Lactate Transporters Expression in Tumor of Balb/c Mice Bearing Breast Cancer after Endurance Training

Changes in the metabolism of cancer cells plays a major role in the survival and their expansion. The aim of this study was to determine expression of lactate transmitters in Balb/c mice with breast cancer after endurance training. In this experimental study twenty-five Balb C mice were randomly divided into two groups of breast cancer control (N=13) and breast cancer training (N=12). Breast cancer was induced in mammary fat pad by injection of cancer cells (MC4L2) in mice and endurance training protocol was applied for 7 weeks in the experimental group. Tumor volume and MCT1, MCT4, and CD147 expression were measured by micro digital caliper and western blotting technique respectively. Data were analyzed statistically using Student t and Pearson. Significant decreases was found in weight and CD147 expression of tumor after 7 weeks of endurance training in the exercise group compared to the control group. No significant differences were seen in MCT4 expression and tumor volume between the groups (05 / 0p>0.05). Significant correlation was found between tumor MCT1 and CD147 expression (P < 0.05), while the relationship between MCT4 and CD147 expression in tumors was not statistically significant. Endurance training can reduce lactate metabolism in cancer cells through suppression of lactate transporters expression and provides a useful tool in breast cancer treatment or prevention.