was not significantly more effective than vaginal misoprostol alone in alkaline PH vagina in first trimester pregnancies.
    Keywords: Pregnancy Trimester First, Misoprostol, Acetic Acid
  • Soheila Ansari, Ali Gol*, Aghileh Mohammadzadeh Pages 331-339
    Introduction
    Acetaminophen is a widely used analgesic and antipyretic drug. Although it is considered safe at therapeutic doses, at higher doses, might produces a centrilobular hepatic necrosis that can be fatal. In the present study, the effect of fennel seed on hepatotoxicity induced by acetaminophen was investigated.
    Methods
    In this experimental study, forty-two adult male Wistar rats, weighing 250 to 280g, were randomly allocated into seven groups (n=6 for each group). After 24 hours of fasting, the control and control fennel (600, 1200mg/kg) groups, received normal saline, and the acetaminophen and acetaminophen緩 (300, 600, 1200mg/kg) groups received acetaminophen 1000mg/kg. After 6 hours, groups control and acetaminophen were given normal saline and groups control緩 (600, 1200mg/kg) and acetaminophen緩 (300, 600, 1200mg/kg) were given fennel seed powder in normal saline. Twelve hours later, liver peroxidase, catalase, malondialdehyde (MDA), hydrogen peroxide (H2O2) and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were assayed.
    Results
    In acetaminophen group, ALT, AST, MDA and H2O2 increased, and peroxidase and catalase activity decreased significantly compared to control. Fennel seed used in acetaminophen緩 (600mg/kg) group returned the changes toward control group.
    Conclusion
    The results suggest that fennel seed has a protective role in acetaminophen-induced hepatotoxicity.
    Keywords: Acetaminophen, Fennel Seed, Liver, Oxidative Stress, Rat
  • Leila Jamshidi*, Simin Hojjatoleslami Pages 341-347
    Introduction
    Association between plasma high-sensitivity C-reactive protein (CRP) concentrations and cardiovascular disease has been Investigated. C-reactive protein (CRP) is an acute phase reactant which is a marker of inflammation in the body. CRP is made by the liver in response to inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNFα). Adipose tissue is a major source of these inflammatory cytokines. The purpose of this study was, to examine differences in high-sensitivity C-reactive protein (hs-CRP) levels and body fatness.
    Methods
    A total of 260 adult healthy men and women were investigated in 2014. Body mass index (BMI) was measured for each participant. Blood samples were collected and CRP measurements were performed in the laboratory. Plasma CRP levels were measured by means of a colorimetric competitive ELISA. Data are expressed as mean±SD values. Relationship between obesity and CRP was analyzed by SPSS 20, and tested using χ2-test and logistic regression analysis.
    Results
    Subjects with elevated CRP had higher BMI and WC. For elevated CRP, subjects in the highest BMI quartile with subjects in the lowest BMI quartile. The result shows a relationship between CRP with BMI throughout the BMI spectrum. CRP levels were strongly correlated with BMI (P=0.0002).Levels of CRP also increased steadily across WC quartiles (P=0.0001). Waist circumference quartiles were also strongly associated with odds of elevated CRP. Women in the highest WC (91cm) and men in the highest WC (89cm) had an odd of elevated CRP.
    Conclusion
    Development and implementation of a global health strategy for prevention and control of non-communicable diseasesin recommended.
    Keywords: C- Reactive Protein, Obesity, BMI, Waist Circumference
  • Babak Nakhostin Roohi, Rasool Javanamani, Navid Zardoost *, Raziyeh Ramazanzadeh Pages 349-357
    Introduction
    The aim of this study was to evaluate effects of 7 day glutamine supplementation on exercise-induced oxidative stress and muscle damage.
    Methods
    Nineteen healthy, nonsmoking, young men were recruited to participate in this study. Participants were randomized in a double-blind placebo-controlled fashion into 2 groups: Glutamine (G group) (n=9) and placebo (P group) (n=10). Subjects consumed daily either glutamine (1.5 g/kg glutamine� water힘 sweetener) or placebo (250ml water힘 sweetener) for 7days. Then, participants ran 14km and were allowed to consume water throughout the exercise. Blood samples were taken before supplementation, before exercise, immediately, and 1h after exercise.
    Results
    Creatine kinase (CK) significantly increased in both groups after exercise compared with pre-exercise (P0.05).
    Conclusion
    It seems 7 day glutamine supplementation has been able to affect oxidative stress and muscle damage markers via possibly an effect on antioxidant agents.
    Keywords: Glutamine, Muscle Damage, Creatine Kinase (CK)
  • Behnaz Khoshnood, Farhad Handjani*, Hamid Goodarzi, Maryam Sadat Sadati Pages 359-363
    Introduction
    Cutaneous Leishmaniasis (CL) is characterized by papules, nodules or ulcers that most often leave permanent scars in exposed areas of body. This condition can have a severe effect on the quality of life in these patients. This study aims to examine the quality of life in patients with CL.
    Methods
    This cross-sectional study evaluated 120 patients (52 males and 67 females) between 16 to 80 years of age, with CL at Shiraz Valfajr health center, Shiraz, Iran. The Dermatology Life Quality Index (DLQI) questionnaire was used for measuring the quality of life. Data on demographics and characteristics of the lesions were also collected.
    Results
    The mean DLQI score was 11.7 with SD=7.15. The highest effect was observed in the realm of feelings, such as nervousness and feeling ashamed while the lowest effect was seen in the sexual relationship of patients. There was a significant difference in DLQI scores in patients with a high number of ulcerated lesions, especially if the ulcers or scars were on the face, than in other cases. Based on DLQI scores, lower quality of life was seen in CL patients. However, there was no significant difference in DLQI scores between men and women. In addition, no significant difference in DLQI scores were detected between other independent variables that were evaluated in this study.
    Conclusion
    Cutaneous leishmaniasis significantly affects the quality of life in these patients.
    Keywords: Cutaneous, Leishmaniasis, Dermatology, Quality of Life
  • Narges Khodabandeh, Farahnaz Mohammadi*, Nooshin Taghinejad, Fatemeh Jalali Pages 365-372
    Introduction
    Mothers who have children with mental and physical disabilities experience mental and social challenges. Recent researches indicate that Psychological status and marital satisfaction in mothers of children with mental retardation and mothers of children with physical disabilities is different. The aim of this study was to compare marital satisfaction and psychological characteristics of the mothers of children with mental retardation and mothers of children with physical disabilities.
    Methods
    This is a causal- effectual design study. The study population was all mothers of mentally retarded and physically disabled children that living in Bandar Abbas and their children have 5 to 12 years old. The sampling method was convenience sampling. 30 mothers of mentally retarded children and 30 mothers of children with physical disabilities were selected from two well-being and occupational therapy centers. Participants responded to psychological status (MMPI) inventory and marital satisfaction (MIS) inventory. The obtained data were analyzed using SPSS software at the 0.05 significant level.
    Results
    Mothers who have children with mental retardation, had significantly higher level of hypochondria, depression, hysteria, paranoia, schizophrenia, mania and lower maital satisfaction, than mothers of children with physical disabilities.
    Conclusion
    It seems that in addition to the type and severity of disability, spousal support, social support, parent s attitudes to type of disability can be affected on psychological characteristics and marital satisfaction in mothers. Conclusions are useful for families of exceptional children researchers.
    Keywords: Psychological Characteristics, Marital Satisfaction, Retardation