Effect of HEMADO on the changes of nitric oxide and coronary flow in isolated hearts of male rats
Author(s):
Abstract:
Methods
21 male Wistar rats (250-300g) divided to four groups, each has seven members (n=7) as follow: without ischemia, control (ischemia without drug), drug (ischemia with drug), and ischemia with ethanol. The animals are anesthetized by Ketamine and Xylazine. The hearts were immediately taken and put on Longendorff apparatus and perfused by Krebs-Henseleit solution under constant pressure and temperature of 37 ºC. After 20 minutes of stabilization, Ischemic groups are also received 40 minutes of global ischemia and 90 minutes of reperfusion. In drug group, the hearts were perfused 25 minutes with Hemado enriched Krebs-Henseleit before the Ischemia. Result
HEMADO significantly enhanced of Nitric Oxide (P <0 / 05), in the drug group compared to the control group but it had no effect on coronary flow. Conclusion
Current study indicated that Hemado could keep the heart against ischemia-reperfusion injury. And it is found that increasing the of Nitric Oxide is responsible for the part of cardioprotective effect of Hemado.Keywords:
ischemia , reperfusion , isolated heart , Hemado , Rat , nitric oxide
Language:
Persian
Published:
Pharmaceutical Sciences, Volume:17 Issue: 4, 2012
Page:
267
magiran.com/p1009076
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!