Administration of Salvianolic Acid B Attenuates Learning and Memory Deficits in Diabetic Rats: Involvement of Oxidative Stress

Based on the effect of chronic metabolic diseases including diabetes mellitus on the learning and memory, this study was designed to assess the usefulness of administration of salvialonic acid B on lessening of learning and memory deficits in streptozotocin (STZ)-diabetic rats. Male Wistar rats were allocated into control, salvialonic acid B-treated control, diabetic and salvialonic acid B-treated diabetic groups. Salvialonic acid B was administered at a dose of 10 mg/kg/day for 8 weeks. Assessment of learning and memory was performed by Y maze and passive avoidance tests. Moreover, oxidative stress marker malondialdehyde (MDA) was also measured. The results showed that in diabetic rats, alternation score in Y maze and retention and recall in passive avoidance test decreased in comparison with control rats (p) Taken together, these results show that salvialonic acid B could improve learning and memory deficits in STZ-diabetic rats by reduction of lipid peroxidation.