The Effect of Scrophularia striata Extracts on Wound Healing of Mice

Scrophularia striata extract has been traditionally used for wound healing. The aim of this study was to evaluate the effect of Scrophularia striata extract on wound healing on mice. In this experimental study، a number of 35 male mice (NMRI) weighing 25-30 g were divided into 5 equal groups. Two 6 mm circular wounds were punched on the back of the mice; moreover they were treated for 3 weeks in separate cages. The first group wasconsidered as the control group and the other groups were treated with phenytoin ointment 1%، alcoholic extract، hydroalcoholic and aqueous 10% twice a day for 21 days respectively. The wounds were daily photographed by a digital camera and the wound area was calculated using Image J software. Data were analysed by Kruskal-Wallis and Mann-Whitney test. The average healing duration in the control group، phenytoin and extracts، aqueous and alcoholic were 9. 1 ± 3 6، 6. 6± 1. 9، 6. 5 ± 1. 7، 6. 7 ± 1. 8 and 6. 1 ± 0. 9 days respectively. The remaining scar size in these groups were 9. 08 ± 1. 83، 5. 84 ± 1. 20، 3. 7 ± 0. 62، 3. 5 ± 0. 74 and 2. 81 ± 0. 79 millimeters respectively. The average duration of scar healing and the remaining treatment groups were significantly different from controls (p<0. 05). Scrophularia striata extract decreased the period of wound healing in mice. Among the three types of extracts، the hydroalcoholic extract demonstrated the best result.