Retinal Biocompatibility of Brilliant Blue G with Deuterated Water for Chromovitrectomy

Author(s):

Emmerson Badar , Oacute , Milton Moraes , Filho , Mauricio Maia , Fernando M. Penha , Eduardo Amorim Novais , Rodrigo A. Souza , Lima , Flavio Hirai , Carsten H. Meyer , Michel Eid Farah , Eduardo B. Rodrigues

Message:
Abstract:
Purpose
To investigate the retinal biocompatibility of Brilliant Blue G with deuterated water (BBG-D2O) as a vital dye for chromovitrectomy.
Methods
In this animal study, 0.05 mL of 0.25 g/L Brilliant Blue G (BBG) associated with 0.13 mL/mL of deuterium oxide (D2O) was injected intravitreally in the right eye and the same amount of balanced salt solution (BSS) was injected similarly in the left eye of rabbits. Clinical examination and histology with light microscopy were performed after seven days. Retinal cell layers were evaluated for morphologic alterations. Electroretinographic (ERG) changes were also assessed at baseline and 7 days after the injections.
Results
A total of 6 rabbits were included in the study. The gross histopathologic appearance of the retina, choroid, sclera and optic nerve was within normal limits without any sign of severe retinal necrosis or cystic degeneration. Light microscopy showed that BBG-D2O caused no substantial alterations in retinal layers as compared to control eyes. The injection of BBG-D2O did not induce considerable functional ERG alterations.
Conclusion
Intravitreal injection of BBG-D2O 0.25 g/L seems to induce no retinal toxicity as documented by lack of functional and histological changes.
Language:
English
Published:
Journal of Ophthalmic and Vision Research, Volume:9 Issue: 2, Apr-Jun 2014
Pages:
204 to 209
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