Short-time Outcome Predictors of Bipolar Disorder Type I in Children and Adolescents

This study aimed to evaluate the three and six month clinical and demographic outcome predictors (recurrence rate، the rate of hospitalization، severity of illness and recovery rates) in a group of children and adolescents with type I bipolar disorders. The participants of this longitudinal and prospective study were 80 children and adolescents admitted in Roozbeh Hospital، Tehran، Iran with a diagnosis of type I bipolar disorder. Consecutive referrals were included in a prospective cohort. The participants were evaluated at admission، discharge، and follow-up at 3 and 6 months، using demographic questionnaire، Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version-Persian Version (K-SADS-PL-PV)، Young Mania Rating Scale (Y-MRS)، Children Depression Inventory (CDI)، Beck Depression Inventory (BDI)، and Clinical Global Impression (CGI). The Pearson correlation coefficient and multivariate regressions were used for data analysis. The 6-month follow-up showed that there was a positive correlation between the severity of mania with male gender (p=0. 01) and the severity of mania at admission (p=0. 04). The rate of recurrence at the 6-month follow-up was correlated (p=0. 05، r=0. 22) with psychosis at admission. The duration of untreated disorder (p=0. 03) had a positive correlation with the severity of global impairment at the 6 month follow-up. This study confirms the role of some demographic and clinical features in predicting the course of disease and response to treatment.