Effects of Calendula officinalis Hydroalcoholic Extract on Blood sugar, LDL, HDL and Total cholesterol in Streptozotocin-induced Diabetic Adult male wistar Rats

It’s very important to decrease the glucose level and lipid’s serum in diabetes patients by using medicinal plants. In the present study, the effect of hydroalcoholic extract of Calendula officinalis on blood glucose, LDL, HDL and total cholesterol in diabetic rats was examined. In this experimental study, thirty adult male Wistar rats were randomly divided into control, diabetic and diabetic treated with hydroalcoholic extract of Calendula officinalis (100, 150 and 250 mg/kg) groups. Diabetes was induced by streptozotocin. Injections were intraperitoneally (I.P). After thirty days, the blood glucose, total cholesterol, HDL, LDL was measured and the data were analyzed with One-way ANOVA. The results showed that blood sugar(glucose) significantly reduced in treated diabetic groups with extract as compared to untreated diabetic group (150 & 250 mg/kg) (p<0.05).. Also LDL and Total cholesterol in the group treated with the extract decreased significantly compared to the diabetic control group (p<0.05). This study indicated that the hydroalcoholic extract of Calendula officinalis had a hypoglycemic effect and led to appropriate changes on blood lipid profiles levels in diabetic rats.