Effects of regular aerobic exercise on cardiorespiratory fitness and levels of fibrinogen, fibrin D-dimer and uric acid in healthy and inactive middle aged men

The aim of this study was to investigate the effects of three months regular aerobic exercises on the levels of fibrinogen, fibrin D-dimer, uric acid, white blood cells count (WBC), red blood cell distribution width (RDW), body mass index (BMI) and cardiorespiratory fitness in middle aged healthy and inactive men. To implementation of this semi-experimental research, from employees in Ferdowsi university, 21 middle aged men with available method were selected and assigned into experimental (N=11, age: 44.7±4.3 y, height: 1.73±0.04 m, weight: 81.8±9.36 kg) and control (N=10, age: 41.2±8 y, height: 1.73±0.07 m, weight: 78.2±14.8 kg) groups. The experimental group performed an aerobic exercise protocol with the intensity of 75% to 85% of their maximum heart rate for three months (three days a week). Before and after trainings, aerobic power, body composition variables and fasting levels of blood variables were measured. Data analysis showed a significant elevation of RDW, aerobic power and WBC and significant reduction of BMI and uric acid in experimental group (P<0.05), but no significant change was observed in the levels of fibrinogen and fibrin D-dimer. Considering reduction of some inflammatory atherosclerosis risk factors, aerobic exercise may be recommended for improvement of cardiovascular health in middle aged men.