Antihyperglycemic and Antihyperlipidemic Effects of Daucuscarota ssp. sativum Seeds Extract in Diabetic Rats

With respect to efficacy and less adverse side effects of medicinal plants، interest in alternative therapeutic approaches for treatment of diseases has become very popular. So in this study antihyperglycemic and antihyperlipididemic properties of 14 day administration of methanolic extract of D. carota seeds were investigated in streptozotocin-induced diabetic male rats. In this experimental study، type I diabetes was induced in 30 male Wistar rats (200-250g) by injection of 65 mg/kg، i. p of streptozotocin. Before this and 5 days postinjection blood samples were collected for measurement of serum level of glucose. Diabetes was confirmed in rats having FBS above 250 mg/dL. Thirty diabetic rats were divided to 5 groups (six animal for each group) received 100، 200، 300 mg/kg of extract، 600 µg/kg glibenclamide and 0. 5 ml distilled water individually by gavage for 14 days. After 14 days rats sacrificed by decapitation and fasting blood samples were collected from cervical vein and above factors were measured with commercial kits by spectrophotometery. Administration of the methanol extract of D. carota seeds) 100mg/kg) for 14 days had no significant effect on serum glucose level but significantly decreased triglycerides (113±13 vs. 84±4، p<0. 05)، LDL (27±9 vs. 9±4، p<0. 01) and VLDL (22. 6±2 vs. 16. 8±0. 8، p<0. 05) and at 300 mg/kg decreased triglycerides (175±41 vs. 61±6، p<0. 01)، VLDL (35±8 vs. 12±1، p<0. 05)، cholesterol (95±4 vs. 72±6، p<0. 05)، LDL (30. 4±2 vs. 10±3، p<0. 05) and increased HDL (42±3 vs. 50± 4، p<0. 05) serum levels in comparison with diabetic groups. According to the results of this study، administration of Daucuscarota seeds extract for 14 days has mild antihyperglycemic but significant antihyperlipidemic effects in diabetic rats.