Evaluate the liver function in hyperthyroidism patients

Thyroid hormones regulate the metabolisms of all cells including hepatocytes, and hence, modulate hepatic function. Hyperthyroidism is one of the most common endocrine disorders characterized by increased secretion of thyroid hormones T3 and/or T4. This study investigated frequency of abnormal liver function tests in the patients with hyperthyroidism that referred to Imam Reza Hospital of Kermanshah from 1st October 2009 to 30th April 2012. Patients who had complication disorders such as cardiovascular disease, hypertension, diabetes mellitus, liver disease and using any of drugs effecting liver and thyroid function tests and patients with positive hepatic viral markers were excluded from the study. After excluding patients with complication disorders, fifty patients were remained. Fifty volunteers without history of significant diseases were chosen as matched control group. Mean ALT (Alanine amino transferase) of cases were 52.1±6.97 and of controls were 25.6±3.9. Also, Mean ALP (Alkaline phosphatase) of cases was 259.94±25.83 and of controls were 185.10±33.75. There is significant difference between ALT, ALP in case group in compare the control group (P<0.05and P<0.01 respectively). Further, there is no significant difference in serum levels of AST (Aspartate amino transferase) and Mean direct bilirubin between case and control group. These findings indicate that ALT and ALP levels are frequently elevated in hyperthyroidism. Hence, they are possibly thyroid dependent enzymes.