Comparison of IVF Outcome in Two Groap of Patients with PCOS

PCOS (Polycystic ovary syndrome) patients undergoing infertility treatments present a greater sensitivity to gonadotrophins and higher incidence of OHSS when human chorionic gonadotropin (hCG) is administrated for the induction of final oocyte maturation. Lower dose of hCG can reduce the occurrence of OHSS The aim of present study was to evaluate the effect of hCG dose reduction on IVF outcome in PCOS undergoing controlled ovarian hyperstimulation In this retrospective study، we included 39 women with PCOS who had undergone one-third dose depot GnRH agonist protocol. Ovarian stimulation was initiated with rFSH and continued by HMG. Final follicular maturation is triggered by 5000 (group A) or 10000 IU (group B) of hCG according to antral follicle count and estradiol levels. Basal and stimulation variables were analyzed between the groups. There were no significant differences seen in all characteristics (Age، BMI، LH، FBS، cholesterol level، prolactin، Hirsutism، menstrual cycle، length of stimulation، E2 level on hCG day، number of total and MII oocytes، number of embryos transferred، mean transferred embryo score، OHSS، ongoing implantation rate، biochemical pregnancy rate، abortion rate، live birth rate) between the groups except for the number of GnRH ampoules. The E2 level and the number of total and metaphase II oocytes were higher in 5000 IU group. Higher rates of biochemical pregnancy، live birth and continuing pregnancy were observed in 10000 IU group. It seems that reduction in implantation rate and IVF outcome is related to lower dose of hCG in PCOS undergoing one-third dose depot GnRH agonist protocols.