Investigation of Radioiodination of Meta-Iodobenzylguanidine Compound with 131I Isotope in Solid Phase Using Cu Catalyser

In this study the radioiodination process of meta-iodobenzylguanidine with 131I isotope in presence of ammonium sulphate and Cu(II) Catalyser was investigaded. In order to optimize the process, the influence of different parameters on labeling yield was studied. The results of experiments showed that the use of oil bath with temperature of 160˚C is necessary. After the labeling process, purification step of the final product was carried out using Dowex-1x8 resin. The mean labeling yield was 97.2%. In this method radiolabelling of MIBG with 131I (185 MBq for diagnostic dose and 3330 MBq for therapeutic dose) is quite simple and it complies with the requirements of routine production of 131I-MIBG radiopharmaceutical for diagnostic and therapeutic purposes. This paper is a narration of industrial scale production of 131I-MIBG radiopharmaceutical.