Zahedan Journal of Research in Medical Sciences
Volume:19 Issue: 8, Aug 2017

In cervical cancer, more than any other type of cancer, the effects of prevention, early diagnosis and prompt treatment is apparent on reduction of mortality.
This study aims to achieve protein biomarkers which can be useful in diagnosis and treatment of cervical cancer.
In this Descriptive study, out of 3 patients who had a positive HPV PCR test, with symptoms of cervical tumor, samples of healthy and cancerous tissues were obtained to perform proteomics. By standard separation techniques, total tissue proteins were purified and separated by using two-dimensional electrophoresis.
Proteomes of healthy and cancerous tissues were compared with each other and the level of expression of considered proteins was evaluated using the required analyses. A total of 173 proteins in gels of two-dimensional electrophoresis was determined, 37 of which had a significant difference in expression. Because descriptive essay. We compared and statistical tests do not make sense.
It seems that in this disease, the expression of a large number of tissue proteins in cancerous tissue is changed, and most of them reduced or not expressed at all. These changed proteins can be useful as a marker in identification and treatment of this disease.

Multiple sclerosis is a potentially disabling disease of the brain and spinal cord (central nervous system) (CNS). Although the cause of MS is currently unknown, both genetic and environmental factors have been shown to contribute to the pathogenesis of MS. The human leukocyte antigen (HLA) class II alleles DRB1*1501, DRB5*0101, DQA1*0102, DQB1*0602 may have an important genetic effect. However, this is controversial in different population studies.
The aim of this study was to investigate the correlation of HLA DRB5*01 with MS in Khuzestan province.
The present case-control study focused on HLA DRB5*01 association in 202 MS patients from Khuzestan. Seventy four point two five percent (74.25%) of patients classified as relapsing-remitting and other patients were as primary-progressive, secondary progressive and progressive-relapsing MS. One hundred eighty seven persons that have no any inflammatory diseases investigated as control group. Polymerase chain reaction amplification method was performed to determine the type of HLA with sequence-specific primers (PCR-SSP). The frequencies of the mentioned allele were compared between the patients and control group using SPSS 21 statistical software and the chi square test.
Twenty- seven point seven two percent (27.72%) of patients and 21.39% from the control group were positive with this type of HLA.
This is the first study that investigate HLA DRB5*01 association with multiple sclerosis patients in Khuzestan. We found that there is no association between HLA DRB5*01 with multiple sclerosis in Khuzestan province (P = 0.148).

Reduced muscle strength due to aging may adversely affect the ability of the body in postural balance.
The aim of the present study was to numerically investigate the effects of aging on muscle recruitment patterns in keeping the balance during static standing posture.
In this numerical study, a total of 4096 static postures were considered by changing in the angles of three lower limb joints i.e. ankle, knee and hip in two complete human musculoskeletal models of young and old body with 44 muscles in the leg. Inverse dynamics approach was used to find the muscle activation in all postures. The joint mechanisms were assessed by considering the ratio between related muscle activities to the total activation.
Results showed that the muscle efforts in both models were posture-dependent and the knee played a relieving role specifically for the aged model. The possible postures that the young person could provide balance was wider than the elders. Also, the aged model expended more effort in doing the same tasks. The muscles revealed distinct joint mechanisms in the young model in contrast to the elders which used higher but non-distinguishable joint mechanisms.
Collaboration between the joint mechanisms was higher in the aged model but the young could more rely on individual mechanisms during static postural balance.

Gene ontology (GO) is a well-structured knowledge of biological terms that describes roles of genes and their products in a standardized and organized controlled vocabulary format. Over the last decade, many measures are developed to exploit GO advantages to determine semantic similarities between biological entities. Using GO ontologies, there are some constraints that existing GO-based semantic similarity measures try to address them. For instance, (1) edges in a GO graph, do not indicate uniform distances and also have different densities, and (2) ignoring term levels in an ontology makes “shallow annotation” drawback, i.e., two terms with a certain distance near the root of GO graph have equal semantic similarity with two terms with the same distance but far from the root.
Here, we present wAIC, a two-stage hybrid semantic similarity measure using weighted aggregation of information contents. In wAIC, the impact of each common ancestor on semantic similarity value is determined according to the location of the ancestor in the ontology graph. wAIC, also, filters (from annotating term set) terms that are in upper levels of the graph ontology to reduce shallow annotation constraints.
Experimental results confirm that the proposed measure is more consistent with major related constraints, such that, wAIC semantic similarity values have more correlation with both sequence similarity values and gene expression based similarity values than state-of-the-art semantic similarity measures.
WAIC show using a weighted aggregation of common ancestors is completely consistent with the human perception and can improve accuracy of gene similarity measurement.

Post-pneumonectomy chylothorax is a very common but serious complication.
A 43-year-old male with controlled hypertriglyceridemia, underwent off-pump coronary artery bypass grafting (OPCAB) with left internal thoracic artery and three saphenous vein graft on left anterior descending artery (LAD), left circumflex and right coronary artery subsequently. Preoperative medical history was unremarkable except to severe hyper triglyceridemia that treated by gemfibrizil. The early postoperative course was complicated by chylothorax. Chest X-rays showed blunting of left costo-phernic angle. On physical examination, a decreased respiratory sound was detected. The diagnosis of chylothorax was made by presence of milky fluid in the pleural cavity and laboratory finding of high content of triglyceride in the pleural fluid. On the following days, left pleural drainage was obtained by chest tube insertion, and low fat diet was instituted.
After ten days, the milky fluid drainage of chest tube ceased, the drains were removed and the patient was discharged with normal pulmonary expansion.