فهرست مطالب

Catalysis - Volume:6 Issue: 4, Summer 2016

Iranian Journal of Catalysis
Volume:6 Issue: 4, Summer 2016

  • تاریخ انتشار: 1395/07/05
  • تعداد عناوین: 12
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  • Deepak S. Kawade, Mahendra A. Chaudhari, Jitendra B. Gujar, Murlidhar S. Shingare* Pages 313-318
    Herein we explore facile synthesis of 4-(3H)-Qunazolinone derivatives, achieved by the cyclocondensation of anthranilic acid, aromatic amines and triethyl orthoformate in presence of thiamine hydrochloride (Vitamin B1) as a catalyst, using grinding method. This protocol offers several advantages such as reusability of catalyst, excellent yield, shorter reaction time and economic availability.Quinazolinone derivatives are one of the most important class of biodynamic heterocycles due to their wide range of biological activities such as anticancer [1], antitubercular agent [2], anti-inflammatory and antioxidant [3], anticonvusant agent [4], antimicrobial [5], antitumor [6], ACHE inhibitor [7], antiviral [8] and calcilytic activities [9-10]. Owing to the broad range of pharmacological, biological activities and development of new method for synthesis of quinazolinones derivative is still desirable.
    Keywords: Anthranilic acid, Multi, component reaction, 4, (3H), Quinazolinones, Thiamine hydrochloride (VB1)
  • Javad Safaei, Ghomi *, Mehrnoosh Asgari, Kheirabadi, Hossein Shahbazi, Alvi, Abolfazl Ziarati Pages 319-324
    Nanocrystalline ZnZr4(PO4)6 ceramics as an efficient catalyst have been used for the preparation of methyl 6-amino-5-cyano-4-aryl-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates by the four component reaction of dimethylacetylenedicarboxylate, hydrazinehydrate, malononitrile and aromatic aldehydes in water at room temperature. In this research Nano-ZnZr4(PO4)6 coordinate with the active groups(particular C=O, C≡N and active H) thus increasing the activity of the groups. Also this nanoscale heterogeneous catalysts present higher surface areas which are mainly responsible for their catalytic activity. These surface atoms behave as the centers where the chemical reactions could be catalytically activated. The key advantages of this process are high yields, shorter reaction times, reusability of catalyst, easy work-up, milder reaction conditions and environmentally benign.
    Keywords: Nano, ZnZr4(PO4)6, Catalytic activity, Pyrano[2, 3, c]pyrazole, One, pot, Multicomponent reaction
  • Mohammad Bakherad*, Ali Keivanloo, Amir Hossein Amin, Raheleh Doosti, Ommolbanin Hoseini Pages 325-332
    In this report, the synthesis, characterization, and application of the eggshell-supported-Cu(II) salophen complex, as a novel and heterogeneous catalyst, is described. The catalyst is characterized by the UV, XRD, FT-IR, and SEM techniques. The eggshell-supported-Cu(II) salophen complex is a versatile, green, inexpensive, and simple catalyst used for the multi-component reactions (MCRs) of terminal alkynes, aldehydes, and secondary amines to give the corresponding propargylamines at 80 °C under the solvent-free conditions. The proposed methodology offers several advantages such as excellent product yield, simple procedure, and mild conditions. On the other hand, the synthesized catalyst could be removed from the reaction mixture by simple filtration, and reused for up to six runs.
    Keywords: Eggshell, supported, Cu(II) catalyst, Aldehyde, Amine, Alkyne, Propargylamine
  • Firoz A. Kalam Khan, Amol M. Pachpinde, Mallinath M. Langade, Kishan S. Lohar, Sunil M. Patange, Omprakash G. Bhusnure, Jaiprakash N. Sangshetti* Pages 333-338
    A facile and highly efficient one-pot synthesis of multisubstituted pyrrole derivatives is reported via a four-component reaction of amines, aldehydes, acetylacetone and nitromethane using Pr3 doped CoFe2O4 as a catalyst in solvent free conditions at 90°C. The catalyst is easily recoverable using magnet and could be reused without a significant loss of catalytic activity. Even after five runs for the reaction, the catalytic activity of Pr3 doped CoFe2O4 was almost the same as that of the freshly used catalyst. The proposed method is advantageous due to its little catalyst loading, short reaction time, catalyst reusability, and excellent yields.
    Keywords: Pr3+ doped CoFe2O4, Multisubstituted pyrroles, Recoverable using magnet, Catalyst reusability
  • Razieh Talaei, Abolfazl Olyaei* Pages 339-343
    A facile and highly efficient protocol was applied successfully to synthesize 4H-pyrimido[2,1,b]benzimiazoles and 4H-pyrimido[2,1,b]benzothiazoles through one-pot three-component cyclocondensation reactions of 2-aminobenzimidazole or 2-aminobenzothiazole with dimedone and aromatic aldehydes in the presence of guanidinium chloride under solvent-free conditions. The reactions using guanidinium chloride provided high to excellent yields of the products. The key advantages of this process are operational simplicity, inexpensive catalyst, short reaction time, simple workup and non-chromatographic purification, which make it an attractive route for the synthesis of benzimidazolo/benzothiazolo quinazolinones. Due to these advantages, several benzimidazolo/benzothiazolo quinazolinones as important pharmaceutical molecules can be prepared in high yield and high purity.
    Keywords: Aldehydes, Guanidinium chloride, Solvent, free, Benzimidazoloquinazolinone, Benzothiazoloquinazolinone
  • Mehdi Zamani *, Hossein A. Dabbagh Pages 345-353
    In this study, the dissociative adsorption of NaNO2, NaNO3, HNO2, HNO3 and H2SO4 over (1 1 0) surface of γ-alumina non-spinel model were investigated through the dispersion corrected density functional theory (DFT-D) at PBE-D/DNP level of calculation. It was found that all of the species are dissociated to their ionic forms after adsorption and relaxation over the surface, i.e. Na㓭−, Na㓭−, H㓭−, H㓭−, Hᴣ− and 2H䣮−. The Lewis acidity of alumina surface by addition of HNO2, HNO3 and H2SO4 is increased, while in the presence of NaNO2 and NaNO3, the acidity of catalyst is decreased. Theoretical calculations predict stronger dissociative adsorption of H2SO4 over the surface in compared to other compounds. The HNO2 and HNO3 mineral acids are better adsorbed over the surface than NaNO2 and NaNO3 salts. The better adsorption of nitrites than nitrates is due to the stronger electrostatic attractions. The order of NaNO3
    Keywords: ? Alumina, Surface, Adsorption, Dissociation, DFT, DOS
  • Ganesh T. Pawar, Rameshwar R. Magar, Machhindra K. Lande* Pages 355-362
    Natural mesolite type zeolite was collected, modified by sulfuric acid treatment and characterized by using Powder-X ray diffraction (XRD), Scanning electron microscopy (SEM), Energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FT-IR).Temperature programmed ammonia desorption (NH3-TPD), Brunauer-Emmer-Teller (BET) surface area analysis. Modified dealuminated mesolite shows an efficient catalytic activity for the one-pot synthesis of quinoline-3-carbonitrile derivatives, via three-component cyclocondensation of benzaldehyde, malononitrile and aniline. The present method offers several advantages over the reported methods like simple and inexpensive modification of the catalyst, mild reaction conditions and easy separation of the catalyst, simple work-up procedures, non-chromatographic separation and purification of desired product, excellent yield and reusability of the catalyst.
    Keywords: Modification of natural zeolite, Mesolite, Quinoline, 3, carbonitile, Aniline, Malononitrile, Benzaldehyde
  • Mahshid Hossaini, Reza Heydari*, Malek Taher Maghsoodlou Pages 363-368
    In this work, an eco-friendly procedure for the preparation of 2,3-dihydroquinazoline-4(1H)-ones was developed by condensation reaction of benzylic and heterocyclic aldehydes with 2-aminobenzamide in the presence of catalytic amounts of cyanuric chloride (2,4,6-trichloro-1,3,5-triazin) as an available and inexpensive organo-catalyst under aqueous media as a green conditions. The new compounds characterized by IR, 1HNMR, 13CNMR, Mass spectrometry, and CHN elemental analysis. Excellent yield, clean reaction media, simple workup and easy purification are advantages of this methodology.
    Keywords: Cyanuric chloride, Organo, catalyst, Quinazoline, Green Chemistry, Aldehyde, Water
  • Ghodsi Mohammadi Ziarani *, Mahshid Rahimifard, Alireza Badiei, Ali Abolhasani Soorki Pages 369-375
    Mesoporous silica LUS-1 (Laval University Silica) was successfully functionalized by propyl sulfonic acid and was used as a recyclable catalyst for the synthesis of acridine-1,8-diones via a pseudo four component reaction of aromatic aldehydes, dimedone and ammonium acetate (or anilines). The excellent yields, short reaction time, simple work-up procedure, and environmentally friendly conditions are advantages of this method. All synthesized compounds were screened for antimicrobial and antifungal activities. Only compound 3e exhibited activity against Bacillus subtilis.
    Keywords: Sulfonic acid functionalized LUS, 1, Acridine, 1, 8, dione, Dimedone, Nanoporous acid catalyst
  • Mohammad Ali Bodaghifard*, Najmieh Ahadi Pages 377-380
    Mild and applicable synthesis of mono-, bis-, and spiro- perimidines is demonstrated in high yields via the condensation of 1,8-diaminonaphthalene and aldehydes or ketones in the presence of sulfamic acid as a green and highly efficient catalyst. This environmentally benign and clean synthetic pathway offers several advantages, such as high yields, short reaction times and easy work-up procedure.
    Keywords: Sulfamic acid, Perimidine, Spiroperimidine, Catalyst, green synthesis
  • Masoud Giahi *, Akram Hoseinpour Dargahi Pages 381-387
    ZnO and SnO2-doped ZnO nanoparticles were prepared by a sol–gel method for the first time. X-ray diffraction (XRD) and scanning electron microscopy (SEM) were used to characterize the ZnO and SnO2-doped ZnO samples. Advanced oxidation processes (AOPs) have proved very effective in treatment of the various hazardous organic pollutants such as surfactants and pharmaceuticals in water. The photocatalytic degradation of drug phenylephrine hydrochloride (PHE) was studied as model organic pollutant. Under UV exposure the process was investigated with ZnO and SnO2-doped ZnO. The degradation was studied under different conditions including irradiation time, pH, catalyst concentration, phenylephrine hydrochloride concentration and potassium peroxydisulfate as an oxidant. The experimental results indicated that maximum degradation (99.4±1.0%) of drug occurred with SnO2-doped ZnO catalyst. The results demonstrated that photodegradation efficiency of SnO2-doped ZnO was significantly higher than that of undoped ZnO.
    Keywords: SnO2, doped ZnO, Phenylephrine hydrochloride, Potassium peroxydisulfate, Photocatalytic degradation
  • Rajesh Kumar Singh*, Ketki Sahore, Rekha Rana, Sahil Kumar, Deo Nandan Prasad Pages 389-408
    1,4-Dihydropyridines (1,4-DHPs) are recognized as one of the most versatile pharmacophores present as central core in many pharmaceuticals. Low yield and harsh reaction conditions prompted the researchers for the development of new environmental- friendly methods for the synthesis of 1,4-DHPs. This review explored the development of various green chemistry approaches using new catalysts developed for constructing novel 1,4-dihydropyridine and its derivatives. The present review also encompasses the synthesis of some novel 1, 4-DHPs derivatives with novel pharmacological actions. We have restricted our review of synthesis and pharmacological actions of 1,4-DHPs from 2006 onwards.
    Keywords: 1, 4, Dihydropyridines, Green Chemistry, Pharmacological actions, Synthesis