The Effects of an Antiobesity Drug, Orlistat on the Liver and Testis of NMRI Male Mice

obesity is a global epidemic health problem, which is related to many diseases such as type 2 diabetes, cardiovascular disease and types of cancers which impose a huge burden on individuals and health care system and society, therefore different antiobesity strategies are developed that using antiobesity medicines is a very common method besides exercise, diet. since every drug has side effects on some organs it is required to know these side effects and their severities. Liver and testis are two metabolic and reproductive organs of body additionally orlistat ameliorates poly cystic ovary syndrome (PCOS) by decreasing androgen levels then the study of its effect on testosterone levels in obese men could be important because of probability men infertility. In current study, we examined the effect of orlistat on serum ALT, AST, ALP and testosterone levels also liver and testis tissues in uncomplicated obese NMRI mice during six weeks. We studied control, obese, sham and experimental groups. In this study all groups except control group after acclimatization for one week received H.F.D for six weeks, after that all groups were fed by standard laboratory chow diet. Sham group received P.B.S and Experimental group received solution of orlistat orally during six weeks. The body weight was measured during the study period weekly. Our results showed that enzymes levels increased in obese group compare with other groups then orlistat ameliorated enzyme levels in experimental group but it was no differences significantly (P>0.05).Testosterone levels indicated changes between groups but these changes were not statistically significant (p > 0.05).