Beta Lactamases and Extended Spectrum Beta Lactamases Producing Klebsiella pneumonia in Kermanshah

Klebsiella pneumonia is an opportunistic pathogen belongs to family of Enterobacteriaceae. This species, like most other pathogenic and opportunistic bacteria, is resistant to many classes of antibiotics. Regarding to prompt appearance and spreading of Beta lactamases and Extended Spectrum Beta Lactamase (ESBL) producing strains, Klebsiella is becoming resistant to most members of Penam and Cephem family of antibiotics. The aim of this study was determination of Beta lactamases and ESBL producing K. pneumonia isolated in Kermanshah.

Following identification of isolates using biochemical tests, existence of Beta lactamases and ESBL among the strains were detected using acidometry and Double Disk Diffusion method, respectively.

From 260 isolates, 247 were confirmed as Klebsiella pneumonia. Among those, 178 (72%) containing Beta lactamase and 111 (45%) possessed ESBL.

Our results showed the importance of Betalactamase and ESBL enzymes among Klebsiella pneumonia in Kermanshah, and the importance of precision and attention to antibiotic prescription.