Effect of mucilage extracted from the fruit of Hibiscus esculentus on preventive of increasing glucose and lipid profile of diabetic rats by streptozotocin

Diabetes is an abnormality in metabolism which occurs because of hyperglycemia resulting from failure in insulin release, function, or both. This study aims to examine the effects of the mucilage extracted from pods of Hibscus esculentus fruits on prevention from increase in fasting glucose and lipid profile in serum of the rats made diabetic by stretozotocin. In this experimental study, 30 male wistar rats were enrolled. The rats were divided into three 10-member groups: healthy control, diabetic control, and mucilage-treated case. After preparing and confirming the type of H. esculentus, mucilage extraction from the fruit’s green okra was done by evaporation device in vacuum. The mucilage-treated group rats received 2 g/kgbw of the mucilage extracted from H.esculentus daily for two weeks and were made diabetic by intraperitoneal injection of streptozocin in 60 mg/kgbw dose. After confirming diabetes, the animals received the same amount of mucilage daily for three weeks through gavages. Prior to diabetes induction and at the end of the experiment, blood collection was done from all animals and the factors of interest were examined. The data analyzed by SPSS software using Wilcox on, Friedman, Kruskal-wallis, and ANOVA. A significantly higher increase in glucose, low-density lipoprotein, and triglyceride was observed in diabetic rats compared to the other two groups (P<0.05). Mucilage consumption also led to a significant decrease in glucose, cholesterol, high-density lipoprotein, and low-density lipoprotein in diabetic rats (P<0.05). The mucilage extracted from H. esculentus could be effective on prevention from hyperlipidemia and hyperglycemia caused by diabetes mellitus.