فهرست مطالب

Current Journal of Neurology - Volume:16 Issue: 1, Winter 2017

Current Journal of Neurology
Volume:16 Issue: 1, Winter 2017

  • تاریخ انتشار: 1396/01/24
  • تعداد عناوین: 11
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  • Payam Khomand, Ghobad Moradi, Behrooz Ahsan, Setareh Abtahi Page 1
    Background
    This study was performed to compare the effects of low dose interferon beta-1 (IFN-β-1) (CinnoVex, 30 mcg) and high dose IFN-β-1 (REBIF, 44 mcg) on the reduction of the number and size of plaques in magnetic resonance imaging (MRI) in patients with multiple sclerosis (MS).
    Methods
    This historical cohort study, which was performed in 2014 in Sanandaj (western part of Iran). 43 MS patients in two groups were investigated. The first group, which included 19 patients, was treated using high dose IFN (44 mcg) and the second group, which was consisted of 24 patients, was treated using low dose IFN (30 mcg). Patients’ data were collected and analyzed by the Stata version 11 software; the analyses were performed using statistical t-test, chi-square test, Fisher test, and logistic regression.
    Results
    Both drugs were effective in controlling active demyelinating plaque and in preventing plaque activation (P = 0.633). The impact of both drugs in the reduction of the number and size of plaques was evaluated. Based on the results of the MRI, high dose IFN therapy was more effective than the low dose IFN drugs and had a better performance in terms of reducing the number of plaques and in stop-and-recovery (P = 0.039), as well as in reducing the plaque size (P = 0.050).
    Conclusion
    The high dose IFN therapy was more effective than the low dose IFN therapy in reducing the number and size of brain plaques in patients with relapsing-remitting MS (RRMS).
    Keywords: Multiple Sclerosis, High Dose Interferon, Low Dose Interferon, Magnetic Resonance Imaging
  • Mozaffar Hosseininezhad, Hannan Ebrahimi, Seyed Mohammad Seyedsaadat, Babak Bakhshayesh, Motahareh Asadi, Amir Reza Ghayeghran Page 7
  • Seyed Ali Ghaffari, Maryam Nemati, H. Hajghani, Hossainali Ebrahimi, Abdolkarim Sheikhi, Abdollah Jafarzadeh Page 15
  • Kaveh Shafiei, Fatemeh Sedaghati Page 26
    Background
    Evidence-based medicine (EBM) is a current practice in medicine to produce clinical practice guidelines from well-designed, randomized, controlled trials. We studied knowledge, attitude, and practice of EBM of neurologists who participated in the Iranian congress of neurology.
    Methods
    A self-administered anonymous questionnaire was distributed and filled by neurologists.
    Results
    A total of 200 neurologists were randomly sampled and with response rate of 56%. 33.9% of responder had previously participated in EBM courses. The average total knowledge score was 4.05 ± 0.80 out of a maximum possible score of 5.0. Textbooks were still the most favorite source of knowledge for our neurologists. A lack of time was the highest, and motivation the least mentioned barrier in using EBM.
    Conclusion
    Overall, the Iranian neurologist had acceptable knowledge and attitude toward EBM and had same similar as found in other studies.
    Keywords: Evidence-Based Medicine, Knowledge, Attitude, Neurologist, Iran
  • Ehsan Kheradmand, Shaghayegh Haghjooy Javanmard, Leila Dehghani, Mohammad Saadatnia Page 30
    Background
    Activated protein C (APC) inactivates factor V (FV) by cleavage of its heavy chain at Arg306, Arg506, Arg679, and Lys994. Mutational changes, which abolish APC cleavage sites, may predispose thrombosis by altering the inactivation process of FV. FV Leiden (FVL) (Arg506Glu) has been demonstrated as a strong risk factor for thrombosis. In the current study, we have studied whether mutations in the cleavage sites of FV for APC, not due to FVL, would have a role in presenting APC resistance (APCR) and initiation of a cerebral thrombotic event.
    Methods
    A group of 22 patients with a history of cerebral venous thrombosis (CVT), who were not carriers of FVL enrolled in the study. The patients who had conditions associated with acquired APCR were excluded from the study. APCR test was performed on the remaining 16 patients, which showed APCR in 4 plasma samples. DNA sequencing was performed on four exons of FV of APCR patients, encoding Arg306, Arg506, Arg679, and Lys994.
    Results
    Mutations were not found within nucleotides encoding the cleavage sites; neither was found within their close upstream and downstream sequences.
    Conclusion
    Our results show that polymorphisms affecting cleavage sites of FV other than Arg506Glu it would be less likely to be the basis for APCR and its increased thrombosis susceptibility. In addition, it emphasizes on the importance of screening for APCR in the patients diagnosed with CVT.
    Keywords: Cerebral Venous Thrombosis_Factor V_Activated Protein C Resistance_Cleavage Sites
  • Mohammad Ali Sahraian, Mohammad Sahebkar, Rouhollah Dehghani, Milad Derakhshan Jazari, Vahid Kazami Moghaddam, Ebrahim Kouchaki Page 34
    There has been a global rising trend in recent years in the incidence of multiple sclerosis (MS). Despite being an MS low-risk region, this disease has also been recently on the rise in the Middle East. As part of the Middle East, Iran has not been spared either; however, the cause of this dramatic increase remains to be discovered. This study reviews possible reasons for this increase in Iran. Although many factors such as the increased rate of smoking, lifestyle changes, modernization, and contact with toxic solvents can be proposed as reasons for this sudden rise in the prevalence of MS in Iran, these factors cannot be taken as definite causes and further studies are required to prove their impact.
    Keywords: Multiple Sclerosis, Causality, Prevalence, Incidence, Environmental Factors, Iran
  • Sama Bitarafan, Kiana Amani, Mohammad Ali Sahraian, Payam Sarraf, Danesh Soltani, Abdorreza Naser Moghadasi, Mohammad Hossein Harirchian Page 41
  • Ahmad Reza Khatoonabadi, Shohreh Kaviani, Noureddin Nakhostin Ansari, Mahsa Saadati, Ehsan Shahverdi Page 43
  • Gholam Ali Shahidi, Mahdi Safdarian Page 53