Poly(MAA-g-EG) Nanogels: Synthesis, Characterization and Evaluation as Drug Carrier for Naltrexone

In this paper, the synthesis and characterization of nanogels by the emulsion polymerization of methacrylic acid as monomer, polyethyleneglycol diacrylate (PEGDA) as macromonomer is described. The influence of various reaction parameters, such as monomer and comonomer molar feed ratios, cross-linking agent concentration, and drug concenteration on the entrapment efficiency of nanogels was investigated. Nanoparticles prepared under optimum condition showed high entrapment efficiency (up to 89%). The synthetic nanoparticles were characterized by dynamic light Scattering (DLS), fourier transform infrared spectroscopy (FT-IR), and differential scanning calorimetry (DSC). Particle size analysis exhibited that the particles size and PdI for nanogels were 324.7nm and 0.553, respectively. The time dependent drug release of incorporated and corresponding incubated nanogels was monitored by UV–visible spectroscopy for 18 days.