The effect of Teucrium Orientale on Oxidative Stress marker and Liver Function Enzymes in Streptozotocin-Induced Diabetic Rats

Diabetes is a chronic disease caused with decreased insulin secretion in beta-cell dysfunction of pancreatic or an increase in insulin resistance. The aim of this study was to investigate the effects of methanol extract of Teucrium orientale on blood glucose and liver damage markers in streptozotocin diabetic rats. In this experimental research 32 male albino Wistar rats, with body weights of 200–240g were randomly allocated into four groups of 8 rats in each. Groups included: control (normal rats), diabetic rats (received STZ in single dose 60 mg/kg bw, intraperitoneal way and without receive extract), treated normal rats (received T. orientale 200 mg/kg bw, oral gavage) and diabetic treated rats (received STZ in single dose 60 mg/kg bw, intraperitoneal way and received T. orientale 200 mg/kg bw, oral gavage). After 21 days, blood glucose, (MDA) in liver and the activity of the liver enzymes (ALT، AST،ALP (were evaluated. The collected data were analyzed using SPSS software via the one-way ANOVA. Resulths: This study demonstrated that serum levels of glucose in T. orientale treated diabetic group (222 ± 9. 8) were significantly lower than diabetic rats (572 ± 8) (P < 0. 01). The MDA level in T. orientale treated diabetic group (1. 01 ± 0. 04) was significantly decreased in comparison to diabetic rats (1. 25± 0. 54) (P < 0. 05). The ALT, AST and ALP levels in T. orientale treated diabetic group were significantly decreased compared to diabetic rats (P < 0. 01). The results of this study showed that methanol extract of T. orientale had antidiabetic effects and consequently might have alleviated the liver damage caused by streptozotocin-induced diabetes mellitus.