The effect of endurance training on lipid profile and expression level of Liver X Receptor α Gene in Male Wistar Rats

Liver X Receptors (LXRs) belong to the ligand activated transcription factors of nuclear hormonal superreceptors family which regulate the expression of involved genes in cholesterol homeostasis and act as sterol (cholesterols) sensors which they prevent the cellular cholesterol overload.Activation of LXRslead to themodulation of respective genes expression.To examine the effect of endurance training on lipid profile expression level of LXRα gene, twelve male wistar rats were divided into control (n=6) and Training (n=6) groups. Training group were received exercise on a motor-driven treadmill at 28 m/min (0% grade) for 60 min/day, 5 days/week for 8 weeks. Twenty-four hours after the last exercise session (eighth week), the rats were anesthetized intraperitoneally with a mixture ketamine and xylazine. The mount of blood was taken from the right ventricle of each rat and immediately a part liver were excised and for extraction of LXR RNA Then the frozen tissue was put into -80 °C freezer for mRNA condensation. All variables were compared by independent T-test. Date conducted significant increase in LXR gene expression (70%) and HDL-c (P=0.001) and also the significant decrease in LDL-c, TG, and TC (P=0.001) compared with those in the control group. It could be concluded that, it a positive mechanism of regular endurance exercise causes an improvement in lipid profile (increase in HDL) modulation of there by causes prevention of the cardiovascular diseases, through an increase in the LXR gene expression which resulted in depletion of the cellular cholesterol.