The Effect of Natural Compounds on Serum Total Antioxidant Levels in Mice Obese

Obesity is often associated with micronutrient deficiency, the result of poor diet, lack of antioxidants and polyunsaturated fat on one side and saturated fats, on the other side. Oxidative stress has a role in the onset of chronic diseases associated with obesity.Plant-derived secondary metabolites such as phenolics and total flavonoids may have potential for free radical scavenging. The purpose of this study was to determine the effect of natural compounds such as thymol, acarbose,thioflavin T and Chalcone on serum total antioxidant levels in mice obese. This study was performed in NMRI male mice. Animals were randomly divided into two groups: a control group (receiving standard rodent diet) and experimental group for 8 weeks (receiving high-calorie diet group).The obese animals into three groups: sham,obese and experimental groups. In the experimental group of mice with compounds thymol, acarbose, thioflavin T and Chalcone (12mg/kg/day) were gavage for 8 weeks. The end of treatment, blood samples, to investigate serum total antioxidant capacity (Total Antioxidant Capacity, TAC) was performed. Antioxidant capacity decreased in the obese group, the sham TAC levels than obese and control increased. In all treatment groups, TAC levels increased, but this increase in the thioflavin and chalcone group compared with the other groups was not significant; but in acarbose group (P<0.01) and thymol group (P<0.05) TAC levels were significantly increased. This study showed that natural compounds derived from plants such as thymol and acarbose can increase TAC levels in obese animals. Since that oxidative stress plays a pivotal role in the onset of chronic diseases associated with obesity, so we can used of these compounds for the treatment of obesity and increase of levels of antioxidants.