مجله دانشگاه علوم پزشکی سبزوار
سال بیست و پنجم شماره 3 (پیاپی 98، امرداد و شهریور 1397)

The effect of the marker expression high molecular weight cytokeratin ) HMWCK ( in Benign prostatic hyperplasia (BPH) and adenocarcinoma prostate. There were conventional reported about rate expression HMWCK in adenocarcinoma prostate The purpose of this studied was to determine expression of the marker HMWCK with histopathological parameters in BPH and adnocarcinoma in prostatic by immunohistochemistry methods.

This descriptive analytical research was conducted on 79 patients admitted to Hospital in Isfahan Iran. Samples were fixed in formalin and tissue processing and stained by hematoxilin and eosin adenocarcinoma samples were classified with Gleason pattern ( score) method by two pathologist. The effect of over expression in marker expression HMWCK was done after diagnosis by two expert(blind). The obtained data were analyzed using chi-square test.

Out of the 79 specimens 43 samples were BPH and 36 samples were adenocarcinoma . in 40 samples with diagnosis BPH were observed of the marker HMWCK and 3 samples were negative. Out of 36 samples with diagnosis adenocarcinoma 35 them over expression marker of the HMWCK were negative but one samples was positive. . The over specimens malignancy were in higher Gleason score There was significant relationships between type samples (BPH and adenocarcinoma) with over expression of the marker HMWCK P

The aim of this research was to study the effects of eight weeks aquatic gymnastics Training on the Intensity of Low Back Pain in primiparous women.
This cohort study was carried out sampling primiparous women (n=62, age range: 28-35 year) in the second trimester of pregnancy were Purposefully selected and divided into two control (n=30) and experimental (n=32) groups. The experimental group performed a 8 week aquatic gymnastics Training both in water and land in the presence of the researcher, with the collaboration of aquatic gymnastics experts and under the supervision of a medical specialist at specialty hospital of Sarem (Tehran-Iran). The Qubeck low back pain standard questionnaire and Burg exercise intensity measurement scale were utilized to compare the results between the pre-/ post-test. The paired t-test and Covariance were used for analysis by SPSS V.19.
The results revealed that a 8 week aquatic gymnastics Training significantly relieved the low back pain and promoted the general health of the primiparous women during the second trimester of pregnancy (P=0.001). The back pain intensity was increased in control group (P=0/023).
Based on findings of the present study, as aquatic gymnastics Training can eliminate the low back pain and promote the general health among the pregnants, it can be suggested as a non-aggressive method

Target: Head lice infestation is worldwide and it is considered as an important health issue not only in deprived societies but also in developed countries societies as well. The object of this project is to investigate head lice prevalence in primary schools in Sabzevar city.
Research This study was of type descriptive and in form of sectional studies which was done in 2015-2016. The Target population was entity of primary school students and sample was 1200 people population. Sampling was of simple-random kind and checklist were used for data collection. Then Data was registered (recorded) in SPSS V 19 software. analysis of data was done according to chi-square test description.
The number of studied students was 1200, 30.9% were boys and 69.1% were girls. The highest prevalence of head lice infestations was in cases where their fathers were free (81.5%), and their literacy level (65.66%). There was no correlation between the type of residential home and contamination of the research samples (P = 0.71). There was no relation between the student's bases (P = 0.32), the existence of a health educator (P = 0.9) and father's occupation with head lice infection (P = 0.54).
Head lice infestation (Pediculosis capitis) is still a crucial health issue worldwide. It is recommendable that proper information is provided to primary schools teachers so that appropriate utilization of their capabilities in students’ instruction, screening & treatment (Therapy) is made possible.

A few studies have been carried out regarding the effect of air pollution on the sperm quality. All of these studies indicated the remarkable effect of air pollution on the men’s fertility abilities. The aim of this study was to investigate air pollution effects on sperm quality in the industrial zone of Asaluyeh.
This cross sectional study was conducted on 152 men that were recruited randomly through pollution (Asaluyeh) and control (Kangan) areas. Semen analysis was done for measure sperm quality. The Statistical analysis was performed using SPSS software and P

Portulaca oleracea is one of the most utilized herbs in the world. According to some antibacterial effect of plants extracts, it seems that this extracts can be used in the bacterial infection treatments. In order to assessment of antibacterial effect of the Portulaca oleracea extract, we determined minimum inhibitory and minimum bactericidal concentration of the Portulaca oleracea extract on the pathogenic bacterial species that antibiotic resistant pattern was determined in this species.
Hydro-Alcoholic extract of the Portulaca oleracea was harvested. Bacterial species including S. aureus, P. aeruginosa, L. monocytogenes, A. baumannii, E. coli and K. pneumonia was collected from the Iran pasteur institute. Antibiogram was determined by disk diffusion method and then MIC and MBC of Hydro-Alcoholic extract of the Portulaca oleracea was determined.
Highest MIC concentration was observed in P. aeruginosa, L. monocytogenes, E. coli and K. pneumonia. While highest MBC concentration related to L. monocytogenes.
Herbal antibacterial extracts can be useful in human infection control. In order to this goal, in this study antibacterial effect of Portulaca oleracea extract determined against six important pathogens. According to Our results hydro-alcoholic extract of Portulaca oleracea show antibacterial effect on human pathogens including E. coli, K. pneumonia, S. aureus, A. baumannii, P. aeruginosa and L. monocytogenes.

Nausea is a common symptom of general anesthesia and its control with non-pharmacological methods is one of the most important goals of nursing. one of the ways to increase the quality of nursing care is evidence-based method. The purpose of this study was to determine the effect of ambulation according to the evidence-based method on nausea in patients after inguinal hernia surgery.
This single-blind clinical trial was conducted on 60 patients who underwent inguinal hernia surgery in Shahrood imam-Hossein-Hospital in 1395. Patients were randomly divided into two groups: test and control.intensity of nausea was measured at 3,6,9 and 12 hours after surgery and before discharge time.The data were analyzed in SPSS16 using Fisher test, likelihood ratio, Kolmogorov Smironov,K2Pearson,K2Friedman,and Wilcoxon.
Findings: In first stage(before first ambulation), nausea intensity in experimental group was less than patients of control group(3.30VS3.57). In second stage (before second ambulation), nausea intensity in experimental group was less control group(3.03VS3.53). In third stage (before third ambulation), nausea intensity in experimental group was less than control group(2.73VS3.6).In fourth stage(before fourth ambulation), nausea intensity in experimental group was less than of control group patients(2.96VS3.63). In fifth stage (before discharge) nausea intensity in experimental group was less than patients of control group(2.03VS3.13).
according to results,an evidence based procedure is effective in reducing the intensity of nausea following inguinal hernia surgery.Considering the cost and fewer complications and ease of implementation of this method, it can be recommended as a care strategy in reducing nausea.

The present research is concerned with the role of mediating hardiness about early maladaptive scheme with cognitive emotion regulation in the case of women who have been abandoned by drug abuse disorder.
The purpose of this research is considered as fundamental research and the descriptive correlation method has been used.
The statistical population of this research is women in mashhad vakilabad central prison in1396, who have been abandoned by drug abuse disorder.
According to the official reports of Mashhad centeral prison, their number was 425, which 202 were randomly selected. Field method has been used to collect information and because of the subject nature, data was collected through questionnaire. Also, descriptive statistics and inferential statistics were used to analyze the data.
On the other hand, in order to confirm or reject the research hypothesis, the correlation method and the path analysis of multivariate regression was used.
It should be noted that all statistical analyzes have been used with SPSS software.

Chronic kidney disease as an important risk factor associated with some disorders including hypertension and heart failure which is the major cause of death and disability in older people. Hence, the aim of the present study was to investigate the effects of two types aerobic exercise on levels of apelin and its receptor in the old rats heart tissue with chronic kidney disease
Methods and Materials: In this experimental study, 28 aged male wistar rats )48 to 50 weeks) were selected and randomly divided into 4 groups: control, doxorubicin, doxorubicin-30minutes training and doxorubicin-60 minutes training. Chronic kidney disease induced by a single subcutaneous injection of doxorubicin (8.5 mg kg). The swimming training program includes 3 times per week, 30 and 60 minutes for 8 weeks. The levels of apelin and its receptor in heart tissue measured by using ELISA method. one-way analysis of variance was used to analyze the data)p

Congenital myasthenic syndromes (CMS) recognized as heterogeneous disorders arising from presynaptic, synaptic, or postsynaptic defects. Congenital myasthenic syndrome due to defects in synaptic activity of the acetylcholinesterase enzyme (AChE) is caused by recessive mutations in the COLQ gene. Ideal method for molecular diagnosis of this disease is direct analysis of the gene mutations, which is expensive and time consuming. Therefore, alternative methods such as linkage analysis using polymorphic markers including single nucleotide polymorphism (SNP) is suggested.
In this study, using bioinformatic analysis, rs2278961 marker located on 3'UTR of COLQ gene was selected which contains 2 alleles G and A. rs2278961 marker was genotyped in the Isfahan population by ARMS PCR technique, using specific primers. Degree of heterozygosity and allelic frequencies were calculated by Genepop software. Finally, the amount of polymorphism information content (PIC) was computed by PIC Calculator software.
According to the results of Genepop and PIC Calculator, the frequency of recessive allele A (MAF), the degree of heterozygosity and the PIC were estimated 0.539, 0.61842105 and 0.3735, respectively.
Since the MAF>0.2 and PIC close to 0.375 are the criteria for an efficient marker, rs2278961 having mentioned conditions, therefore it could be suggested as an appropriate markers for diagnosis of CMS disease in Iranian population.

Skin to skin contact in the first hours after birth, the mother and the baby is ready to establish a harmonized model for bilateral interaction. Few studies have been undertaken Kangaroo contact for term infants and assessing mother behaviors after birth. The aim of this study was to compare of mother and newborns abdominal skin to skin and Kangaroo skin contact on mothers attachment behaviors.
This single-blind clinical trial was accomplished on 68 qualified pregnant women, in Torbat Heydariyeh in 1394.women were randomly divided into two groups Experimental(Kangaroo skin contact)and control(abdominal skin contact).The attachment behaviors were been recorded at the first hour of visit of mother and infant for 15 minutes. Every minute divided into two 30 second that researcher observed the behaviors of mother in the first 30 second and recorded behaviors in 30 second during 15 minutes. After encoding the data, were analyzed with SPSS software version 20, Mann-Whitney tests, t, chi-square and kruskalwallis.0/05>p was considered significant.
Among emotional, proximity and caring behaviors for one hour after delivery in both groups, only proximity behaviors were significantly different (p=0.049).Two groups had not significant difference in mothers attachment behaviors in the first hours (p=0.134) after delivery.
The effect of Kangaroo skin contact on maternal attachment behaviors was similar to abdominal skin contact and in the comparison of abdominal skin contact had positive effects on proximity behavior.