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Archives of Advances in Biosciences - Volume:8 Issue: 1, Winter 2017

Archives of Advances in Biosciences
Volume:8 Issue: 1, Winter 2017

  • تاریخ انتشار: 1395/11/05
  • تعداد عناوین: 8
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  • Somayeh Rastegar, Mohsen Gozari Pages 1-6
    In vitro assessment of the antifungal activities was evaluated in the present study for both aqueous and ethanol extracts prepared from leaves of Avicennia Marina and Rhizophora Mucronata. Leaves of mangrove species were collected from Qeshm and Syrik of south-east coast of Iran, mangrove forest respectively. Antimicrobial tests were carried out through disk diffusion method. Minimum fungicidal concentration was determined according to Agar Dilution method. Results showed that the ethanol extracts of both species had antifungal activities on P. pupurogenome, P. chrysogenum, P. notatum, A. niger, A. alternata and Penicillium italicum. However, none of the water extracts showed antimicrobial activity on the studied fungi. Among all pathogens tested, A. flavus was the most resistant fungi. Different concentrations of extracts from Avicennia Marina and Rhizophora Mucronata exhibited different degree of growth inhibition against tested fungal strains. This study indicates the capability of mangrove species for the utilization as source of natural antifungal.
    Keywords: Mangrove, Natural Antifungal, Postharvest, Pathogen
  • Maryam Shekofteh, Forough Rahimi Pages 7-16
    The increasing amount of scientific collaboration has led to an increase in the quality of scientific publications. The goal of this article is to analyze the co-authorship patterns and networks in SBUMS’s scientific publications in WOS from 2009 to 2013. Hence, the co-authorship indicators and ratio of national to international collaborations are determined. This research is a descriptive survey including scientometric approaches. HistCite and NWB software is used to draw and analyze the networks. The findings show that the scientific publications of SBUMS are 6633 publications. The most productive authors are Fereidoun Azizi and Mohammad Reza Zali. The maximum number of scientific publications is allocated to the articles written by more than 5 authors. Collaborative Index (CI), Degree of Collaboration (DC), and Collaborative Coefficient (CC) are 4.27, 0.96, and 0.71 respectively. The ratio of national to international collaborations is 4.78. In co-authorship networks, there are 12825 nodes (authors) that are linked with 97618 edges. The highest degree and betweenness centrality belongs to Masjedi showing the communication paths of other nodes overtaking them. The most international collaboration belongs to the USA. The collaboration of authors in SBUMS is almost good but the international collaboration is not so. Encouraging policies for the further collaboration of authors surely leads to increasing the quality and quantity of the scientific publications. It is recommended to repeat the network analysis in different periods of time.
    Keywords: Co, authorship Network, Scientific Collaboration, Network Analysis, Shahid Beheshti University of Medical Sciences
  • Hamid Mogaddasi, Azam Shahbodaghi, Masoud Amanzadeh, Mohammad Tabatabaei, Maryam Shekofteh Pages 17-24
    Minutes of educational councils in universities always contain valuable organizational knowledge and play an important role in micro and macro educational decision makings. Lack of storage system, organization and retrieval of these documents can be a major obstacle in the way of utilizing these precious documents. Designing and implementing of an appropriate software to manage minutes of educational councils can facilitate classifying these important documents and ease the access and visibility of their content as well. Therefore based on the structure and the content of educational council minutes of one school of medical sciences universities as a sample and the views of key stakeholders, researchers tried to design and implement a software for information and decisions management of minutes. This research is of developmental- applied type. In order to design the software, object-oriented analysis is used. In the analysis step, at first requirements are identified, extracted and defined based on the descriptive cataloging and subject analyzing of educational councils minutes and after final analysis, the required diagrams were drawn. Software architecture is determined based on the list of requirements and finally the drawn diagrams are converted to programming codes using C# programming language. In the end, the produced software has been tested to ensure its adaptation to the objectives of project and the defined requirements. In this study, it was tried that the designed software leads to the development of electronic database for minutes in order that the universities could have access to content and decisions of these meetings in due time and in appropriate manner. Despite the numerous capabilities of this software, it seems necessary that it be used more widely in order that we could review its improvement and optimization during its implementation in the actual operating environment. Subsequently, it is recommended that Universities of Medical Sciences use the software for information management and their educational meetings to facilitate the process of organizing, storing and retrieving of the documents. They can also contribute to the process of software upgrade for educational meetings in other universities.
    Keywords: Educational council minutes, Software development, Information management, Gray literature management, Medical Sciences Universities
  • Shahla Naeemi, Mohsen Bakhshandeh, Hojatolah Sabouri, Mehran Yar Ahmadi, Daem Roshani Pages 25-32
    Acute Radiation- induced Skin reaction (ARISR) is a common side effect in the majority of patients receiving radiotherapy. ARISR is often characterized by swelling, redness, pigmentation, dry and moist desquamation, edema, ulceration, bleeding and necrosis of the Skin. This study was carried out to evaluate prevalence and severity of ARISR in patients with head and neck cancer undergoing radiotherapy and determining skin dose–response relationship. From December 2014 to September 2015, we evaluated 88 patients with head and neck cancer. The acute skin toxicity was scored based on RTOG toxicity criteria. Analysis of data using statistical software SPSS (version20) and ANOVA or chi- square test was done, with P 0.05 considered as significant. 98.86% of patients experienced dermatitis, but were mild in most cases.There was no significant differences in age, sex, stage, and field size between patients with dermatitis.
    Keywords: Radiotherapy, head, neck cancer, acute radiation, induced Skin reaction
  • Parisa Nehzati, Mohsen Hamidpour, Davod Bashash, Mahin Nikoogoftar, Mohammad Reza Hedari, Ali Akbar Khadem Mabodi Pages 33-38
    The human scavenger receptor B1 (hSR-B1/CLA) is a HDL receptor with various anti-atherogenic functions which is expressed on the platelet surface. The anti thrombotic function of HDL includes the modulation of platelet reactivity, coagulation, and endothelial function. The goal of this study is to detect the level of HDL receptor on platelets of CAD patients with atherosclerotic disease. Expressions of the hSRB1 receptor on platelets of 31 CAD patients with atherosclerotic plaque and 20 healthy controls was detected using flow cytometry. Moreover, the lipid panel tests were assayed by Chemistry auto analyzer and compared with healthy controls. Our findings show that abundance of hSR-B1/CLA-1 was significantly reduced on the surface of platelets from CAD patients with atherosclerotic disease compared with healthy control (6/8 % vs. 13/6 %), (P
    Keywords: CAD, platelet, HDL receptor
  • Fatemeh Salarpour, Kourosh Goudarzipour, Ahmad Ahmadzadeh, Mohammad Hossein Mohammadi, Mehdi Allahbakhshian Farsani Pages 39-45
    P53 and AML1are two important tumor suppressor genes in regulation of hematopoiesis with a critical role in keeping balance between proliferation and differentiation. Alternations in the expression of these genes can be resulted in malignancy. The present study investigated the expression levels of P53 and AML1 genes in 82 de novo AML patient specimens against normal control group using Real-Time-PCR. The results presented in this study revealed that AML1 gene expression was significantly higher and P53 gene expression levels was significantly lower in patients with AML in comparison with the normal control group (P = 0.016 and P = 0.002). Furthermore, the correlation between P53 and AML1 was significant and positive (P= 0.037 and r= 0.231). The lower levels of P53 expression were expected and in line with the normal role of this gene as a tumor suppressor gene, however AML1 over expression was in contrast with of its well-known role in myeloid maturation. However, This findings suggest that despite the current established role this genes in myeloid cell differentiation, oncogenic form of AML1 (AML1a) has possibly increased and high expression of this isoform may act as an inhibitor for other normal AML1 isoforms and P53 as well.
    Keywords: Acute myeloid leukemia (AML), P53, AML1, oncogene, malignancy
  • Fatemeh Salmani, Alireza Abadi, Seyyed Mahmoud Taheri, Hamid Alavi Majd, Abbas Abbaszadeh, Hakime Sheikhasadi Pages 46-51
    Chest tube removal pain is one of the important complications after open heart surgery. The removal of a chest tube is a painful and frightening experience and should be managed with as little pain and distress as possible. The aim of this study is to assess the effect of beloved person’s voice on chest tube removal pain in patients undergoing open heart surgery. 128 patients were randomly assigned to two groups: one group listened to beloved person’s voice during the procedure, and the other did not. Since pain was measured by linguistic terms, a fuzzy logistic regression was applied for modeling. After controlling for the potential confounders, based on fuzzy logistic regression, the beloved person’s voice reduced the risk of pain. Therefore, using beloved person’s voice could be effective, inexpensive and safe for distraction and reduction of pain.
    Keywords: Beloved person's voice, Pain, Chest tube removal, Fuzzy logistic regression
  • Fattaneh Sabzehali, Hadi Azimi, Mehdi Goudarzi Pages 52-59
    Although the conventional therapies have obviously improved the conditions of patients with cancer, some mechanisms of resistance have led scientists to use alternative agents that can penetrate in most solid tumors. Furthermore, the success of cancer therapies depends on limiting the uptake of toxins to normal tissues and their selectivity to malignant cells. The involvement of natural and genetically modified non-pathogenic bacterial species, as potential antitumor agents, has led scientists to study bacteria and their products as an ideal vector for delivering therapeutic components to tumors. Moreover, bacterial ghosts, microbots, and bactofection are the other strategies to destruct the malignant tissues. Although it has shown to achieve successful results in vivo, further investigations on the targeting mechanisms of the bacteria are needed to make it a complete therapeutic approach in cancer treatment.
    Keywords: Bacteria, Cancer, Drug delivery