فهرست مطالب

Archives of Advances in Biosciences
Volume:9 Issue: 3, Summer 2018

  • تاریخ انتشار: 1397/06/06
  • تعداد عناوین: 8
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  • Mansour Amin, Asie Varnaseri Mohammadi, Mohsen Heidary, Saeed Khoshnood Pages 1-8
    Allium ascalonicum is a part of the diet of many populations of the world due to their long-held beliefs. A. ascalonicum extracts have been reported have antibacterial properties and prevent cancer cell proliferation. This study was conducted for the purpse of evaluating the anticancer and antibacterial activity of a flavonoid fraction isolated from A. ascalonicum bulbs. The HeLa and HUVEC cells were used as target cell line and some gram negative and positive bacteria were also targeted for antimicrobial activity. The A. ascalonicum plant was collected from the Zagros Mountains in the north of Dezful city- Iran, in September 2016 and confirmed by School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. The water extract of bulbs of this plant was extracted and the flavonoid fraction was isolated from aquous extract by ethyl acetate. The antibacterial and anticancer effects of isolated falavonoid were determined using MIC and MTT respectively. The best antibacterial effect of falvonoid extracted from A.ascalonicum was found against C. diphtheria. Furthermore, gentamicin resistant P.aeruginosa was the most resistant pathogenic bacterium. The MTT method showed that this fraction had a concentration-dependent anti-proliferative activity on HeLa cell lines and there was no cytotoxic effect against HUVEC cells. The inhibitory concentration 50% (IC50) values of the A. ascalonicum extract for Hela cell was 3 mg/mL but the treatment of HUVECs with the A. ascalonicum showed no considerable effect. The flavonoid fraction of A.ascalonicum bulbs had remarkable antibacterial and anticancer properties. Therefore, it could be used as an antibacterial and anticancer agent for control of cancers and infectious diseases.
    Keywords: Anticancer, Allium ascalonicum, Allium sativum, flavonoid
  • Masoumeh Navidinia, Khadijeh Gholinejad, Safoura Derakhshan, Ali Rahimipour, Faranak Kazerouni, Mohammad Ali Sahraian Pages 9-15
    Multiple Sclerosis (MS) is one of the autoimmune diseases which affects the central nervous system and its etiology has not yet been identified. The disparity between youth and disability in reproductive ages is considered to be of particular importance for this disease and the need for research which illuminates various epidemiological, etiologic, clinical and therapeutic angles of multiple sclerosis is deeply felt. The purpose of this study is to consider the epidemiology of microbial agents related to patients with multiple sclerosis (MS). From 37 patients with multiple sclerosis according to the physician examination and McDonald criteria , serum samples were taken. Until testing, serum samples were stored in a freezer at -70 ° C. Subsequently, viral and bacterial agents were identified using specific primers and PCR method. In this study, the numbers of microbial agents were as the following: 7 retrovirus associated with MS (MRSV), 17 EBV, 8 HSV6, 11 JC virus, 10 CMV, 8 B19, 14Corona virus, 1 Helicobacter pylori, 15 Acinetobacter, 9 Borrelia burgdorferi, and 19 Chlamydia pneumonia. Identification of the relationship between different infectious agents in MS is necessary to prepare feasible data about tracing and treatment of MS related to these microorganisms that may be beneficial to clinicians to select a convenient empirical therapeutic diet in MS related to pathogens at the bedhead and can open up a new path to new therapeutic approaches.
    Keywords: Multiple Sclerosis patients, Microbial Agents, PCR
  • Zohreh Abbasiyan, Maryam Shekofteh, Ebrahim Afshar, Erfan Ghasemi, Forough Rahimi Pages 16-22
    Plagiarism is one of the misconducts which are specifically observed in scientific journals. It is important to prevent and reduce it in scientific communities. The chief editors of journals can play an effective role in this regard. Therefore, this study aims to determine the knowledge, attitude, and the practice (KAP) of the chief editors of scholarly journals in Universities of Iran about plagiarism. The data for this descriptive survey were collected through a researcher-made questionnaire which was developed and validated in three sections of knowledge, attitude, and practice. The statistical population of the study included all the chief editors of scholarly journals in Universities of Medical Sciences in Tehran. The scores of the editors were calculated separately in each section. The data collection procedure was followed either by email or in-person. The collected data were analyzed through SPSS. The chief editors’ score is %88.8 in the section of “knowledge of plagiarism” which represents a high score. The chief editors’ “attitude toward plagiarism” indicates a high level (%61.3), which represents a negative attitude of plagiarism, and their “practice” is also at a mid-level approaching towards high level. In general, the knowledge, attitude, and practice of chief editors about plagiarism are in a better status comparing to similar studies. However, it is expected that the editors in chief achieve a more favorable level in this regard.
    Keywords: Plagiarism, scholarly journals, knowledge, attitude, practice
  • Saeideh Valizadeh, Haghi, Shahabedin Rahmatizadeh, Masoumeh Ansari, Ronak Hamzehei Pages 23-31
    When a new disease develops, people are looking for information about that disease where the internet is considered as one of the sources of health information. Beside empowering individuals to identify and select valid information, reliable and up-to-date websites should also be introduced for them. Therefore, the present study aimed to evaluate and identify the high quality websites on Ebola virus and disease. To do this study, the term "Ebola" was searched for in Google, Yahoo, and Bing search engines using the Google Chrome browser. Three pages were obtained from the search in these three selected search engines and were examined, with the exclusion of duplicate websites, non-English websites, the results related to news, images, ads, and inaccessible websites; finally, 43 websites out of the 90 retrieved websites were selected for evaluation. The research tools included the HONcode toolbar and an eight-item checklist was developed by the researchers based on the HONcode of conducts. The result showed that out of 43 websites evaluated, only 6 websites (14%) were trustable and the 86% were not approved after evaluation based on the HONcode criteria. Only 37% of evaluated websites have been considered complementarity criterion. Justifiability was the most considered criterion and 95% of evaluated websites had paid to distribute information fairly enough. Online information about Ebola is available on many websites and this information affects people's health decisions and behaviors. Physicians and other health professionals can help patients and other community members to find their needed information on infectious diseases (e.g. on Ebola) from the most reputable and valid international websites.
    Keywords: Patient Portals, Health Communication, Patient Education, HONcode, Ebola Virus Disease, website evaluation
  • Mahdie Behjati, Mostafa Sohrabpour, Seyed Pezhman Shirmardi, Fathollah Bouzarjomehri, Mohammad Amin Mosleh Shirazi Pages 32-41
    Elekta linear accelerator is equipped with a motorized wedge which produces the wedge angles of less than 60° continuously by the combination of a wedged field and an open field with appropriate proportions. The effective wedge angles for various field sizes and depths were calculated using an analytical formula and a 2-D array detector data. The validity of the effective wedge angles has been done by determining wedge angles in accordance with ICRU-24. The effect of the field size on the wedge angle and wedge factor was investigated for motorized wedge. The maximum difference between planned and measured angles was found to be about 10̊. The planned dose for different wedge angles and field sizes compared with measured doses and their differences were found to be less than 3%. The calculating wedge factor throughout linear interpolation method for all field sizes from a few selected measurements had been proved for physical wedge beforehand. This method was applied to obtain the wedge factors with field size and compared with measured data for motorized wedge. The errors were in agreement with ICRU proposed error and less than treatment planning system error. The linear relation between wedge angle and output factor and depth were investigated and the linear interpolation method was proved to calculate wedge angle for any output factor and depth.
    Keywords: Motorized Wedge, Wedge Angle, Wedge factor, Treatment planning
  • Shirin HassasYeganeh, Seyed Reza Hosseini Doost, Mehdi Goudarzi Pages 42-48
    Zingiber officinale as an herbal medicinal plant is used for its potential antimicrobial activity against different microbial pathogens. Multi-drug resistant Acinetobacter baumannii as an important nosocomial pathogen especially in intensive care units is responsible for a wide range of serious infections in humans. The purpose of this study was to investigate the antimicrobial activity of Z. officinale extracts on growth of A. baumannii strains isolated from hospitalized patients in intensive care units in Tehran, Iran. During a 9 month study, 50 multi-drug resistant A. baumannii isolates were recovered from patients in ICU. The Kirby-Bauer disk diffusion method was used to determine resistance patterns of Multi-drug resistant A. baumannii isolates to antimicrobial agents. Micro-broth dilution method was used to determine the antimicrobial activity of methanol, acetone, and chloroform extracts of Z. officinale against multi-drug resistant A. baumannii isolates. The results of susceptibility testing showed that all the isolates were resistant to ceftriaxone, ciprofloxacin, ceftazidime, cefotaxime, cefepime and piperacillin. Resistance to colistin was found to be low (4%) and exhibited good antibacterial activity against tested isolates. This study’s findings revealed that methanol, acetone, and chloroform extracts of Z. officinale have anti-bacterial activity against tested bacterial isolates. Based on the results, the chloroform extracted fraction showed the highest level of activity at a minimal inhibitory concentration of 25 mg/ml on multi-drug resistant A. baumannii (64%). The minimal inhibitory concentration of ginger extract was as low as 3.2 mg/ml. The present study indicated that Z. officinale extracts, at various concentrations could be used as an antibacterial agent for treatment of patients in ICUs.
    Keywords: Acinetobacter baumannii, Ginger, Antibacterial susceptibility
  • Saeid Ahmadi, Sajad Zare, Reza Ghanbari, Sahar Bahrami, Vida Zaroushani Pages 49-55
    The blood bank unit is one of the most important and fundamental units in every hospital especially in emergency situations. Lack of access to medical records related to individual’s blood transfusion can postpone blood transfusion when it is essentially needed which can in turn increase patients' risks. Meanwhile, the role of a blood bank information system is crucial in accessing this information, thereby improving the quality of available care. This research was conducted to determine the status of the blood bank information system of the hospitals affiliated to Shahid Beheshti University of Medical Sciences.This descriptive- practical study investigated the blood bank information systems of 11 hospitals affiliated to Shahid Beheshti University of Medical Sciences in 2015. Data collection was performed through observation and interview, using a checklist and questionnaire. The validity of the instrument was determined through content validity and its reliability was confirmed through retesting. Data analysis was conducted using descriptive statistics.All blood bank information systems under investigation were semi-mechanized. It was impossible to send the full reports electronically and to present dynamic reports. The blood bank staff were not aware of the existence and significance of the relevant standards and no specific blood bank software were used.Mechanized blood bank information systems bring about effective communication in various health care organizations. They lead to the application of relevant novel technologies while increasing patients’ safety and satisfaction.
    Keywords: Manual material handling, composite lifting index, risk of low back pain, lifting frequency
  • Farkhondeh Asadi, Azamossadat Hosseini, Alireza Kazemi, Forough Rahimi, Seylan Ghanyan Pages 56-62
    The blood bank unit is one of the most important and fundamental units in every hospital especially in emergency situations. Lack of access to medical records related to individual’s blood transfusion can postpone blood transfusion when it is essentially needed which can in turn increase patients' risks. Meanwhile, the role of a blood bank information system is crucial in accessing this information, thereby improving the quality of available care. This research was conducted to determine the status of the blood bank information system of the hospitals affiliated to Shahid Beheshti University of Medical Sciences.This descriptive- practical study investigated the blood bank information systems of 11 hospitals affiliated to Shahid Beheshti University of Medical Sciences in 2015. Data collection was performed through observation and interview, using a checklist and questionnaire. The validity of the instrument was determined through content validity and its reliability was confirmed through retesting. Data analysis was conducted using descriptive statistics.All blood bank information systems under investigation were semi-mechanized. It was impossible to send the full reports electronically and to present dynamic reports. The blood bank staff were not aware of the existence and significance of the relevant standards and no specific blood bank software were used.Mechanized blood bank information systems bring about effective communication in various health care organizations. They lead to the application of relevant novel technologies while increasing patients’ safety and satisfaction.
    Keywords: Blood bank information system, blood transfusion, blood bank, cross match, hospital