Evaluation of Troponin-T level in Neonate with Mechanical Ventilation

Troponin- T is the best biological marker of heart injuries، that isn’t affected by sex، age، birth weight and gestational age. Myocardial damage in infancy is a risk factor eventual cardiac disease. This study carried out for cardiac evaluation of neonates with mechanical ventilation by Troponin T. This case-control study carried out on 60 infants that were admitted in neonate intensive care unit of Amir Almomenin hospital، Zabol، Iran. Neonates were enrolled in 2 groups: those who were supported with ventilator as cases and those who were not supported with ventilator as control group. We assayed the serum samples from neonates for Troponin T for myocardial injury. Data was analyzed using Pearson correlation، Mann-Whitney and Chi-square tests by SPSS software and significance level of 0. 05. Troponin T levels in case group was significantly different than it in control group at the beginning of the study and 24 hours after that (P<0. 05). Generally، Troponin T level in case group was significantly higher than it in control group. We conclude that evaluation of newborn with mechanical ventilation enhances the possibility of occult and clinically myocardial injury. The results، in this study، suggest that Troponin T is a useful and early marker for myocardial injury.