Effect of hydroalcoholic extract of Anethum graveolens leaves on time response to pain stimuli in mice

Pain is the most common clinical complaints of the patients. Due to multiple and complex mechanisms of causing pain، finding new ways to overcome the pain is one of the biggest concerns of scientists. Because of applications of Anethum graveolens in traditional medicine، the effect of hydroalcoholic extract of Anethum graveolens on response time to pain stimuli in mice was studied. In this experimental study، 84 mice were divided into 3 categories. Each category contained a negative control (saline)، a positive control (morphine)، and two case groups of 200 ml/kg and 500 ml/kg extract of Anethum graveolens. Delay reaction was evaluated in groups 1، 2، and 3 in 15، 30 and 60 minutes after injection، respectively. The data were analyzed using one-way ANOVA and Tukey tests. This study showed that 15 minutes after injection، between saline group and the group that received the extract، significant difference was observed in duration of analgesia (P<0. 05). 30 minutes after injection، just the group that received 500ml/kg extract، showed a significant difference in duration of analgesia compared with saline group (P<0. 05). 60 minutes after injection، between saline group and the group that received the extract، no significant difference was observed in duration of analgesia (P>0. 05). Based on the results of this study، it can be concluded that extract of Anethum graveolens has a short analgesic effect. So، more research in this regard is recommended