The effect of 8 weeks low and high intensity aerobic exercise training on obestatin and cholecystokinin serum in obese male Spragu-dawly rats

Gastrointestinal hormones have been in the center of attention in recent decades. Obestatin is an anorexigenic gastrointestinal hormone. Cholecystokinin is the other hormonal regulator of the digestive process، that is anorexigenic. The purpose of this study is to investigate the probable changes in obestatin and cholecystokinin serum after 8 Weeks exercise with different intensities on Fat male rats. 75 adult male rats، aging about 2 month، were chosen randomly from a laboratory. The rats were fatten for a month. Their average weights changed from 225-255 to 300-340 geram. Then، they were divided into three groups of control، exercise with low intensity group and exercise with high intensity group. The training program of the study consisted of running on Rodents'' treadmill for 8 weeks. Blood sample were finally taken from the heart of the rats in order to measure obestatin and cholecystokinin serum. Descriptive statistics were used to evaluate mean and standard deviation; in order to study the meaningful difference between groups، one way analysis of variance test was utilized and Pearson correlation was used to determine the relationship between groups. The result showed that there was a meaningful difference in the average obestatin and cholecystokinin in control، exercise with high and exercise with low intensity. As opposed to exercise with high intensity group، there was a significant difference in the changes of obestatin and cholecystokinin in exercise with low intensity group. Finally، the present study illustrated that exercise activities leads to reduce these two hormones.