Comparison of pain on propofol injection with three methods: mixed lidocaine with Propofol, propofol after lidocaine injection and purified one percent propofol injection

Aims and Propofol is one of the newest and the most common drugs in anesthesia and intensive care unit which is used to produce sedative effects. One of its complications is the pain produced at the time of injection. The aim of this study is to compare the pain of Propofol injection with two techniques: Propofol mixed with lidocaine and Propofol injection after lidocaine. This study is a randomized double-blind clinical trial, in which 172 patients undergoing elective surgery with ASA class one and two were enrolled. Three groups of patients had injections as follows: In the first group 40 mg Propofol mixed with 2% lidocaine, in the second one purified one percent propofol, and in the third group Propofol following injection of 40 mg lidocaine 2%, were injected. Venous catheter 20 gauge was used in all cases for injection, and pain intensity was measured by VRS (Verbal Rating Scale) criteria. The data were analyzed by SPSS V.18. Pain intensity in the second group (Propofol injection after lidocaine injection) was less than the first group (mixed injection) and there was a statistically significant difference between the two groups (P<0.05). The hemodynamic changes were similar in both groups, and there was no significant difference (P>0. 05). Pre-treatment by injecting 40 mg of lidocaine2% to reduce pain due to Propofol injection is more effective than mixed method of injecting 40 mg of Propofol with lidocaine 2%.