Effect of Helicobacter Pylori Eradication on Clinical Symptoms in Gastroesophageal Reflux Disease

Backgrounds and Gastroesophageal reflux disease is one of the most prevalent gastrointestinal disorders and the relationship between GERD and H. pylori is complex and effect of H. pylori eradication on GERD is controversies. The aim of study is to evaluate the effect of H. pylori eradication on GERD symptoms. In an interventional، before-after study، of 200 patients with chronic dyspepsia and positive H. pylori infection confirmed by rapid urea test or histology and underwent a 2 weeks period of quadruple anti-Helicobacter therapy and a subsequent 6 weeks of pure anti-acid therapy. Eradication''s success was assessed based on urea breath test result at least 2 weeks after anti-acid cease، and the second validated symptom questionnaire then was filled out which contained the same questions as the first one. A validated symptom questionnaire about probable symptoms of GERD also filled. GERD''s symptoms (Regurgitation، Heart burn) were increased in the eradication group. (heart burn: 16% to 32% p=0. 03)، (regurgitation 13. 6% to 15% p=0. 04). Retrosternal pain was meaningfully decreased (36% to 29% p=0. 04). Wheeze (1. 4% to 0. 5% p=0. 03) and hoarseness (1. 5% to 0. 6 %p=0. 03) had meaningful decrease. H. pylori eradication has variable effect on GERD''s symptoms are infected individuals.