The Inflammatory Role of Myeloperoxidase and Its Increased Level in Patients with Coronary Artery Disease

Myeloperoxidase (MPO) has an essential role in the promotion of ather-osclerosis andcoronary artery disease (CA-D). Therefore, this study explored the plasma level of this enzyme in relation to other traditional cardiovascular risk factors in patients with stable and unstable CAD as compared to control subjects. In this study, 30 patients with stable CAD, 30 patients with unstable CAD and 30 control subjects were selected based on angiography procedure. Plasma MPO was measured using an imm-unoassay method. High sensitivity C-rea-ctive protein (hsCRP) level was dete-rmined by a latex-enhanced immunot-urb-id-imetric method. Plasma lipid and lip-op-rotein profiles (LDL-cholesterol, HDL-cholesterol, total cholesterol and trigly-cerides) were also determined by enzymatic methods. Other cardiovascular risk factors were also assigned through medical history and questionnaire. MPO and hsCRP levels were sig-nificantly higher in unstable CAD patients than stable CAD patients. Also, the amou-nts of these two biomarkers were hig-her in stable CAD patients than control subjects (P < 0.01). In patients, MPO level had a significant relationship with hsCRP and the presence of CAD (P < 0.01). Discussion & Elevated level of MPO was a positive independent predictor for the presence of CAD and its plasma le-vels can differentiate between unstable C-AD patients, stable CAD patients and control subjects and may have a diagnostic value.