مجله علوم پزشکی پارس
سال چهاردهم شماره 1 (پیاپی 35، بهار 1395)

Zoonosis is common diseases between humans and animals & still considered one of the most important health problems. One of the zoonosis is brucellosis that is important in terms of health, economic and social.
This study is cross-sectional and prospective, data recorded during the years 2010 to 2014 in this city was covered health centers and laboratories. For data analysis used Spss software and was descriptive analysis and graphs.
267 cases registered in the years 2010 to 2014 revealed that 27.3% of females and 72.7% of males frequently mean age of the 33.68± 17.46 respectively. Most jobs involved with the disease of livestock and agricultural (38.8%) and household (21.1%). Respectively, fever (73%), anorexia (46%), myalgia (45.3%), back pain (34.4%) was the most common clinical signs were assigned to the investigation on the possible risk factors for patients showed that a history of contact with animals (75.5%) ,un pasteurization of milk(40.1%), un pasteurization cheese (31.8%), lack Vaccination of Animal (29%) had the highest frequency. The overall Prevalence during the years 2010 to 2014 was 14.67 per 100000 populations at risk.
Considering the high prevalence of the disease in this city, especially in rural areas and the high frequency of use of non-pasteurized dairy that showed is very important for this population. Another important point is cooperation between network of health and veterinary networks to encourage farmers for vaccinate livestock.

Ulcerative colitis (UC) is an inflammatory chronic disease that affects mucosa and submucosa of the colon and rectum. The etiopathology is related to imbalance of the mucosal immune respanse toward the resident bactorical flora together with genetic and envirmental factors. UC is thogather with annoying symptoms such as; abdominal pain, diarrhea, and rectal bleeding. In other hand plant of Dracocephalum polychaetum have used traditionally in treat of digestive tract disease and as tranquillizing. Therefore the aim of the present study, was to evaluated the effect of this herbal aqueous extract on a model of acute experimental colitis.
This experimental study were performed on 48 mail wistar rats(230-280g).Then induced ulcerative colitis, rats divided to groups incloude doses of extract (50, 100,200 mg/kg), vehicle,prednisolon and the last considered as control group.For induction of colitis the rats were fasted for 36 hours and then anaesthetized with CO2,at the last stage 2 ml of acetic acid 4% was instilled via the anus. After 24 hours the macroscopic study of colon showed the colitis indices. Biochemical evalution of inflamed colon was done using assay of myeloperoxidase (MPO) activity and rate of lipid peroxidation.
The aqueous extract of D.polychaetum with doses of (50(P>0/01),100(P>0/001),200(P>0/001)mg/kg) significantly reduced colon weight/length ratio. Extract at dose of 200mg/kg (P>0/05) was effective to decrease inflammation as well as extent of injury. Concentration of malondialdehyde (MDA) were increased in acetic acid-treated groups‚ while recovered by treatment of animals with D.polychaetum (200 mg/kg) (P>0/01) as well as prednizolon (10 mg/kg).
It is concluded that Dracocephalum polychaetum Burnm aqueous extract could be effective in treatment against experimental acute colitis. The results suggested extract had anti-inflammatory effect.

Group B Streptococcous (GBS) is a leading cause of neonatal infections such as meningitis and septicemia and plays a significant role in maternal infections including pyelonephritis, chorioamnionitis, and post partum infection. Diagnosis and treatment of these infections can reduce maternal and neonatal morbidity and mortality. So the aim of this study is Prevalence of Group B Streptococcus Colonization in The 35 - 37 weeks of Pregnancy referring to Honari clinic in Jahrom, 2014.
In this study, 403 pregnant women in The 35 - 37 weeks referring to Honari clinic in Jahrom, (after explaining the study, getting informed onsent and demographic informations) rectal and vaginal samples were taken. The samples were placed in transport media, transported to the Laboratory and tested for GBS. Data were analyzed by SPSS software, Fisher tests and Chi square
In this study, the prevalence of positive vaginal, rectal and rectovaginal GBS culture in pregnant women were 16.4%, 5.2% and 1.7% respectively. There werer significant correlation found between this positive cultures and maternal age, genital diseases status and pregnancy induced hypertension, but no significant correlation found between this positive cultures and abortion status, diabetes mellitus, Disease after birth mom status, Preterm delivery, Urinary infection status, Location, Nationality, education level, disease after birth in The baby and section.
According to the high prevalence (19/9%) GBS colonization in pregnant women in Jahrom should present appropriate solutions for the prevention of invasive infection in mothers and infants infected.

Toluene (C7H8) is an aromatic compound and part of the structure of petroleum, which is mainly used as a chemical solvent in the industry. Being harmful to the environment and with respect to the increasingly use and side effects, this substance and its impact on blood and lunges tissues, have been studied on in this study.
Material and 30 mature Albino NMRI mice have been experimented in three groups of Shem, Group-A, which has been injected with the 0.1 cc Toluene solution (35% Toluene and 65% physiologic solution) with the purity of 1700 mg/kg for 25 days and Group-B with the same weight of the mice and the same situation except the purity which has been changed to 1000 mg/kg. After weighting, anesthesia and taking blood samples, relative parameters of blood and lung tissues were considered, measured and studied in the scope of micro and macro.
Reasalt: In the Group-A the percentage of Neutrophil have been reduced and the number of degenerated Lymphocytes and other leukocytes have been enhanced. In lung's tissues the mean thickness of bronchi walls, the overall diameter of bronchioles end, breathing bronchiole, and the thickness of the Alveoli septa in group-A have shown improvements, also pneumocystis1 cells and pneumocystis 2 cells have been raised and reduced respectively. At all the mentioned parameters there are meaningful relations between A and B and shame, with a P By stimulating Blood makingcenters, Toluene causes changes in the number and the percentages of leukocytes and by raising the thickness and the diameter of parameters of lungs, causes breathing weakness and the reduction of its performance. These impacts are dependent to the dosage of the Toluene of which the high purity has shown much more damage.

Respiratory distress is the most frequent cause of admission in NICU. Immediate differentiate between cardiac and non-cardiac causes, could influence course of treatment. The aim of this study is to evaluate necessity of echocardiography in evaluation of neonates with respiratory distress in NICU.
This retrospective study was performed on 349 neonates admitted due to respiratory distress in the NICU of Izadi and Hazrat-e-Masoumeh hospitals in the city of Qom in 2013. Data was collected and analyzed by chi-square test and t-test using SPSS software.
15% of respiratory distress cause was extra pulmonary and most common causes were sepsis. Echocardiography was done for 55.3% of neonates. Among cardiac cause of respiratory distress, large and very large PDAs (27.3%), large ventricular septal defect (22.7%) and dTGA (18.2%) were most common causes. Gender of infant, type of childbirth, season of birth, length of hospital stay and the 5-minute Apgar score was not significantly different among cardiac and non-cardiac causes, but gestational age and age of infants was significantly higher in babies with cardiac disease.
It seems, in addition to current criteria (respiratory distress and murmurs) to decide for echocardiography, term neonate and older infants should also be considered. prolonged respiratory distress and murmur, cardiac causes may be considered in.

The purpose of this study, the preventive effect of 3 and 6 weeks of aerobic training on HSP72 and CAT liver levels in rats following acute administration of Doxorubicin at doses of 10 or 20 mg per kg.
The study population consisted of 72 male rats for 60 days to randomly were classified into two groups practice. The exercise groups divided were into groups of 3 and 6 weeks training. At the end of the exercise training group was also randomly into the following groups (10 mg kg dose of doxorubicin and doxorubicin dose of 20 mg per kg and saline) divided were. After 24 hours, the last training session, the specified dose of doxorubicin (10 and 20 mg kg) and saline 0/9 percent were injected as follows. After the biopsy, the ELISA was used to measure levels of HSP72 and CAT liver.
A significant increase in HSP72 levels in the Group C / DXR20 compared to C / SAL was seen. Injecting a dose of 20 mg per kg after 3 and 6 weeks of training is a significant increase compared to the CAT (3wEX / SAL) and (6wEX / SAL) was.
The use of non-pharmacological methods such as medium-term and short-term resistance exercise before Injecting drug doxorubicin can reduce oxidative stress by increasing the support mechanisms to reduce drug-related liver toxicity and a proactive approach before treatment doxorubicin to be used.

The incidence of resistance to groups of beta-lactam antibiotics has become one of the most common cases. This problem too many seen in hospital pathogens, that including coagulase-negative Staphylococcus. Therefore, distinguish of resistance factors can be helpful in treatment process. The aim of this study was to determine resistance in coagulase-negative Staphylococcus by phenotypic and genotypic ways.
Totally, 710 isolates from clinical samples reaped of health centers of Zahedan. After the determination genus and species of isolates obtained, their sensitivity specify to 10 beta-lactam antibiotics by disc diffusion method. For detection of blaZ and mecA gens used of specific primers and PCR method.
Of obtained isolates, 79 isolate was Staphylococcus saprophyticus and 198 isolate was Staphylococcus epidermidis. Of these, 74 isolates (98.1%) to penicillin, 69 isolates (34/87%) Oxacillin, 31 isolates (24/39%) to ceftriaxone, 71 isolates (87/89%) to Cefoxitin, 43 isolates (43/54%) to cefotaxime, 19 isolates (24.50%) to cefazolin and 27 isolates (17/34%) were resistant to cephalexin in Staphylococcus saprophyticus. PCR results in more isolates confirmed the presence of mecA and blaZ.
The Primary screening by phenotypic disk diffusion method showed high prevalence of resistance in the city of Zahedan and was determined that 20 to 95 percent of the isolates were resistant to all beta-lactam of different generations. PCR method approved presence of the mecA and blaZ genes. But those expression is different. This payoff achieving that singly disk diffusion phenotypic method lack of for determining strategy is not appropriate to treatment of infections caused by this organisms.

After malaria, Cutaneous Leishmaniasis is the most important parasitic disease in tropical and semitropical areas of the world. One the most effective ways of controlling Cutaneous Leishmaniasis is practicing preventive behaviors by family persons. Since of the endemic disease in Kherameh, this research performed aimed the impact of factors related to preventive behaviors of Cutaneous Leishmaniasis among families Kherameh city in 1394.
In this cross sectional descriptive-analytic study that statistical population is city Kherameh families. Using Cochran's formula 350 families were chosen as study sample. The instrument used in this research was questionnaire. The validity of the questionnaire was confirmed by experts and the reliability was 79%. The questionnaire was completed by mothers in participating families .In order to analyze the data, using SPSS software version 16 and Spearman correlation coefficient and chi-square and ANOVA tests were used.
mean and standard deviation of participants was 36/01 ± 12/25 years, Mean and standard deviation performance of City managers: 13/75 ± 10/59, Public media (TV and radio): 7/77±8/57, Mean and standard deviation performance of health volunteers was 4/77±10/29.
The results showed that the performance of radio and television, health volunteers and city managers is low. Public media and health volunteers with continuous training and city managers with proper operation can be an effective step in promoting preventive behaviors of Cutaneous Leishmaniasis in the population.