A survey of high-throughput technologies in the development of new therapeutic agents

Development of new therapeutic agents and exploring their mode of actions for the treatment and prevention of diseases has played a critical role in the practice of medicine for many years. Unfortunately، conventional approaches have yielded very few successes in the field of drug discovery. So، there is an urgent need to change the current drug discovery process that has high cost، low efficacy، and high adverse drug reactions. During the past few years، development of high-throughput technologies enables insight into the biological mechanism of action of drugs and the discovery of novel therapeutic applications. These methods are used in many drug discovery processes in order to reduce costs and shorten cycle times. In this review، we study current high-throughput technologies in drug discovery included chemical microarray، gene expression microarray and yeast chemical-genetic assays that have generated many successes in the evaluation of chemical–protein interactions، target identification and cell-based functional analysis and summarize the potential application of each approach.