The effects of 8 weeks ofintervalcombinedexercise trainingon risk factorsof asthma, insulin resistanceand some of the major physiological indices in overweight and obese adolescents

Eotaxin، which is an important chemokine in asthma، was recently reported to be increased in obesity in mice and humans. The purpose of this study was to investigate the effect of exercise training on plasma eotaxin levels، insulin resistance، maximal oxygen consumption (Vo2max) and some of the major physiological factors in overweight and obese adolescents. In this experimental study، 28 healthy obese and overweight male adolescents were randomly selected. We divided the obese subjects into two groups: exercise group (N = 13) and control group (N=15). The exercise group performed combined exercise training، 4 days a week (70 min/d) for 8 weeks. Vo2max،adiposity، insulin resistance، lipid profile and eotaxin were measured before and after the completion of exercise training. Independent T-test and Pearson''s correlation coefficient were used for data analysis. p<0. 05 was considered significant. The results showed that 8 weeks of interval combined exercise training increased eotaxine level and Vo2max، and decreased insulin resistance، percentage of body fat، weight، BMI، WC، and plasma levels of triglycerides in obese male adolescents (P<0. 05). There was no significant relationship between primary level of eotaxine with other factors (P<0. 05). In spite of increased eotaxine level after 8 weeks of interval combined exercise training، We observed positive effects on some of the physiological indices (TG، %BF، insulin resistance، central obesity، BMI and Vo2max) in overweight and obese adolescents.