Oxymetholone Induced Complications, on Testosterone, LH and FSH Hormone Levels among Male Rat Progeny Whose Mothers were Treated by Oxymethalone During Pregnancy and Lactation

Oxymetholone is an active nutritional anabolic steroid – androgenic which can result in some abnormalities such as lung cancer, ovarian cycle irregularity and liver cancer. The aim of this study is to investigate oxymetholone induced complications in levels of testosterone, LH, FSH hormones in mature progeny male rats, whose mothers were treated by oxymetholone during different pregnancy and lactation periods. In this study we used fifty six female rats and fourteen male rats aged 110-120 days, weighing were approximately 200±20g. The animals were divided into groups including control, solvent 1 (pregnancy- 21 days), solvent 2 (pregnancy- lactation- 42days) solvent 3 (lactation – 21 days), experimental 1 (pregnancy 21 days) experimental 2 (pregnancy- lactation- 42 days), and experimental 3 (lactation-21 days). Solvent groups used DMSO with 99.5% concentration and experimental groups used oxymetholone with 10 mg/kg concentration by intra peritoneum method. Hormone concentrations were measured by the radio immunoassay method. The rate of LH indicated significant decrease in experimental groups of pregnancy-lactation and lactation. FSH levels in the experimental groups of pregnancy-lactation and lactation and also testosterone in the experimental groups of pregnancy-lactation decreased compared to the control group. Oxymetholone in these doses most probably results in decreased LH, FSH and testosterone concentrations, leading to disturbances in the reproductive system of wistar.