Study of association between T/C single nucleotide polymorphism in CYP1A1 gene and cancer initiation and smoking status in lung cancer patients

Several single nucleotide polymorphisms have been found in CYP1A1 gene and it was reported that C allele in T/C gene polymorphism is associated with lung cancer. Current study investigates interaction between cigarette factor and C/T polymorphism in the m1 locus. Present study is a case-control and retrospective study. T/C polymorphism in 112 patients with lung cancer and 120 healthy controls was genotyped using RFLP-PCR technique. Association of the polymorphism and initiation of cancer including cigarette risk factor was analyzed statistically. , Association was seen between patient and control groups in the distribution of gene polymorphism (P<0.0001). No significant difference was seen in distribution of gene polymorphism between the two patient groups (smokers and non-smokers) (P=0.098). Results of present study show individuals with C allele are susceptible to lung cancer independent of cigarette smoking factor in Isfahan population. However determining the role of C allele as a biological risk factor needs more investigation.