The effect of oral and central administration of AlCl3 on move-ment and coordination in adult male rat

One of the most abundant metal in the earth crust is Aluminum. Different sources of this metal can have a great affect on humans body. Food, water, compounds of medicine and environment are main sources of Aluminum. It also could be found in the soil and that’s because of acid rain. Increasing the amount of Aluminum in our body could caused disorders like Dementia (lesion of the brain) in Alzheimer and movement disorder in Parkinson in both human and animals. Its not completely proved that Aluminum plays the main role in these disorders. Because of the most significant role of Aluminum in neurofibers toxicity, it seems that Aluminum is the main cause of movement and coordination disorders in Parkinson. In this research, the effect of oral and central administration of AlCl3 on movement and coordination in adult male NMRI rats has been observed with Rota-Rod Apparatus. Observing motor resistance and coordination was the main purpose of this test. Achievements of these tests have showed that oral and central administration of AlCl3 decreased coordination and balance movement in rats. Aluminum is sort of selected neurotoxin and as a toxic, it compounds to natural peptides which are existed in the brain. Controlling the nerve system enzymes, Aluminum decreases brain cells energy, tiredness and developing disabilities. Central nervous system disorder which caused by Aluminum compounds, finally ends to a developing encephalopathy.