فهرست مطالب

Archives of Iranian Medicine
Volume:20 Issue: 7, Jul 2017

  • تاریخ انتشار: 1396/04/28
  • تعداد عناوین: 9
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  • Shirin Djalalinia, Sahar Saeedi Moghaddam, Maziar Moradi-Lakeh, Saeid Shahraz, Mohsen Naghavi, Christopher Jl Murray, Theo Vos, Ali Mokhdad, Kris Krohn, Goodarz Danaei, Farshad Pourmalek, Alireza Esteghamat, Nazila Rezaei, Nima Hafezi-Nejad, Sara Sheikhbahaei, Farshad Farzadfar* Page 392
    Background
    Due to significant achievements in reducing mortality and increasing life expectancy, the issue of disability from diseases and injuries, and their related interventions, has become one of the most important concerns of health-related research.
    Methods
    Using data obtained from the GBD 2015 study, the present report provides prevalence and years lived with disability (YLDs) of 310 diseases and injuries by sex and age in Iran and neighboring countries over the period 1990–2015. Age-standardized rates of all causes of YLDs are presented for both males and females in 16 countries for 1990 and 2015. We present the percentage of total YLDs for 21 categories of diseases and injuries, the percentage of YLDs for age groups, as well as the ranking of the most prevalent causes and YLDs from the top 50 diseases and injuries in Iran.
    Results
    In 2015, the burden of 310 diseases and injuries among the Iranian population was responsible for 8,357,878 loss of all-age total years, which is equal to 10.58% of total years lived per year. This differs from the neighboring countries, as it ranges from 9.05% in Turkmenistan to 13.36% in Russia. During the past 25 years, a remarkable decrease was observed in all-cause YLD rates in all 16 countries. Meanwhile, in all countries, the age-standardized rate of all causes of YLDs was higher in females than males.
    Conclusion
    Based on our findings, one of the remarkable changes in NCDs observed among the studied age groups was increased rate of YLDs from mental disorders, which was replaced by musculoskeletal disorders in older age groups in 2015.
    Keywords: Global burden of disease (GBD), Iran, prevalence, years lived with disability (YLDs)
  • Sadaf G. Sepanlou, Mahboubeh Parsaeian, Kristopher J. Krohn, Ashkan Afshin, Farshad Farzadfar, Gholamreza Roshandel, Chante Karimkhani, Sharzad Bazargan-Hejazi, Aliasghar Ahmad Kiadaliri, Hamid Ahmadieh, Mohsen Naghavi*, Shirin Djalalinia, Hedyeh Ebrahimi, Babak Eshrati Page 403
    Background
    Summary measures of health are essential in making estimates of health status that are comparable across time and place. They can be used for assessing the performance of health systems, informing effective policy making, and monitoring the progress of nations toward achievement of sustainable development goals. The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) provides disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) as main summary measures of health. We assessed the trends of health status in Iran and 15 neighboring countries using these summary measures.
    Methods
    We used the results of GBD 2015 to present the levels and trends of DALYs, life expectancy (LE), and HALE in Iran and its 15 neighboring countries from 1990 to 2015. For each country, we assessed the ratio of observed levels of DALYs and HALE to those expected based on socio-demographic index (SDI), an indicator composed of measures of total fertility rate, income per capita, and average years of schooling.
    Results
    All-age numbers of DALYs reached over 19 million years in Iran in 2015. The all-age number of DALYs has remained stable during the past two decades in Iran, despite the decreasing trends in all-age and age-standardized rates. The all-cause DALY rates decreased from 47,200 in 1990 to 28,400 per 100,000 in 2015. The share of non-communicable diseases in DALYs increased in Iran (from 42% to 74%) and all of its neighbors between 1990 and 2015; the pattern of change is similar in almost all 16 countries. The DALY rates for NCDs and injuries in Iran were higher than global rates and the average rate in High Middle SDI countries, while those for communicable, maternal, neonatal, and nutritional disorders were much lower in Iran. Among men, cardiovascular diseases ranked first in all countries of the region except for Bahrain. Among women, they ranked first in 13 countries. Life expectancy and HALE show a consistent increase in all countries. Still, there are dissimilarities indicating a generally low LE and HALE in Afghanistan and Pakistan and high expectancy in Qatar, Kuwait, and Saudi Arabia. Iran ranked 11th in terms of LE at birth and 12th in terms of HALE at birth in 1990 which improved to 9th for both metrics in 2015. Turkey and Iran had the highest increase in LE and HALE from 1990 to 2015 while the lowest increase was observed in Armenia, Pakistan, Kuwait, Kazakhstan, Russia, and Iraq.
    Conclusions
    The levels and trends in causes of DALYs, life expectancy, and HALE generally show similarities between the 16 countries, although differences exist. The differences observed between countries can be attributed to a myriad of determinants, including social, cultural, ethnic, religious, political, economic, and environmental factors as well as the performance of the health system. Investigating the differences between countries can inform more effective health policy and resource allocation. Concerted efforts at national and regional levels are required to tackle the emerging burden of non-communicable diseases and injuries in Iran and its neighbors.
    Keywords: disability, adjusted life, year, global burden of disease, healthy life expectancy, Iran
  • Maziar Moradi-Lakeh, Sadaf G. Sepanlu, Seyed M. Karimi, Narjes Khalili, Shirin Djalalinia, Chante Karimkhani, Kristopher Kohn, Ashkan Afshin, Farshad Farzadfar, Aliasghar Ahmad Kiadaliri, Mohsen Asadi-Lari, Hamid Asayesh, Alireza Esteghamati, Maryam Farvid, Mohsen Naghavi* Page 419
    Background
    The Global burden of disease and injuries study (GBD 2015) reports expected measures for years of life lost (YLL) based on socio-demographic index (SDI) of countries, as well as the observed measures. In this extended GBD 2015 report, we reviewed total and cause-specific deaths and YLL for Iran and all its neighboring countries between 1990 and 2015.
    Methods
    We extracted data from the GBD 2015 database. Observed YLL measures were calculated by multiplying the number of deaths by standard life expectancy at each age. SDI was a composite index, calculated based on income per capita, average years of schooling, and total fertility rate. The GBD world population was used for age standardization.
    Results
    All-ages crude death rate in Iran reduced from 665.6 per 100,000 population (95% uncertainty interval: 599.3–731.6) in 1990 to 487.2 (414.9–566.1) in 2015. The ratio of observed to expected YLL (O/E ratio) for all-causes ranged between 0.54 (Turkey) and 1.95 (Russia) in 2015. For Iran, the all-causes O/E ratio was less than 1 in all years (19902015), except 2003. However, cause-specific O/E ratio was more than 1 for some causes, including the top leading causes of YLL (ischemic heart disease, road injuries, and cerebrovascular disorders). Ischemic heart disease was the first or second cause of YLL in all comparator countries except Afghanistan.
    Conclusion
    The leading YLL causes with high O/E ratios should be prioritized in public health efforts. In addition to research evidence, countries with low O/E ratios should be scrutinized to find feasible innovative interventions.
  • Chante Karimkhani*, Robert P. Dellavalle, Seyed M. Karimi, Vafa Rahimi-Movaghar, Farshad Pourmalek, Aliasghar A. Kiadaliri, Mohammad Ali Sahraian, Gholamreza Roshandel Page 429
    Background
    Iran and its neighboring countries represent four world regions with unique cultures and geography. Skin diseases span a wide diversity of etiologies including infectious, inflammatory, autoimmune, vascular, neurogenic, and oncologic. The Global Burden of Disease Study (GBD) 2015 measures the burden from skin diseases in 195 countries.
    Methods
    Epidemiologic data were collected from literature review, survey data, and hospital inpatient/outpatient claims data. These raw data entered modeling using a Bayesian meta-regression tool, DisMod MR-2.1, which yielded prevalence estimates by age/sex/location/year. Prevalence estimates were combined with disability weights to yield years lived with disability (YLDs). YLDs are combined with years of life lost (YLLs), from mortality estimates, to yield disability-adjusted life years (DALYs). DALYs were obtained for 16 skin conditions and both sexes in Iran and 15 surrounding countries. The sociodemographic index (SDI) for each country was also correlated with skin disease DALY rate using the Pearson coefficient (r) with two-tailed p-value.
    Results
    There was no significant correlation between individual skin diseases and SDI. Acne and dermatitis caused the greatest burden and BCC the lowest burden of skin diseases in Iran and the other 15 countries. SCC and BCC were responsible for the largest discrepancy by sex, with higher burden in males compared to females.
    Conclusion
    Skin diseases, particularly dermatitis and acne, cause considerable burden in Iran and surrounding regions. Objective and transparent epidemiologic data such as GBD has the potential to inform and impact many facets of healthcare, research prioritization, public policy, and international partnerships.
    Keywords: DALYs, global burden of disease study (GBD), Iran, skin
  • Mehdi Zarean, Reza Shafiei*, Maryam Gholami, Abdolmajid Fata, Mansour Rahmati Balaghaleh, Ashraf Karimi, Farahnaz Tehranian, Ali Hasani, Arash Akhavan Page 441
    Objective
    The present investigation aims to evaluate the prevalence of IgM and IgG anti–T. gondii antibodies and the associated risk factors among healthy blood donors in Mashhad city, Razavi Khorasan province, Iran.
    Methods
    We screened a total of 500 serum samples by census method from apparently healthy blood donors of the Mashhad Blood Transfusion Organization (MBTO) for IgG and IgM anti–T. gondii antibodies by enzyme linked immunosorbent assay (ELISA).
    Results
    We found that 29.6%, 25%, 1.4%, and 3.2% of tested donors were positive for anti–T. gondii antibodies, only IgG antibody, both IgM and IgG, and IgM antibody alone, respectively. Several risk factors which were significantly related to T. gondii seropositivity in the univariate analysis at P
    Conclusions
    The results of this study can be a warning for blood transfusion organizations to pay special attention to toxoplasmosis among blood donors and also design screening programs for prevention of transfusion–transmitted toxoplasmosis.
    Keywords: Blood transfusion, IgG antibody, IgM antibody, Mashhad, prevalence, toxoplasmosis
  • Raheleh Sabet Sarvestani, Majid Najafi Kalyani, Fariba Alizadeh, Alireza Askari, Hossain Ronaghy, Ehsan Bahramali* Page 446
    Background
    Family physicians play an essential role and act as a communicational bridge between people and the healthcare system in providing healthcare services efficiently and equitably. This study aimed at exploring the challenges of the family physician program in urban areas in Iran in 2015.
    Methods
    This research had a descriptive exploratory design with a qualitative content analysis approach. Data were collected through semi-structured interviews between 2014 and 2015. Seventeen physicians enrolling in family physician program for at least two years were selected through purposeful sampling. Conventional content analysis was used to analyze the data.
    FINDING: Coding and analysis of the interview data generated two categories and seven subcategories related to the challenges of the family physician program. The categories were poor infrastructure and poor incentive mechanism.
    Conclusion
    Our findings captured a good picture of family physician program in urban areas to better clarify the challenges of the program and provide a foundation to plan and implement appropriate changes. Thus, our findings will give policymakers a deeper perception to confront the challenges of the family physician program in urban areas.
    Keywords: Family physician, health service, urban areas
  • Mehrdad Bakhshayesh Karam, Abtin Doroudinia*, Ali Safavi Nainee, Fatemeh Kaghazchi, Abbas Yousefi Koma, Payam Mehrian, Farahnaz Agha Hosseini Page 452
    Introduction
    PET/CT scan has an emerging role in head and neck oncology with a few well-established indications, including: detection of unknown primary tumor site, tumor staging, radiotherapy planning, treatment response assessment and detection of recurrent disease. The purpose of this study is reporting PET/CT findings in head and neck cancer patients to emphasize its role in head and neck oncology.
    Materials And Methods
    In a retrospective study, we reviewed our PET/CT database and found 94 patients with primary head and neck cancer. This is a descriptive report of PET/CT scan findings in head and neck cancer patients referred to Masih Daneshvari hospital, Tehran, Iran between 2013 and 2016.
    Results
    The most common primary tumor sites were oral cavity (27%) and nasopharynx (22%). The most common indication for referral was tumor restaging (76%) including treatment response evaluation and differentiation between recurrence and post-treatment fibrosis. In 60% of patients with negative primary tumor site, PET/CT was able to detect evidence of regional or distant metastasis. PET/CT was able to localize the primary tumor site in 66% of patients with unknown primary tumor site. We also had 19 patients with primary head and neck cancer referred for initial staging, demonstrating evidence of metastasis in 66% of all cases.
    Conclusion
    Most patients are referred for restaging and demonstrate evidence of regional or distant metastasis with significant value for further treatment planning. Providing insurance coverage and familiarizing referring physicians about correctindications of this relatively new diagnostic modality will be to the best interest of head and neck cancer patients in the long run.
    Keywords: Head, neck cancers, PET, CT, re, staging, staging
  • Modjtaba Raoufi Pharm, Hamed Abedtash Pharm, Abdolali Mohagheghzadeh Pharm* Page 461
    The pivotal role of plaster of Paris (POP) cast as an immobilization tool to promote healing in complex and/or other types of fractures is irrefutable. We clearly know that Antonius Mathysen extensively applied plaster cast during Crimea and/or other wars and reportedly saved thousands of lives. However, the exact origin of using POP in orthopedic cast is yet to be clear. In his famous report from Bandar-e Rig, a city in Iran, William Eton paved the way for the conclusion that POP cast might have originated from the Persian Empire. In this paper, we provide more supporting evidences which make the aforementioned claim more probable.
    Archives of Iranian Medicine,Vol. 20, No. 07, July 2017, -
    Keywords: Persian Empire, plaster of Paris cast, William Eton